Aerosol therapy is a form of drug administration that favors a rapid and easy absorption of the same in the respiratory tract; thus favoring great advantages in improving the health status of patients who are subjected to mechanical ventilation in the ICU. The most commonly used drugs are beta-agonist and anticholinergic bronchodilators. The use of this therapy should be used more frequently in these patients, but factors specific to the individual and the drug should be considered for its application; its use in patients with covid-19 should also be considered.