Regulatory T cells induced by B cells: a novel subpopulation of regulatory T cells

Chien, Chien-Hui; Chiang, Bor‐Luen

doi:10.1186/s12929-017-0391-3

Cited by 64 publications

(48 citation statements)

References 93 publications

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“…CD4 + cells can functionally differentiate into various subsets which maintain immune homeostasis. For example, regulatory CD4 + cells include Egr2 + cells, Tr1 cells, and Th3 cells as well as FOXP3 + cells . Although CD4 + cells did not express FOXP3, the presence of other regulatory CD4 + cells was not investigated in the present case.…”

Section: Discussionmentioning

confidence: 85%

Vildagliptin‐induced ground‐glass nodules mimicking lung metastases in a cancer patient receiving Lactobacillus probiotic supplementation

et al. 2020

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The association between gut microbiota and the lung immune system has been attracting increasing interest. Here, we report a case of pancreatic cancer in which the dipeptidyl peptidase-4 inhibitor vildagliptin induced unusual manifestations of interstitial pneumonia, possibly under the influence of Lactobacillus paraplantarum probiotic supplementation. Chest computed tomography and positron emission tomography showed multiple ground-glass nodules (GGNs) mimicking metastatic lung cancer. Transbronchial biopsy specimens showed mild fibrosis and infiltration of lymphocytes consisting of more CD4 + than CD8 + cells. The CD4 + cells did not include FOXP3 + regulatory T cells. Bronchoalveolar lavage confirmed lymphocytosis with a markedly increased CD4 + /CD8 + ratio of 7.4. The nodules disappeared shortly after vildagliptin and probiotics were withheld. If unusual interstitial pneumonia is observed in some cancer patients, physicians should pay careful attention to their medication history, including probiotic supplements.

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Section: Discussionmentioning

confidence: 85%

Vildagliptin‐induced ground‐glass nodules mimicking lung metastases in a cancer patient receiving Lactobacillus probiotic supplementation

et al. 2020

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“…FoxP3 + T reg and IL‐10 + T reg cells are known to play critical roles in control of excessive immune response to maintain the immunohomeostasis and immune tolerance . IL‐10 + B reg cells are also recognized in recent years as important immunosuppressive cells and critical in suppression of immunopathology .…”

Section: Discussionmentioning

confidence: 99%

Critical roles of regulatory B and T cells in helminth parasite-induced protection against allergic airway inflammation

Gao

Ren

Wang

et al. 2019

Clinical and Experimental Immunology

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The prevalence of allergic asthma and incidences of helminth infections in humans are inversely correlated. Although experimental studies have established the causal relation between parasite infection and allergic asthma, the mechanism of the parasite-associated immunomodulation is not fully elucidated. Using a murine model of asthma and nematode parasite Heligmosomoides polygyrus, we investigated the roles of regulatory B cells (B reg ) and T cells (T reg ) in mediation of the protection against allergic asthma by parasite. H. polygyrus infection significantly suppressed ovalbumin (OVA)-induced allergic airway inflammation (AAI) evidenced by alleviated lung histopathology and reduced numbers of bronchoalveolar inflammatory cell infiltration, and induced significant responses of interleukin (IL)-10 + B reg , IL-10 + T reg and forkhead box protein 3 (FoxP3) + T reg in mesenteric lymph node and spleen of the mice. Adoptive transfer of IL-10 + B reg and IL-10 + T reg cell prevented the lung immunopathology in AAI mice. Depletion of FoxP3 + T reg cells in FoxP3-diphtheria toxin (DT) receptor transgenic mice by diphtheria toxin (DT) treatment exacerbated airway inflammationin parasite-free AAI mice and partially abrogated the parasite-induced protection against AAI. IL-10 + B reg cells were able to promote IL-10 + T reg expansion and maintain FoxP3 + T reg cell population. These two types of T regs failed to induce CD19 + B cells to transform into IL-10 + B reg cells. These results demonstrate that B reg , IL-10 + T reg and FoxP3 + T reg cells contribute in A discrepant manner to the protection against allergic airway immunopathology by parasiteS. B reg cell might be a key upstream regulatory cell that induces IL-10 + T reg response and supports FoxP3 + T reg cell population which, in turn, mediate the parasite-imposed immunosuppression of allergic airway inflammation. These results provide insight into the immunological relationship between parasite infection and allergic asthma.

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“…However, several other T‐cell subsets with suppressive activity have been identified. These include CD4 + Foxp3 − T cells that secrete IL‐10, TGF‐β and IL‐35 and are termed Tr1, Th3 and Tr35, respectively . In addition, other suppressive cells not belonging to the Th lineage include CD3 + CD4 − CD8 − double‐negative T cells, Qa‐1‐restricted CD8 Tregs and CD28 lo CD8 + Tregs .…”

Section: Subsets Of Suppressive T Cellsmentioning

confidence: 99%

“…These include CD4 + Foxp3 À T cells that secrete IL-10, TGF-b and IL-35 and are termed Tr1, Th3 and Tr35, respectively. [124][125][126] In addition, other suppressive cells not belonging to the Th lineage include CD3 + CD4 À CD8 À double-negative T cells, Qa-1restricted CD8 Tregs and CD28 lo CD8 + Tregs. [127][128][129] While these additional regulatory T-cell subsets have not been as well studied as the conventional CD4 + Foxp3 + Tregs that are discussed in this review, there is evidence for their protective involvement in renal disease.…”

Section: Subsets Of Suppressive T Cellsmentioning

confidence: 99%

Regulatory T cells in renal disease

et al. 2018

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The kidney is vulnerable to injury, both acute and chronic from a variety of immune and metabolic insults, all of which at least to some degree involve inflammation. Regulatory T cells modulate systemic autoimmune and allogenic responses in glomerulonephritis and transplantation. Intrarenal regulatory T cells (Tregs), including those recruited to the kidney, have suppressive effects on both adaptive and innate immune cells, and probably also intrinsic kidney cells. Evidence from autoimmune glomerulonephritis implicates antigen‐specific Tregs in HLA‐mediated dominant protection, while in several human renal diseases Tregs are abnormal in number or phenotype. Experimentally, Tregs can protect the kidney from injury in a variety of renal diseases. Mechanisms of Treg recruitment to the kidney include via the chemokine receptors CCR6 and CXCR3 and potentially, at least in innate injury TLR9. The effects of Tregs may be context dependent, with evidence for roles for immunoregulatory roles both for endogenous Tbet‐expressing Tregs and STAT‐3‐expressing Tregs in experimental glomerulonephritis. Most experimental work and some of the ongoing human trials in renal transplantation have focussed on unfractionated thymically derived Tregs (tTregs). However, induced Tregs (iTregs), type 1 regulatory T (Tr1) cells and in particular antigen‐specific Tregs also have therapeutic potential not only in renal transplantation, but also in other kidney diseases.

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Regulatory T cells induced by B cells: a novel subpopulation of regulatory T cells

Cited by 64 publications

References 93 publications

Vildagliptin‐induced ground‐glass nodules mimicking lung metastases in a cancer patient receiving Lactobacillus probiotic supplementation

Vildagliptin‐induced ground‐glass nodules mimicking lung metastases in a cancer patient receiving Lactobacillus probiotic supplementation

Critical roles of regulatory B and T cells in helminth parasite-induced protection against allergic airway inflammation

Regulatory T cells in renal disease

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