Rehospitalization Through Childhood and Adolescence: Association with Neonatal Morbidities in Infants of Very Low Birth Weight

Kuint, Jacob; Lerner‐Geva, Liat; Chodick, Gabriel; Boyko, Valentina; Shalev, Varda; Reichman, Brian; Heymann, Eli; Zangen, Shmuel; Smolkin, Tatyana; Mimouni, Francis; Bader, David A.; Rothschild, Avi; Strauss, Zipora; Felszer, Clari; Jeryes, Jamalia; Tov-Friedman, Smadar Even; Bar‐Oz, Benjamin; Feldman, Michaël; Saad, Nizar; Flidel-Rimon, Orna; Weisbrod, Meir; Lubin, Daniel; Litmanovitz, Ita; Kugelman, Amir; Shinwell, Eric S.; Klinger, G; Nijim, Yousif; Golan, Agneta; Mandel, Dror; Fleisher-Sheffer, Vered; Kohelet, David; Bakhrakh, Lev

doi:10.1016/j.jpeds.2017.05.078

Cited by 36 publications

(31 citation statements)

References 20 publications

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“…The methodology of data collection, definitions and linkage of the VLBW infant database and MHS data files has previously been reported in detail [1]. This study was approved by the institutional review boards of MHS (MHS 20/2014) and of the Sheba Medical Center (Ramat Gan, Israel; SMC 1587-14).…”

Section: Methodsmentioning

confidence: 99%

“…Data were collected by the Israel national VLBW infant (≤1,500 g) database on infants born in Israel from January 1, 1995 through to December 31, 2012, as previously reported [1]. All 28 neonatal departments in Israel comprising the Israel Neonatal Network participated in the data collection (Appendix).…”

Section: Methodsmentioning

confidence: 99%

“…Definitions of the neonatal morbidities used were concordant with those of the Vermont Oxford Neonatal Database Manual of Operation (https://public.vtoxford.org) and have been previously reported in detail [1]. The definitions and severity of necrotizing enterocolitis (NEC) , intraventricular hemorrhage (IVH), cystic periventricular leukomalacia (PVL), BPD, and retinopathy of prematurity (ROP) were reported previously in detail [1].…”

Section: Methodsmentioning

confidence: 99%

“…The ongoing utilization of medical resources, including re-hospitalization, by very low birth weight (VLBW) infants after discharge from their birth hospital has been previously described by our group and by others [1-4]. The type of re-hospitalization needed by children and adolescents born prematurely is less well documented.…”

Section: Introductionmentioning

confidence: 94%

“…The type of re-hospitalization needed by children and adolescents born prematurely is less well documented. It has been reported that major neonatal morbidities, both specifically and in combination, are associated with increasing rates of re-hospitalization over many years [1, 5-11]. Bronchopulmonary dysplasia (BPD) has been shown as a major risk factor for re-hospitalization mainly during infancy [12].…”

Section: Introductionmentioning

confidence: 99%

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Type of Re-Hospitalization and Association with Neonatal Morbidities in Infants of Very Low Birth Weight

et al. 2019

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Background: Preterm infants are at high risk for long-term morbidities and an increased rate of re-hospitalization. Objective: The aim of this study was to evaluate the type of re-hospitalization of very low birth weight (VLBW) infants, from infancy through adolescence, and to assess the association of neonatal morbidities with specific types of re-hospitalization. Study Design: The study cohort comprised 6,385 VLBW infants who were registered with the Maccabi Healthcare Services (MHS) from their birth hospitalization. Data were collected for up to 18 years (median 10.7 years) following neonatal intensive care unit discharge. Hospitalization types were determined from the MHS coding. Neonatal morbidities included necrotizing enterocolitis (NEC), grades 3–4 intraventricular hemorrhage (IVH), periventricular leukomalacia (PVL), bronchopulmonary dysplasia (BPD), and retinopathy of prematurity (ROP). Adjusted hazard ratios (aHR) and 95% confidence intervals (CI) were calculated using the Cox proportional hazards model. Results: Overall, 3,956 infants were re-hospitalized at least once and a total of 11,595 hospitalization types were identified. NEC, IVH, PVL, and BPD were associated with significantly higher aHRs for general pediatric (aHR 1.28–1.55), general surgical (aHR 1.18–1.46), and pediatric intensive care unit (aHR 1.57–2.04) hospitalizations. IVH and PVL were associated with significantly higher aHRs for orthopedic (aHR 2.12 and 4.88, respectively) and ophthalmology (1.76 and 4.02, respectively) hospitalizations. IVH was associated with a 14.2-fold higher aHR for neurosurgical admissions, and ROP with a 1.62-fold higher aHR for ophthalmology hospitalizations. Conclusion: Among VLBW infants, specific patterns of re-hospitalization types associated with major neonatal morbidities were identified as particularly high risks for orthopedic and ophthalmology hospitalizations in infants with IVH and PVL, and for intensive care admissions in infants with NEC and BPD.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Type of Re-Hospitalization and Association with Neonatal Morbidities in Infants of Very Low Birth Weight

