Regulatory T Cells in the Corpus Luteum—New Players in Fertility Control?

Robertson, Sarah A.

doi:10.1095/biolreprod.111.098301

Cited by 6 publications

(2 citation statements)

References 36 publications

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“…Importantly, a sharp 10-fold decline in CD4 + CD25 + FOXP3 + Treg cells, accompanied by reduced TGFB1 expression, is observed 8 hours after luteolysis triggered by PGF2α administration ( 260 ). This decline in Treg cells may be a direct cause of the shift toward a proinflammatory state, which in turn precedes progesterone decline ( 268 ). Sudden loss of Treg-mediated suppression would be expected to elevate secretion of the proinflammatory cytokines known to inhibit progesterone secretion ( 256 , 269 ) and may accelerate apoptosis-mediated cell death and structural demise.…”

Section: Ovulation and Corpus Luteummentioning

confidence: 99%

Stem Cells, Progenitor Cells, and Lineage Decisions in the Ovary

et al. 2015

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Exploring stem cells in the mammalian ovary has unleashed a Pandora's box of new insights and questions. Recent evidence supports the existence of stem cells of a number of the different cell types within the ovary. The evidence for a stem cell model producing mural granulosa cells and cumulus cells is strong, despite a limited number of reports. The recent identification of a precursor granulosa cell, the gonadal ridge epithelial-like cell, is exciting and novel. The identification of female germline (oogonial) stem cells is still very new and is currently limited to just a few species. Their origins and physiological roles, if any, are unknown, and their potential to produce oocytes and contribute to follicle formation in vivo lacks robust evidence. The precursor of thecal cells remains elusive, and more compelling data are needed. Similarly, claims of very small embryonic-like cells are also preliminary. Surface epithelial cells originating from gonadal ridge epithelial-like cells and from the mesonephric epithelium at the hilum of the ovary have also been proposed. Another important issue is the role of the stroma in guiding the formation of the ovary, ovigerous cords, follicles, and surface epithelium. Immune cells may also play key roles in developmental patterning, given their critical roles in corpora lutea formation and regression. Thus, while the cellular biology of the ovary is extremely important for its major endocrine and fertility roles, there is much still to be discovered. This review draws together the current evidence and perspectives on this topic.

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Section: Ovulation and Corpus Luteummentioning

confidence: 99%

Stem Cells, Progenitor Cells, and Lineage Decisions in the Ovary

et al. 2015

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“…The roles of CD4 + Tregs in the FRS, including maternal-fetal tolerance, have been extensively explored and reviewed elsewhere (111)(112)(113)(114)(115)(116). We will therefore focus on how DNTregs compare with CD4 + Tregs in the FRS.…”

Section: The Female Reproductive System and Dntregs Immune Regulation...mentioning

confidence: 99%

Double Negative T Regulatory Cells: An Emerging Paradigm Shift in Reproductive Immune Tolerance?

2022

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Immune regulation of female reproductive function plays a crucial role in fertility, as alterations in the relationship between immune and reproductive processes result in autoimmune subfertility or infertility. The breakdown of immune tolerance leads to ovulation dysfunction, implantation failure, and pregnancy loss. In this regard, immune cells with regulatory activities are essential to restore self-tolerance. Apart from regulatory T cells, double negative T regulatory cells (DNTregs) characterized by TCRαβ+/γδ+CD3+CD4–CD8– (and negative for natural killer cell markers) are emerging as effector cells capable of mediating immune tolerance in the female reproductive system. DNTregs are present in the female reproductive tract of humans and murine models. However, their full potential as immune regulators is evolving, and studies so far indicate that DNTregs exhibit features that can also maintain tolerance in the female reproductive microenvironment. This review describes recent progress on the presence, role and mechanisms of DNTregs in the female reproductive system immune regulation and tolerance. In addition, we address how DNTregs can potentially provide a paradigm shift from the known roles of conventional regulatory T cells and immune tolerance by maintaining and restoring balance in the reproductive microenvironment of female fertility.

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The Life Cycle of the Ovary

Shen

Zhang

2023

Ovarian Aging

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Regulatory T Cells in the Corpus Luteum—New Players in Fertility Control?

Cited by 6 publications

References 36 publications

Stem Cells, Progenitor Cells, and Lineage Decisions in the Ovary

Stem Cells, Progenitor Cells, and Lineage Decisions in the Ovary

Double Negative T Regulatory Cells: An Emerging Paradigm Shift in Reproductive Immune Tolerance?

The Life Cycle of the Ovary

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