“…However, it is likely that (LEW ϫ AUG)F1 DC are more efficient than recipient (LEW) DC at presenting AUG antigen to LEW T cells, given the high levels of MHC-derived peptides that occupy MHC class II molecule peptide binding grooves (25), which may translate into more powerful indirect regulatory T cell induction. Interestingly, in recent reports published in JASN, regulatory T cells were found to play an important role in mediating indirect (26) but not direct (27) pathway hyporesponsiveness in renal transplant recipients (28).…”