Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo

Tadokoro, Carlos E.; Shakhar, Guy; Shen, Shiqian; Ding, Yi; Lino, Andreia C.; Maraver, Antonio; Lafaille, Juan J.; Dustin, Michael L.

doi:10.1083/jcb1727oia17

Cited by 61 publications

(89 citation statements)

References 23 publications

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“…track transferred T R cells have demonstrated reduced CD4-dendritic cell interaction times and a reduction in the half-life of affected dendritic cells (40). Thus, one way that T R cells may work is by decreasing dendritic cell maturation and function.…”

Section: Discussionmentioning

confidence: 99%

Regulatory T Cells Dynamically Control the Primary Immune Response to Foreign Antigen

Haribhai

Lin

Relland

et al. 2007

The Journal of Immunology

211

223

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The population dynamics that enable a small number of regulatory T (T(R)) cells to control the immune responses to foreign Ags by the much larger conventional T cell subset were investigated. During the primary immune response, the expansion and contraction of conventional and T(R) cells occurred in synchrony. Importantly, the relative accumulation of T(R) cells at peak response significantly exceeded that of conventional T cells, reflecting extensive cell division within the T(R) cell pool. Transfer of a polyclonal T(R) cell population before immunization antagonized both polyclonal and TCR transgenic responses, whereas blocking T(R) cell function enhanced those responses. These results define an inverse quantitative relationship between T(R) and conventional T cells that controls the magnitude of the primary immune response. The high frequency of dividing T(R) cells suggests degenerate TCR specificity enabling activation by a broad spectrum of Ags.

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Section: Discussionmentioning

confidence: 99%

Regulatory T Cells Dynamically Control the Primary Immune Response to Foreign Antigen

Haribhai

Lin

Relland

et al. 2007

The Journal of Immunology

211

223

View full text Add to dashboard Cite

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“…Antigen-specific Tregs have been shown to prevent the interaction between effector T cells and DCs (20, 42). Antigen-specific TGFb-induced Tregs also have been shown to inhibit the expansion of autoreactive effector T cells by acting on DCs and by reducing their ability to present autoantigen in vivo and in vitro (21).…”

Section: Discussionmentioning

confidence: 99%

Analysis of Adhesion Molecules, Target Cells, and Role of IL-2 in Human FOXP3+ Regulatory T Cell Suppressor Function

Tran¹,

Glass²,

Uzel

et al. 2009

The Journal of Immunology

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“…TGFβ, IL-35 and IL-10 (56-58), (ii) cytolytic suppression by secretion of the proteases granzyme-A or granzyme-B (59, 60), (iii) metabolic disruption e.g. by direct transfer of cAMP to effector T cells (61) or by secretion of pericellular adenosine (62), which inhibits effector T cell functions and enhances induced regulatory T cell generation, (iv) suppression of DC maturation and/or function (63) by induction of indoleamine 2,3-dioxygenase, which catalyzes the rate-limiting step in tryptophan catabolism and creates in turn, a shortage of this essential amino acid for effector T cells (64) and (v) by interfering with extracellular reductive redox remodeling by DCs during T cell activation (10). The panoply of suppressive strategies identified to date for regulatory T cell raises questions about their relative importance and how they are integrated in vivo.…”

Section: Regulatory T Cells Interfere With Redox Remodeling By Dendrimentioning

confidence: 99%

Redox Remodeling as an Immunoregulatory Strategy

Yan

Banerjee

2010

Biochemistry

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Activation and proliferation of T cells require a reducing extracellular microenvironment in the immune synapse that is provided by antigen presenting cells especially dendritic cells. Stimulation of dendritic cells by T cells activates the NF-κB pathway in dendritic cells and induces an antioxidant response. It also enhances system x c --dependent cystine uptake, leading to increased glutathione synthesis, export and finally, degradation to cysteine outside the cell. Accumulation of extracellular cysteine supports glutathione synthesis in T cells while also leading to a more reducing redox potential that is needed for T cell proliferation. Naturally occurring regulatory T cells, a suppressor sub-population of T cells, prevent autoimmune diseases and maintain peripheral tolerance by suppressing self-reactive effector T cells. They also suppress beneficial immune responses to parasites, viruses and tumors. However, their mechanism of suppression is still not fully understood. Recently, we have found that inhibition by regulatory T cells of dendritic cell-induced extracellular redox remodeling is a component of the regulatory T cell suppression mechanism. In this review, we describe recent advances in our understanding of redox regulation and signaling in the adaptive immune system with a focus on T cell activation by dendritic cells. The role of regulatory T cells in perturbing redox remodeling by dendritic cells and its implications as a general regulatory T cell suppression mechanism are discussed.

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Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo

Cited by 61 publications

References 23 publications

Regulatory T Cells Dynamically Control the Primary Immune Response to Foreign Antigen

Regulatory T Cells Dynamically Control the Primary Immune Response to Foreign Antigen

Analysis of Adhesion Molecules, Target Cells, and Role of IL-2 in Human FOXP3+ Regulatory T Cell Suppressor Function

Redox Remodeling as an Immunoregulatory Strategy

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