Reinfection with <i>Streptococcus suis</i> analysed by whole genome sequencing

Willemse, Niels; Ende, Arie van der; Schultsz, Constance

doi:10.1111/zph.12528

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…S. suis ST16 isolates have never been isolated from human patients but are highly implicated in invasive disease in pigs in The Netherlands [26]. The serotype 2 CPS appears to induce very little to no protective immunity, as was illustrated by a case of reinfection with S. suis serotype 2 in a Dutch slaughterhouse worker [112].…”

Section: Appendix E Proceeding From the 4th International Workhop On Streptococcus Suismentioning

confidence: 99%

Update on Streptococcus suis Research and Prevention in the Era of Antimicrobial Restriction: 4th International Workshop on S. suis

et al. 2020

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Streptococcus suis is a swine pathogen and a zoonotic agent afflicting people in close contact with infected pigs or pork meat. Sporadic cases of human infections have been reported worldwide. In addition, S. suis outbreaks emerged in Asia, making this bacterium a primary health concern in this part of the globe. In pigs, S. suis disease results in decreased performance and increased mortality, which have a significant economic impact on swine production worldwide. Facing the new regulations in preventive use of antimicrobials in livestock and lack of effective vaccines, control of S. suis infections is worrisome. Increasing and sharing of knowledge on this pathogen is of utmost importance. As such, the pathogenesis and epidemiology of the infection, antimicrobial resistance, progress on diagnosis, prevention, and control were among the topics discussed during the 4th International Workshop on Streptococcus suis (held in Montreal, Canada, June 2019). This review gathers together recent findings on this important pathogen from lectures performed by lead researchers from several countries including Australia, Canada, France, Germany, Japan, Spain, Thailand, The Netherlands, UK, and USA. Finally, policies and recommendations for the manufacture, quality control, and use of inactivated autogenous vaccines are addressed to advance this important field in veterinary medicine.

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Section: Appendix E Proceeding From the 4th International Workhop On Streptococcus Suismentioning

confidence: 99%

Update on Streptococcus suis Research and Prevention in the Era of Antimicrobial Restriction: 4th International Workshop on S. suis

et al. 2020

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“…WGS approaches have increasingly been used to investigate S. suis isolates, including molecular determination of serotype [44], characterization of outbreaks [45,46], evaluation of S. suis reinfection [47], and to determine the population structure of S. suis isolates of serotype 2 belonging to ST25 and ST28 [48,49], as well as of serotype 9 [50]. WGS-based bacterial typing strategies commonly use one of two approaches: SNP (sequence)-based, or MLST (allele)-based.…”

Section: Whole-genome Sequencing Approachesmentioning

confidence: 99%

Tools for Molecular Epidemiology of Streptococcus suis

et al. 2020

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Diseases caused by Streptococcus suis are a significant economic and welfare concern in pigs as well as in humans. Several molecular methods have been applied to investigate S. suis strain diversity and identify phylogenetic groups. Multilocus sequence typing (MLST), commonly used to differentiate between S. suis strains, has been instrumental in identifying that the species is genetically highly diverse. Recent advances in whole-genome analysis have resulted in schemes permitting the classification of S. suis populations as pathogenic or non-pathogenic, or disease-associated or non-disease associated. Here, we review these and other molecular approaches that can be used for surveillance, outbreak tracking, preventative health management, effective treatment and control, as well as vaccine development, including PCR based-assays that are easy to apply in modest diagnostic settings and which allow for the rapid screening of a large number of isolates at relatively low cost, granting the identification of several major clonal complexes of the S. suis population.

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“… 45 , 46 Zoonotic SS2CC20 infections have only been described in the Netherlands, where S. suis infection is an occupational hazard for which it appears most likely that S. suis enters the bloodstream after direct infection via skin lesions. 5 , 46 , 47 …”

Section: Discussionmentioning

confidence: 99%

Translocation across a human enteroid monolayer by zoonotic Streptococcus suis correlates with the presence of Gb3-positive cells

Roodsant,

van der Ark,

Schultsz

2024

iScience

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Reinfection with Streptococcus suis analysed by whole genome sequencing

Cited by 4 publications

References 18 publications

Update on Streptococcus suis Research and Prevention in the Era of Antimicrobial Restriction: 4th International Workshop on S. suis

Update on Streptococcus suis Research and Prevention in the Era of Antimicrobial Restriction: 4th International Workshop on S. suis

Tools for Molecular Epidemiology of Streptococcus suis

Translocation across a human enteroid monolayer by zoonotic Streptococcus suis correlates with the presence of Gb3-positive cells

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