Rehabilitation in multiple sclerosis

Béthoux, François; Sutliff, Matthew

doi:10.1017/cbo9781139023986.065

Cited by 3 publications

(3 citation statements)

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“…33 Furthermore, motor fatigue, which is characterized by failure to sustain the force of muscle contractions, is also hypothesized to contribute to a decreased result on repetitive or longer lasting tasks such as the 6MWT/2MWT. 34 The 6MWT has been demonstrated to be reliable and valid, 22,35 and also sensitive to change as a result of rehabilitation interventions targeting walking ability in chronic stroke and MS. 36,37 Its minimally important change (MIC) for deterioration from the clinician's perspective (which reflects the smallest difference in outcome that signifies an important rather than trivial difference in the clinician's rating) amounts to -55 metres; 38 when extrapolated to the present study, this equals a decrease of 582 strides on a daily basis in the total sample (obtained by MIC*-value). The 6MWT is considered to be a feasible clinical test as only one test execution is required since no practice effects were found in stroke patients and pwMS.…”

Section: Discussionmentioning

confidence: 99%

Predicting habitual walking performance in multiple sclerosis: relevance of capacity and self-report measures

et al. 2010

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The objective was to establish the extent to which physical functioning capacity and self-report measures are able to predict the habitual walking performance in ambulatory persons with multiple sclerosis. Fifty persons with multiple sclerosis (Expanded Disability Status Scale, EDSS, 1.5-6.5) were tested on leg muscle strength as well as walking and balance capacity, and completed self-report indices on perceived physical functioning. Habitual walking performance, that is, the real amount of steps that is performed in the customary living environment, was registered by means of an ambulant accelerometer-based monitor during seven consecutive days. Mild (EDSS 1.5-4.0, n = 29) and moderate (EDSS 4.5-6.5, n = 21) multiple sclerosis subgroups were additionally distinguished as predictor variables and values were hypothesized to differ depending on multiple sclerosis severity and concomitant ambulatory function. Multiple regression analyses yielded a single most significant predictor for each (sub)group with other variables making no independent contribution to the variation in habitual walking performance. For the total study sample, this was the 6-Minute Walking Test (R(2) = 0.458, p < 0.01). In the mild multiple sclerosis subgroup, the 6-Minute Walking Test was again most predictive, yet to a modest degree (R(2) = 0. 187, p = 0.02). In the moderate multiple sclerosis subgroup, the 2-Minute Walking Test explained over half of the variance (R(2) = 0.532, p < 0.01). Habitual walking performance is best reflected by longer walking capacity tests. The extent to which it can be predicted based on clinical testing is larger in a multiple sclerosis patient sample with more severe walking disability. Ambulatory monitoring, however, includes aspects of community ambulation not captured in the clinic, and must be considered as an additional outcome for evaluating interventions in multiple sclerosis.

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Section: Discussionmentioning

confidence: 99%

Predicting habitual walking performance in multiple sclerosis: relevance of capacity and self-report measures

et al. 2010

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“…Depression was measured by Patient Health Questionnaire‐9 (PHQ‐9) . Fatigue severity was assessed with Modified Fatigue Impact Scale (MFIS) .…”

Section: Methodsmentioning

confidence: 99%

Fatigue and depression predict quality of life in patients with early multiple sclerosis: a longitudinal study

Nourbakhsh

Julián

Waubant

2016

Euro J of Neurology

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“…The prevalence of fatigue in MS ranges from 70% to 90%. 6 A large survey revealed that almost all patients report to be most fatigued in the afternoon or evening. 7 This diurnal increase of self-reported fatigue has been confirmed in clinical trials.…”

Section: Introductionmentioning

confidence: 99%

Effect of time of day on walking capacity and self-reported fatigue in persons with multiple sclerosis: a multi-center trial

et al. 2011

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Rehabilitation in multiple sclerosis

Cited by 3 publications

References 54 publications

Predicting habitual walking performance in multiple sclerosis: relevance of capacity and self-report measures

Predicting habitual walking performance in multiple sclerosis: relevance of capacity and self-report measures

Fatigue and depression predict quality of life in patients with early multiple sclerosis: a longitudinal study

Effect of time of day on walking capacity and self-reported fatigue in persons with multiple sclerosis: a multi-center trial

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