Reinforced hydrogel network building by a rapid dual-photo-coupling reaction for 3D printing

Zhou, Renjie; Hua, Yujie; Liu, Yang; Bao, Bingkun; Lin, Qiuning; Zhu, Linyong

doi:10.1039/d2cc05677a

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…The photolysis of photolabile groups (Table ) would result in their elimination following a mechanism of photocleavage (Figure ). As a typical photocleavable moiety, the integration of nitrobenzyl ester or its derivatives onto gelation molecules renders the yielded hydrogels a vulnerability to UV irradiation. , Considering that UV light is weak in tissue penetration and strong in potential damage to organisms, the activation wavelength of O-nitrophenyl esters is often further red-shifted via the substitution reaction of an electron-donating group (EDG) for benzene, as demonstrated by the cleavage of 4,5-dimethoxy O-nitrobenzyl moieties occurring at 350–365 nm instead of 300 nm . A photosensitive hydrogel was made with 2-((4,5-dimethoxy-2-nitrobenzyl)oxy)-N-(2-(methacryloyloxy)ethyl)-N,N-dimethyl-2-oxoethan-1-aminium (CBNA) based on on such strategies .…”

Section: Photoresponsive Mechanism Of Hydrogelmentioning

confidence: 99%

Photoresponsive Hydrogels for Tissue Engineering

Luo,

Xiang,

Jiao

et al. 2024

ACS Biomater. Sci. Eng.

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Hydrophilic and biocompatible hydrogels are widely applied as ideal scaffolds in tissue engineering. The “smart” gelation material can alter its structural, physiochemical, and functional features in answer to various endo/exogenous stimuli to better biomimic the endogenous extracellular matrix for the engineering of cells and tissues. Light irradiation owns a high spatial-temporal resolution, complete biorthogonal reactivity, and fine-tunability and can thus induce physiochemical reactions within the matrix of photoresponsive hydrogels with good precision, efficiency, and safety. Both gel structure (e.g., geometry, porosity, and dimension) and performance (like conductivity and thermogenic or mechanical properties) can hence be programmed on-demand to yield the biochemical and biophysical signals regulating the morphology, growth, motility, and phenotype of engineered cells and tissues. Here we summarize the strategies and mechanisms for encoding light-reactivity into a hydrogel and demonstrate how fantastically such responsive gels change their structure and properties with light irradiation as desired and thus improve their applications in tissue engineering including cargo delivery, dynamic three-dimensional cell culture, and tissue repair and regeneration, aiming to provide a basis for more and better translation of photoresponsive hydrogels in the clinic.

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