Rehabilitation of Organophosphate Induced Delayed Polyneuropathy

Sahoo, Pabitra Kumar; Mohamed, Faiz; Sahu, Mamata Manjari; Ganesh, Shankar

doi:10.4172/2329-9096.1000481

Cited by 2 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with intermediate syndrome or organophosphate-induced delayed polyneuropathy should be addressed symptomatically because there is presently no cure for either condition 14 . According to a long-term follow-up study, rehabilitation therapy combined with appropriate nursing care has been demonstrated to improve the disease 15 .…”

Section: Clinical Discussionmentioning

confidence: 99%

Wallerian degeneration in the brain after organophosphorus poisoning: a case report

Gajurel¹,

Giri

Poudel

et al. 2023

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

Introduction and Importance: The type, quantity, and potency of the organophosphorus compound (OPC) taken determine the symptoms of OPC poisoning as well as their severity. The exact etiology for organophosphorus (OP) poisoning delay neuropathy regulating Wallerian degeneration is still unknown. Case Presentation: We report here a rare case of a 25-year-old lady with Wallerian degeneration in the brain found in an MRI in a patient after OPC ingestion. MRI of the brain, in our case, shows Wallerian degeneration of the corona radiata, internal capsule, and midbrain. Clinical Discussion: Some OPCs can lead to OP-induced delayed neuropathy, a form of delayed neurotoxicity in humans (OPIDN). The distal axonopathy’s (in OPIDN) morphological pattern resembles Wallerian degeneration, which happens in vitro following nerve damage. Although delayed Wallerian degeneration from organophosphate poisoning often affects the peripheral nervous system, it can also affect the central nervous system. Rehabilitation therapy combined with appropriate nursing care has been demonstrated to improve the disease. Conclusion: Central nervous system involvement after OP poisoning is rare, and MRI of the brain and spinal cord can document evidence of Wallerian degeneration after OP poisoning.

show abstract

Section: Clinical Discussionmentioning

confidence: 99%

Wallerian degeneration in the brain after organophosphorus poisoning: a case report

Gajurel¹,

Giri

Poudel

et al. 2023

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

show abstract

“…3 Rehabilitative therapy along with proper nursing care has shown to improve the condition from a long-term follow-up study. 19 Corticosteroids have also been used as a neuroprotective drug in OPIDN. 20 In our case, the patient was treated with intravenous methylprednisolone and extensive physiotherapy of the lower limbs.…”

Section: Discussionmentioning

confidence: 99%

Delayed myelopathy after organophosphate intoxication: A case report

Gautam

Sapkota

Ojha

et al. 2022

SAGE Open Medical Case Reports

View full text Add to dashboard Cite

Organophosphate-induced delayed neuropathy, a central-distal axonopathy, passes through latent, progressive, static and improvement phases. During the improvement phase, the peripheral nerves regenerate unmasking the spinal cord lesion with myelopathic features. We report a case of a 16-year-old male who developed myelopathy 6 weeks following chlorpyrifos poisoning. He had a motor weakness of 4/5 in bilateral hips and 3/5 in bilateral knees and ankles. Spasticity and exaggerated reflexes with ankle clonus were present in the lower limbs. Sensory and the upper limb motor examinations were all normal. Pertinent blood, cerebrospinal fluid and nerve conduction tests were normal. Magnetic resonance imaging of the spine showed features of cord atrophy. Three months following physiotherapy, his power improved to 5/5 in bilateral knee and hip joints and 4/5 in bilateral ankles with spasticity. Organophosphate-induced delayed neuropathy can present as earlier as 6 weeks with myelopathy. Previous history of organophosphorous exposure is important in myelopathy or peripheral neuropathy.

show abstract

Rehabilitation of Organophosphate Induced Delayed Polyneuropathy

Cited by 2 publications

References 2 publications

Wallerian degeneration in the brain after organophosphorus poisoning: a case report

Wallerian degeneration in the brain after organophosphorus poisoning: a case report

Delayed myelopathy after organophosphate intoxication: A case report

Contact Info

Product

Resources

About