Rehabilitation approach in robot assisted total knee arthroplasty: an observational study

Abstract

Background The purpose of this study is to evaluate the impact of total knee arthroplasty (TKA) with the aid of Navio Robot, comparing it with standard prosthetic surgery on the functional outcomes of patients after an intensive rehabilitation program. Method A case–control observational study was conducted on patients undergoing TKA for severe KOA. All patients underwent the same intensive hospital rehabilitation program of 14 daily sessions lasting 3 h. The following rating scales were administered: Numeric Rating Scale (NRS), Knee Society Score (KSS) and 12-Item Short Form Survey scale. Patient assessments were performed 1 week post-surgery (T0), 1 month post-surgery (T2), and 3 months post-surgery (T3). The primary outcomes were active knee extension and flexion and pain severity. The secondary outcomes were functional capacity and quality of life. Results Using repeated measures ANOVA, we observed at T1 a statistically different difference for the treatment group compared to the control group about KSS (p < 0.05), pain (p < 0.05), and knee flexion (p < 0.05). No statistically significant difference between the two groups was observed for knee extension (p = 0.09) and the SF-12 scale (p = 0.52). At T2 instead, we observed a statistically significant difference for the treatment group compared to the control group as regards KSS (p < 0.05) and knee flexion (p < 0.05), while no statistically significant difference was observed for pain (p = 0.83), knee extension (p = 0.60), and the SF-12 scale (0.44). Conclusions Our study has demonstrated that robot-NAVIO assisted knee prosthesis surgery, associated with a specific intensive rehabilitation treatment, in the short and medium term, determines good pain control, better flexion recovery and a improvement of functional capacity.

The causal relationship between human brain morphometry and knee osteoarthritis: a two-sample Mendelian randomization study

“…The outcome data set was sourced from a genome-wide association study for KOA (ebi-a-GCST007090, 77,052 cases and 378,169 controls from UK Biobank). This study adhered to the following criteria for instrumental variable (IV) selection ( Wu et al, 2022 ), Each SNP was required to exhibit a significant correlation with 83 cortical and subcortical gray‐matter volumes, surpassing the genome-wide significance threshold (P < 5E-8) ( Scaturro et al, 2023 ). Evaluation of linkage disequilibrium (LD) among SNPs was conducted utilizing European sample data sourced from the 1,000 Genomes Project reference panel, wherein only the most statistically significant SNPs were retained, excluding those exhibiting an R2 value <0.001 within a clumping window of 10,000 kb ( Guo et al, 2022 ).…”

“…Knee Osteoarthritis (KOA) is a chronic degenerative disease that predominantly affects the articular cartilage of the knee joint, leading to significant pain, disability, and diminished quality of life among affected individuals ( Wu et al, 2022 ; Scaturro et al, 2023 ). As one of the most common forms of arthritis, KOA imposes a substantial burden on individuals and healthcare systems worldwide ( Guo et al, 2022 ).…”