Rehabilitation of burn injuries

Young, Alan

doi:10.1016/s1047-9651(03)00073-1

Cited by 17 publications

(11 citation statements)

References 21 publications

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“…Using a soldering iron with a set temperature we managed to create deep second-degree burns in human skin explants. Deep second-degree burn wounds are characterized by damage of the epidermis and large areas of the dermis, but underlying fat tissue, nerves, and muscles are not affected 32 . Throughout this study in total 39 skin tissue samples from six different donors were burned at 300 °C for 15 s by multiple operators.…”

Section: Discussionmentioning

confidence: 99%

Active neutrophil responses counteract Candida albicans burn wound infection of ex vivo human skin explants

Müller

Bulman

Wagner

et al. 2020

Sci Rep

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Burn wounds are highly susceptible sites for colonization and infection by bacteria and fungi. Large wound surface, impaired local immunity, and broad-spectrum antibiotic therapy support growth of opportunistic fungi such as Candida albicans, which may lead to invasive candidiasis. Currently, it remains unknown whether depressed host defenses or fungal virulence drive the progression of burn wound candidiasis. Here we established an ex vivo burn wound model, where wounds were inflicted by applying preheated soldering iron to human skin explants, resulting in highly reproducible deep second-degree burn wounds. Eschar removal by debridement allowed for deeper C. albicans penetration into the burned tissue associated with prominent filamentation. Active migration of resident tissue neutrophils towards the damaged tissue and release of pro-inflammatory cytokine IL-1β accompanied the burn. The neutrophil recruitment was further increased upon supplementation of the model with fresh immune cells. Wound area and depth decreased over time, indicating healing of the damaged tissue. Importantly, prominent neutrophil presence at the infected site correlated to the limited penetration of C. albicans into the burned tissue. Altogether, we established a reproducible burn wound model of candidiasis using ex vivo human skin explants, where immune responses actively control the progression of infection and promote tissue healing.

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Section: Discussionmentioning

confidence: 99%

Active neutrophil responses counteract Candida albicans burn wound infection of ex vivo human skin explants

Müller

Bulman

Wagner

et al. 2020

Sci Rep

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“…Rehabilitation minimizes the adverse consequences of the burn by improving functional ability, enhancing psychological well-being, facilitating early return to work/school and improving quality of life [ 5 ]. As rehabilitation occurs, the burn patient is able to attain a degree of pre-injury abilities as closely as possible [ 6 , 7 ] and is able to do things that are desirable to them as recover progresses [ 8 , 9 ].…”

Section: Background and Rationalementioning

confidence: 99%

Effects of a nurse-led transitional burns rehabilitation programme (4Cs-TBuRP) for adult burn survivors: protocol for a randomised controlled trial

Bayuo

Wong

Chung

2021

Trials

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Background Transitioning from the burn unit to the home/community can be chaotic with limited professional support. Some adult burn survivors may face varied concerns leading to poor outcomes in the early post-discharge period with limited access to professional help. Based on these, a nurse-led transitional burns rehabilitation programme has been developed and the current trial aims to ascertain its effects as well as explore the implementation process. Methods A single-centre, double-arm randomised controlled trial with a process evaluation phase will be utilised for this study. All adult burn survivors aged ≥ 18 years with burn size ≥ 10% total burn surface area at the site during the study period will be screened for eligibility at least 72 h to discharge. A sample size of 150 will be block randomised to treatment (receiving the nurse-led transitional care programme and routine post-discharge service) and control groups (receiving routine post-discharge service). The nurse-led transitional care programme comprises of predischarge and follow-up phases with the delivery of bundle of holistic interventions lasting for 8 weeks. There are three timelines for data collection: baseline, immediate post intervention, and 4 weeks post-intervention. Discussion The findings from this study can potentially inform the development and organisation of post-discharge care and affirm the need for ongoing comprehensive home-based care for burn survivors and their families Trial registration ClinicalTrials.govNCT04517721. Registered on 20 August 2020

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“…After burn injury, the normal protective mechanism of the skin is severely compromised (Young 2002, Bousfield 2003, Herndon 2007). Without immediate medical intervention, the prognosis for extensive burns is poor, with patients experiencing hypovolaemic shock, sepsis, multiorgan failure and consequent high mortality rates (Young 2002, Bousfield 2003, Herndon 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Over the past 50 years, mortality rates following major burns have dramatically decreased because of expanding knowledge of the pathophysiology of thermal injury and its systemic consequences, medical technology advances and improved surgical techniques (Young 2002, Bousfield 2003, Herndon 2007). Half a century ago, approximately 50% of victims survived if their burns involved more than 40% total body surface area (TBSA) (Bull & Fisher 1949).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Psychological adjustments made by postburn injury patients: an integrative literature review

Klinge

Chamberlain

Redden

et al. 2009

Journal of Advanced Nursing

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Rehabilitation of burn injuries

Cited by 17 publications

References 21 publications

Active neutrophil responses counteract Candida albicans burn wound infection of ex vivo human skin explants

Active neutrophil responses counteract Candida albicans burn wound infection of ex vivo human skin explants

Effects of a nurse-led transitional burns rehabilitation programme (4Cs-TBuRP) for adult burn survivors: protocol for a randomised controlled trial

Psychological adjustments made by postburn injury patients: an integrative literature review

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