Rehabilitation, exercise, and related non-pharmacological interventions for chemotherapy-induced peripheral neurotoxicity: Systematic review and evidence-based recommendations

Tamburin, Stefano; Park, Susanna B.; Schenone, Angelo; Mantovani, Elisa; Hamedani, Mehrnaz; Alberti, Paola; Kabak, Vesile Yıldız; Kleckner, Ian R.; Kolb, Noah; Mazzucchelli, Miryam; McNeish, Brendan; Cavaletti, Guido; Höke, Ahmet

doi:10.1016/j.critrevonc.2021.103575

Cited by 24 publications

(30 citation statements)

References 66 publications

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“…Many non-pharmacological agents and interventions have been tested, and only physical exercise (particularly endurance training) has demonstrated modest benefit in preventing CIPN based on moderate evidence. 7 , 8 Sensorimotor (balance) training may be explored for the prevention and management of CIPN based on its safety and moderate-level evidence of its efficacy in improving CIPN symptoms and balance. 8 Regular screening for patient physical activity can be operationalized with tools such as the Physical Activity Vital Sign.…”

Section: What Do the Data Tell Us About Cipn Management?mentioning

confidence: 99%

“… 7 , 8 Sensorimotor (balance) training may be explored for the prevention and management of CIPN based on its safety and moderate-level evidence of its efficacy in improving CIPN symptoms and balance. 8 Regular screening for patient physical activity can be operationalized with tools such as the Physical Activity Vital Sign. 9 Further, assessing for functional and balance disturbances can inform whether an individual requires referral to a physical therapist or clinical exercise physiologist.…”

Section: What Do the Data Tell Us About Cipn Management?mentioning

confidence: 99%

“…Despite the lack of evidence, cryotherapy is increasingly observed in the infusion setting; thus, clinicians must be alert and ensure that cryotherapy is only used for patients receiving paclitaxel or docetaxel, as use of cryotherapy during platinum-based chemotherapy (eg., oxaliplatin) could cause further harm. 8 Several other non-pharmacological interventions not supported for the prevention or treatment of CIPN include neurofeedback, electrical stimulation, massage therapy. 8 Non-pharmacological interventions that are currently under study for the prevention or treatment of CIPN, but require further evidence to demonstrate efficacy, include yoga, acupuncture, and transcutaneous electrical nerve stimulation.…”

Section: What Do the Data Tell Us About Cipn Management?mentioning

confidence: 99%

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What do the data say about chemotherapy-induced peripheral neuropathy assessment and management?

Kanzawa-Lee¹,

Knoerl²

2023

Asia-Pacific Journal of Oncology Nursing

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Section: What Do the Data Tell Us About Cipn Management?mentioning

confidence: 99%

Section: What Do the Data Tell Us About Cipn Management?mentioning

confidence: 99%

Section: What Do the Data Tell Us About Cipn Management?mentioning

confidence: 99%

See 1 more Smart Citation

What do the data say about chemotherapy-induced peripheral neuropathy assessment and management?

Kanzawa-Lee¹,

Knoerl²

2023

Asia-Pacific Journal of Oncology Nursing

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“…According to recently published guidelines, there is only a modest recommendation for the treatment of painful CIPN with duloxetine 12 . Rehabilitation, exercise, physical therapy, and other non‐pharmacological approaches have been tested for CIPN, but studies are generally of low quality and data should be cautiously considered 13‐15 . The only strategy to reduce CIPN symptoms is lowering the planned dose of chemotherapy or even discontinuation, which should consider cancer and patient factors and may have a negative effect on survival 7 …”

Section: Introductionmentioning

confidence: 99%

“…12 Rehabilitation, exercise, physical therapy, and other non-pharmacological approaches have been tested for CIPN, but studies are generally of low quality and data should be cautiously considered. [13][14][15] The only strategy to reduce CIPN symptoms is lowering the planned dose of chemotherapy or even discontinuation, which should consider cancer and patient factors and may have a negative effect on survival. 7 Delays in CIPN detection, leading to more severe neurotoxicity, increase the risk of irreversible effects that negatively influence long-term QoL and health outcomes.…”

mentioning

confidence: 99%

Wearables, sensors, and smart devices for the detection and monitoring of chemotherapy‐induced peripheral neurotoxicity: Systematic review and directions for future research

Mantovani

Demrozi

Hertz

et al. 2022

J Peripheral Nervous Sys

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Chemotherapy-induced peripheral neurotoxicity (CIPN) diagnosis is largely based on patient reported outcomes. Wearables, sensors, and smart devices may potentially provide early detection and monitoring of CIPN. We systematically reviewed data on wearables, sensors, and smart devices to detect and/or monitor signs and symptoms of CIPN. Moreover, we provide directions and recommendations for future studies.A literature search using PubMed/MEDLINE, Web of Science, IEEE Xplore, and CINHAL databases was conducted from database inception until March 2021.The search was further updated in July 2022 to ensure currency of results. A total of 1885 records were title-abstract screened, 33 full texts were assessed, and 16 were included. The retrieved papers were heterogeneous in terms of study design, sample size, CIPN severity, chemotherapy agents, type of wearable/sensor/device applied, parameters of interest, and purpose. Data are promising and provide preliminary evidence on wearables, sensors, and smart devices for CIPN detection and monitoring.There are several issues and knowledge gaps that should be addressed. We propose a framework for future studies.

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Updated systematic review of the effects of exercise on understudied health outcomes in cancer survivors

Sturgeon,

Kok,

Kleckner

et al. 2023

Cancer Medicine

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IntroductionThe American College of Sports Medicine provided guidelines for exercise prescriptions in cancer survivors for specific cancer‐ and treatment‐related health outcomes. However, there was insufficient evidence to generate exercise prescriptions for 10 health outcomes of cancer treatment. We sought to update the state of evidence.MethodsWe conducted a systematic review of these 10 understudied health outcomes (bone health, sleep, cardiovascular function, chemotherapy‐induced peripheral neuropathy (CIPN), cognitive function, falls and balance, nausea, pain, sexual function, and treatment tolerance) and provided an update of evidence.ResultsWhile the evidence base for each outcome has increased, there remains insufficient evidence to generate exercise prescriptions. Common limitations observed across outcomes included: variability in type and quality of outcome measurement tools, variability in definitions of the health outcomes, a lack of phase III trials, and a majority of trials investigating breast or prostate cancer survivors only.ConclusionWe identified progress in the field of exercise oncology for several understudied cancer‐ and treatment‐related health outcomes. However, we were not able to generate exercise prescriptions due to continued insufficient evidence base. More work is needed to prescribe exercise as medicine for these understudied health outcomes, and our review highlights several strategies to aid in research acceleration within these areas of exercise oncology.

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Rehabilitation, exercise, and related non-pharmacological interventions for chemotherapy-induced peripheral neurotoxicity: Systematic review and evidence-based recommendations

Cited by 24 publications

References 66 publications

What do the data say about chemotherapy-induced peripheral neuropathy assessment and management?

What do the data say about chemotherapy-induced peripheral neuropathy assessment and management?

Wearables, sensors, and smart devices for the detection and monitoring of chemotherapy‐induced peripheral neurotoxicity: Systematic review and directions for future research

Updated systematic review of the effects of exercise on understudied health outcomes in cancer survivors

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