Rehabilitation of executive dysfunction following brain injury: “Content-free” cueing improves everyday prospective memory performance

Fish, Jessica; Evans, Jonathan J.; Nimmo, Morag; Martín, Emma; Kersel, Denyse A.; Bateman, Andrew; Wilson, Barbara A.; Manly, Tom

doi:10.1016/j.neuropsychologia.2006.09.015

Cited by 156 publications

(117 citation statements)

References 43 publications

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“…Such patients have been thought to have a difficulty in bringing to mind delayed intentions at the appropriate time, rather than forming a representation of them (Burgess et al, 2000;Uretzky and Gilboa, 2010). In addition, some patients derive considerable benefit from nonspecific cues (e.g., an auditory beep) that remind them of the existence of a delayed intention but not its content (Fish et al, 2007). This would be expected if PM failures in such patients do result not from an inability to store the content of future intentions, but rather from an inability to activate the representations of such intentions in posterior brain regions.…”

Section: Discussionmentioning

confidence: 99%

Decoding the Content of Delayed Intentions

Gilbert¹

2011

J. Neurosci.

130

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Rostrolateral prefrontal cortex (RLPFC) plays a key role in our ability to postpone the execution of intended behaviors until after another activity has been performed. However, it is poorly understood in computational terms. One crucial question is whether RLPFC represents the content of delayed intentions or plays a nonspecific role. In this human functional magnetic resonance imaging study (n ϭ 32), RLPFC was active while participantsstoreddelayedintentionsduringadistractingongoingtask.Multivariateanalysisshowedthattheintendedcueforfutureactionand the intended behavior could be decoded from distinct posterior brain regions. However, the content of intentions could not be decoded from RLPFC itself. Functional connectivity analysis showed that RLPFC increased its coupling with content-representing regions during intention storage. Furthermore, trials with relatively high RLPFC activity were associated with enhanced decoding. Thus, RLPFC may enable realization of delayed intentions via interactions with posterior brain regions, which represent their content.

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Section: Discussionmentioning

confidence: 99%

Decoding the Content of Delayed Intentions

Gilbert¹

2011

J. Neurosci.

130

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“…Emerging evidence within the TBI literature suggests that both meta-cognitive approaches, through which individuals are trained to respond to a non-specific external cue by selfmonitoring for future goals (Fish et al, 2007), and restorative approaches, whereby PM tasks are administered repetitively with progressively increasing time intervals , offer some promise in this area. However, alcohol dependents may display more subtle PM impairments than those with TBI, and thus benefit from less resource-intensive approaches.…”

Section: Discussionmentioning

confidence: 99%

Prospective memory and future event simulation in individuals with alcohol dependence

Griffiths¹,

Hill

Morgan³

et al. 2012

Addiction

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1 OVERVIEWThis major research project focuses on the possible influence that chronic substance use may have on prospective memory (PM) ability.Part one consists of a literature review examining the associations between recreational substance use and impairments in PM. This identifies 24 studies from 23 publications examining PM ability in recreational substance users. Although PM impairments are reported by most, the review highlights a number of methodological weaknesses in the existing body of research. These include an over-reliance on self report PM measures, the use of inadequate objective assessments, and limitations in internal and external validity. Suggestions are made for how methodological limitations may be overcome in future work.Part two is an empirical paper which describes a study that aimed to overcome the limitations highlighted in part one. This compared the performance of an alcohol dependent group to that of an age and premorbid ability matched control group, on an objective PM measure called the Virtual Week. It was found that the event based PM performance of alcohol dependents was strongly associated with indices of both alcohol usage and severity of alcohol dependence, and significantly impaired compared to that of controls. Furthermore, an imagining technique improved controls' time based PM, but did not improve alcohol dependents' PM.These findings are discussed in terms of the relevance of strategy application to successful PM functioning, and the implications this may hold for clinical practice.Part three consists of a critical appraisal of the research process, which explains why various methodological choices were made and how particular challenges were overcome as they arose. Certain conceptual issues are also reflected upon and their relevance to future research discussed.2

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“…In fact, many subjects described memory problems, which could be characterized as prospective memory problems; remembering what to do in the future rather than remembering the past. Prospective memory is considered to have a distinct executive component (Fish et al, 2007), which would agree with the differences between controls and MCI-norm on the executive tests. Another explanation could be that many subjects think of language (naming) problems as trouble remembering words (i.e., memory problems).…”

Section: Neuropsychology Of MCI With Alzheimer-typical Csf 587mentioning

confidence: 99%

Episodic memory and speed/attention deficits are associated with Alzheimer-typical CSF abnormalities in MCI

Nordlund

Rolstad

Klang

et al. 2008

J Int Neuropsychol Soc

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Mild cognitive impairment (MCI) is regarded as the prodromal stage of dementia disorders, such as Alzheimer's disease (AD).Objective: To compare the neuropsychological profiles of MCI subjects with normal concentrations of total tau (T-t) and Ab42 in CSF (MCI-norm) to MCI subjects with deviating concentrations of the biomarkers (MCI-dev). MCI-norm (N 5 73) and MCI-dev (N 5 73) subjects were compared to normal controls (N 5 50) on tests of speed0attention, memory, visuospatial function, language and executive function.Results: MCI-norm performed overall better than MCI-dev, specifically on tests of speed and attention and episodic memory. When MCI-dev subjects were subclassified into those with only high T-tau (MCI-tau), only low Ab42 (MCI-Ab) and both high T-tau and low Ab42 (MCI-tauAb), MCI-tauAb tended to perform slightly worse. MCI-tau and MCI-Ab performed quite similarly.Conclusions: Considering the neuropsychological differences, many MCI-norm probably had more benign forms of MCI, or early non-AD forms of neurodegenerative disorders. Although most MCI-dev performed clearly worse than MCI-norm on the neuropsychological battery, some did not show any deficits when compared to age norms. A combination of CSF analyses and neuropsychology could be a step toward a more exact diagnosis of MCI as prodromal AD. (JINS, 2008, 14, 582-590.)

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Rehabilitation of executive dysfunction following brain injury: “Content-free” cueing improves everyday prospective memory performance

Cited by 156 publications

References 43 publications

Decoding the Content of Delayed Intentions

Decoding the Content of Delayed Intentions

Prospective memory and future event simulation in individuals with alcohol dependence

Episodic memory and speed/attention deficits are associated with Alzheimer-typical CSF abnormalities in MCI

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