Rehabilitation of specific conditions

Olver, John; Williams, Gavin; Adair, Brooke; Morris, Meg E.

doi:10.1017/cbo9781139012942.013

Cited by 2 publications

(3 citation statements)

References 447 publications

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“…The results of decades of clinical research 57,58 indicate that the best way to ensure optimal outcomes is to provide clear information about what to do during the recovery process and also to negotiate clear therapeutic goals. It is arguably advantageous, following the grafting of neurons in people with PD, to systematically enhance motivation, goal-directed activities, physical activity levels, and the reinforcement of improvements in functioning if and when they emerge.…”

Section: Theory and Methodsmentioning

confidence: 99%

“…54 We propose that one of the important causes for the diminished efficacy is the reduced opportunity for the participants in double-blind RCTs to learn how to make use of the newly grafted DA-rich cells for achieving optimal recovery. 13,54 The results of decades of clinical research 57,58 indicate that the best way to ensure optimal outcomes is to provide clear information about what to do during the recovery process and also to negotiate clear therapeutic goals. It is arguably advantageous, following the grafting of neurons in people with PD, to systematically enhance motivation, goal-directed activities, physical activity levels, and the reinforcement of improvements in functioning if and when they emerge.…”

Section: Theory and Methodsmentioning

confidence: 99%

See 1 more Smart Citation

A Critical Evaluation of the Methodological Obstacles to Translating Cell-Based Research Into an Effective Treatment for People With Parkinson’s Disease

Polgar

Karimi

Buultjens

et al. 2016

Neurorehabil Neural Repair

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The remarkable scientific and technological advances in the field of cell research have not been translated into viable restorative therapies for brain disorders. In this article, we examine the best available evidence for the clinical efficacy of reconstructive intracerebral transplantation in people with Parkinson's disease (PD), with the aim of identifying methodological obstacles to the translation process. The major stumbling block is the fact that the potential contributions of people with neural grafts and the effects of the physical and social environment in which they recover have not been adequately investigated and applied to advancing the clinical stages of the research program. We suggest that the biopsychosocial model along with emerging evidence of targeted rehabilitation can provide a useful framework for conducting research and evaluation that will ensure the best possible outcomes following intracerebral transplantation for PD.

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Section: Theory and Methodsmentioning

confidence: 99%

Section: Theory and Methodsmentioning

confidence: 99%

A Critical Evaluation of the Methodological Obstacles to Translating Cell-Based Research Into an Effective Treatment for People With Parkinson’s Disease

Polgar

Karimi

Buultjens

et al. 2016

Neurorehabil Neural Repair

View full text Add to dashboard Cite

show abstract

“…Functional connectivity following brain damage, brain surgery or stem cell therapy could be promoted through goal directed practice, gait retraining, hand rehabilitation and progressive resistance strength training and other "exercises" and by structuring the environment and the tasks they perform. According to Olver et al [2013] [54] adaptive learning could possibly be enhanced through … "participation in rehabilitation programs that promote positive neural changes through the processes of learning and practice. Research exploring adaptive, goal directed motor learning strategies for advancing neural grafting and stem cell therapy which have not to date adequately embraced rehabilitation as an adjunct to care and to optimize therapy outcomes".…”

Section: Implementation Of the Treatmentsmentioning

confidence: 99%