2022
DOI: 10.1097/tp.0000000000004342
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Regulatory T Cells: Liquid and Living Precision Medicine for the Future of VCA

Abstract: Transplant rejection remains a challenge especially in the field of vascularized composite allotransplantation (VCA). To blunt the alloreactive immune response‚ stable levels of maintenance immunosupression are required. However‚ the need for lifelong immunosuppression poses the risk of severe side effects, such as increased risk of infection, metabolic complications, and malignancies. To balance therapeutic efficacy and medication side effects, immunotolerance promoting immune cells (especially regulatory T c… Show more

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Cited by 6 publications
(4 citation statements)
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“…: CAR-Tregs) might be a promising supplementary treatment of rejection in the future. CAR-T cells are typically designed to recognize donor MHC molecules, thus localizing to donor tissues and exerting their regulatory effects in a precise and targeted manner (21). Pharmaceutical therapy regimens are the current gold standard in VCA and are mostly modifications of regimens that have already been established in SOT (23).…”
Section: Tolerance Induction In Vcamentioning
confidence: 99%
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“…: CAR-Tregs) might be a promising supplementary treatment of rejection in the future. CAR-T cells are typically designed to recognize donor MHC molecules, thus localizing to donor tissues and exerting their regulatory effects in a precise and targeted manner (21). Pharmaceutical therapy regimens are the current gold standard in VCA and are mostly modifications of regimens that have already been established in SOT (23).…”
Section: Tolerance Induction In Vcamentioning
confidence: 99%
“…Tregs exert their immunosuppressive effects via cell-to-cell interaction with target immune cells, via removal of IL-2 (potent factor in T cell survival and growth), via anti-inflammatory molecules (TGF-beta) or through costimulatory pathways such as binding to cytotoxic T-lymphocyte-associated protein 4. Nevertheless, irregularity in Tregs can lead to autoimmune disorders, reduced disease tolerance or higher risk for cancer( 21 ). Recent studies have investigated the potential therapeutic value of genetically modified patient-derived Tregs, such as antigen-specific Chimeric Antigen Receptor (CAR)-Tregs, targeting for example MHC-class I expressed by donor cells.…”
Section: Tolerance Induction In Vcamentioning
confidence: 99%
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