et al. 2019

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Respiratory morbidity in very low birth weight infants through childhood and adolescence

Littner

Volinsky

Kuint

et al. 2021

Pediatric Pulmonology

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Objective: To describe the long-term (up to 18 years of age) respiratory outcomes of children and adolescents born at very low birth weight (VLBW; ≤1500 g) in comparison with that of children born >1500 g.Methods: An observational, longitudinal, retrospective study comparing VLBW infants with matched controls, registered at a large health maintenance organization in Israel. Pulmonary outcomes collected anonymously from the electronic medical files included respiratory illness diagnoses, purchased medications for respiratory problems, office visits with either a pediatric pulmonologist or cardiologist and composite respiratory morbidity combining all these parameters.Results: Our study included 5793 VLBW infants and 11,590 matched controls born between 1998 and 2012. The majority (99%) of VLBW infants were premature (born < 37 weeks' gestation), while 93% of controls were born at term. The composite respiratory morbidity was significantly higher in VLBW infants compared with controls in all age groups (relative risk [95% confidence interval]: 1 year: 1.22

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Bronchopulmonary dysplasia in adults: Exploring pathogenesis and phenotype

Wozniak,

Makhoul,

Botros

2023

Pediatric Pulmonology

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This review highlights both the longstanding impact of bronchopulmonary dysplasia (BPD) on the health of adult survivors of prematurity and the pressing need for prospective, longitudinal studies of this population. Conservatively, there are an estimated 1,000,000 survivors of BPD in the United States alone. Unfortunately, most of the available literature regarding outcomes of lung disease due to prematurity naturally focuses on pediatric patients in early or middle childhood, and the relative amount of literature on adult survivors is scant. As the number of adult survivors of BPD continues to increase, it is essential that both adult and pediatric pulmonologists have a comprehensive understanding of the pathophysiology and underlying disease process, including the molecular signaling pathways and pro‐inflammatory modulators that contribute to the pathogenesis of BPD. We summarize the most common presenting symptoms for adults with BPD and identify the critical challenges adult pulmonologists face in managing the care of survivors of prematurity. Specifically, these challenges include the wide variability of the clinical presentation of adult patients, comorbid cardiopulmonary complications, and the paucity of longitudinal data available on these patients. Adult survivors of BPD have even required lung transplantation, indicating the high burden of morbidity that can result from premature birth and subsequent lung injury. In addition, we analyze the disparate symptoms and management approach to adults with “old” BPD versus “new” BPD. The aim of this review is to assist pulmonologists in understanding the underlying pathophysiology of BPD and to improve clinical recognition of this increasingly common pulmonary disease.

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Rehospitalization Through Childhood and Adolescence: Association with Neonatal Morbidities in Infants of Very Low Birth Weight

Cited by 36 publications

References 20 publications

Type of Re-Hospitalization and Association with Neonatal Morbidities in Infants of Very Low Birth Weight

Type of Re-Hospitalization and Association with Neonatal Morbidities in Infants of Very Low Birth Weight

Respiratory morbidity in very low birth weight infants through childhood and adolescence

Bronchopulmonary dysplasia in adults: Exploring pathogenesis and phenotype

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