Regulatory T cells in gastric cancer: Key controllers from pathogenesis to therapy

Negura, Ion; Pavel-Tanasa, Mariana; Danciu, Mihai

doi:10.1016/j.ctrv.2023.102629

Cited by 8 publications

(3 citation statements)

References 152 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They regulate the activity of other immune cells through both contact-dependent and cytokine-mediated mechanisms ( 147 ). Dysregulation of Tregs is associated with the onset of various conditions, including autoimmune diseases, allergic reactions, and immune evasion in tumors ( 148 ). When activated by their environment, Tregs can dampen the anti-tumor immune response by releasing inhibitory cytokines like IL-10, IL-35, and TGF-β; thus, fostering tumorigenesis ( 149 , 150 ).…”

Section: The Biological Roles and Functions Of Different Immune Cells...mentioning

confidence: 99%

Recent advances in understanding the immune microenvironment in ovarian cancer

Chen,

Yang,

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

The occurrence of ovarian cancer (OC) is a major factor in women’s mortality rates. Despite progress in medical treatments, like new drugs targeting homologous recombination deficiency, survival rates for OC patients are still not ideal. The tumor microenvironment (TME) includes cancer cells, fibroblasts linked to cancer (CAFs), immune-inflammatory cells, and the substances these cells secrete, along with non-cellular components in the extracellular matrix (ECM). First, the TME mainly plays a role in inhibiting tumor growth and protecting normal cell survival. As tumors progress, the TME gradually becomes a place to promote tumor cell progression. Immune cells in the TME have attracted much attention as targets for immunotherapy. Immune checkpoint inhibitor (ICI) therapy has the potential to regulate the TME, suppressing factors that facilitate tumor advancement, reactivating immune cells, managing tumor growth, and extending the survival of patients with advanced cancer. This review presents an outline of current studies on the distinct cellular elements within the OC TME, detailing their main functions and possible signaling pathways. Additionally, we examine immunotherapy rechallenge in OC, with a specific emphasis on the biological reasons behind resistance to ICIs.

show abstract

Section: The Biological Roles and Functions Of Different Immune Cells...mentioning

confidence: 99%

Recent advances in understanding the immune microenvironment in ovarian cancer

Chen,

Yang,

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…In the diagnosis of GC, the early symptoms of GC are not clear; only symptoms such as epigastric discomfort bear a strong resemblance between diverse chronic diseases like gastritis and gastric ulcer without specificity, leading to a very low detection proportion of early GC ( 5 , 6 ), which is as high as 90%, so more specific and effective ways of GC diagnosis are necessary. Nowadays, the therapy for GC is mainly surgical, combined with perioperative neoadjuvant chemotherapy, adjuvant chemotherapy, radiotherapy, targeted therapy, and other comprehensive means ( 7 , 8 ). However, the initial manifestation of GC often involves subtle clinical symptoms, which, combined with the absence of distinctive diagnostic indicators, implies that a considerable number of patients have already advanced to intermediate and advanced stages of the disease before being diagnosed.…”

Section: Introductionmentioning

confidence: 99%

Exosome-mediated communication between gastric cancer cells and macrophages: implications for tumor microenvironment

Qiu,

Lu,

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Gastric cancer (GC) is a malignant neoplasm originating from the epithelial cells of the gastric mucosa. The pathogenesis of GC is intricately linked to the tumor microenvironment within which the cancer cells reside. Tumor-associated macrophages (TAMs) primarily differentiate from peripheral blood monocytes and can be broadly categorized into M1 and M2 subtypes. M2-type TAMs have been shown to promote tumor growth, tissue remodeling, and angiogenesis. Furthermore, they can actively suppress acquired immunity, leading to a poorer prognosis and reduced tolerance to chemotherapy. Exosomes, which contain a myriad of biologically active molecules including lipids, proteins, mRNA, and noncoding RNAs, have emerged as key mediators of communication between tumor cells and TAMs. The exchange of these molecules via exosomes can markedly influence the tumor microenvironment and consequently impact tumor progression. Recent studies have elucidated a correlation between TAMs and various clinicopathological parameters of GC, such as tumor size, differentiation, infiltration depth, lymph node metastasis, and TNM staging, highlighting the pivotal role of TAMs in GC development and metastasis. In this review, we aim to comprehensively examine the bidirectional communication between GC cells and TAMs, the implications of alterations in the tumor microenvironment on immune escape, invasion, and metastasis in GC, targeted therapeutic approaches for GC, and the efficacy of potential GC drug resistance strategies.

show abstract

“…Cancer, including melanoma and colorectal carcinoma, is currently a serious health challenge worldwide. [1][2][3] Timely surgery, chemotherapy, and radiotherapy are the main strategies for cancer treatment. 4 To date, immunotherapy using RNA molecules, immunostimulatory agents, and immune-checkpoint inhibitors has become an increasingly common type of antitumor treatment.…”

Section: Introductionmentioning

confidence: 99%

Staphylococcus Aureus Membrane Vesicles Kill Tumor Cells Through a Caspase-1-Dependent Pyroptosis Pathway

Li,

Wang,

Liu

et al. 2024

IJN

View full text Add to dashboard Cite

Introduction Nanosized outer membrane vesicles (OMVs) from Gram-negative bacteria have attracted increasing interest because of their antitumor activity. However, the antitumor effects of MVs isolated from Gram-positive bacteria have rarely been investigated. Methods MVs of Staphylococcus aureu s USA300 were prepared and their antitumor efficacy was evaluated using tumor-bearing mouse models. A gene knock-in assay was performed to generate luciferase Antares2–MVs for bioluminescent detection. Cell counting kit-8 and lactic dehydrogenase release assays were used to detect the toxicity of the MVs against tumor cells in vitro. Active caspase-1 and gasdermin D (GSDMD) levels were determined using Western blot, and the tumor inhibition ability of MVs was determined in B16F10 cells treated with a caspase-1 inhibitor. Results The vesicular particles of S. aureus USA300 MVs were 55.23 ± 8.17 nm in diameter, and 5 μg of MVs remarkably inhibited the growth of B16F10 melanoma in C57BL/6 mice and CT26 colon adenocarcinoma in BALB/c mice. The bioluminescent signals correlated well with the concentrations of the engineered Antares2–MVs (R 2 = 0.999), and the sensitivity for bioluminescence imaging was 4 × 10 −3 μg. Antares2–MVs can directly target tumor tissues in vivo, and 20 μg/mL Antares2–MVs considerably reduced the growth of B16F10 and CT26 tumor cells, but not non-carcinomatous bEnd.3 cells. MV treatment substantially increased the level of active caspase-1, which processes GSDMD to trigger pyroptosis in tumor cells. Blocking caspase-1 activation with VX-765 significantly protected tumor cells from MV killing in vitro and in vivo. Conclusion S. aureus MVs can kill tumor cells by activating the pyroptosis pathway, and the induction of pyroptosis in tumor cells is a promising strategy for cancer treatment.

show abstract

Regulatory T cells in gastric cancer: Key controllers from pathogenesis to therapy

Cited by 8 publications

References 152 publications

Recent advances in understanding the immune microenvironment in ovarian cancer

Recent advances in understanding the immune microenvironment in ovarian cancer

Exosome-mediated communication between gastric cancer cells and macrophages: implications for tumor microenvironment

Staphylococcus Aureus Membrane Vesicles Kill Tumor Cells Through a Caspase-1-Dependent Pyroptosis Pathway

Contact Info

Product

Resources

About