Regulatory T cell function correlates with serum 25-hydroxyvitamin D, but not with 1,25-dihydroxyvitamin D, parathyroid hormone and calcium levels in patients with relapsing remitting multiple sclerosis

Smolders, Joost; Menheere, P. P. C. A.; Thewissen, Mariëlle; Peelen, Evelyn; Tervaert, Jan Willem Cohen; Hupperts, Raymond; Damoiseaux, Jan

doi:10.1016/j.jsbmb.2010.03.001

Cited by 67 publications

(54 citation statements)

References 18 publications

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“…There was no correlation in the control group (children without allergy), while in the group of children with allergies a strong, proportional correlation between serum 25-OHD 3 and the percentage of Tregs in the blood have been shown. Similar results in the studies of the correlation of these factors in multiple sclerosis were obtained [30].…”

Section: Examination Of Correlation Between Vitamin D 3 (25-ohd 3 ) Csupporting

confidence: 84%

Clinical immunology Examination of correlation between vitamin D3 (25-OHD3) concentration and percentage of regulatory T lymphocytes (FoxP3) in children with allergy symptoms

Kalicki¹,

Lewicki²,

Stankiewicz³

et al. 2013

cejoi

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Populations of T lymphocytes cells called regulatory T lymphocytes (Tregs) play a key role in the formation and maintenance of immune tolerance. This phenotypically heterogeneous group of cells regulates the immune system and plays an important role in tumor immunology, transplant immunology and the pathogenesis of multiple disorders, in particular autoimmune diseases. In the study it was decided to investigate the difference in the correlation of levels of vitamin D 3 (25-OHD 3 ) with the percentage of Tregs cells (FoxP3+) in children with no symptoms of allergy (control group), and with symptoms of allergy. In addition, in both groups the phenotype of lymphocytes was identified. The results indicate a positive correlation between only in children with allergic symptoms (no correlation in the control group), along with a simultaneous significant reduction in the percentage of CD4 lymphocytes in this group.

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Section: Examination Of Correlation Between Vitamin D 3 (25-ohd 3 ) Csupporting

confidence: 84%

Clinical immunology Examination of correlation between vitamin D3 (25-OHD3) concentration and percentage of regulatory T lymphocytes (FoxP3) in children with allergy symptoms

Kalicki¹,

Lewicki²,

Stankiewicz³

et al. 2013

cejoi

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show abstract

“…This system ensures the regulation of PTH and vitamin D synthesis [13] . Different studies have shown that low vitamin D levels are associated with MS [14][15][16] . Indeed, previous studies have shown that vitamin D has immunomodulatory effects on experimental autoimmune encephalitis, an experimental model of MS; inhibits the IL-12/IFN-γ axis and Th17 cell differentiation; and blocks the entry of inflammatory cells to CNS [32,33] .…”

Section: Klt-fgf-23-vitamin D Axis In Msmentioning

confidence: 99%

“…Several studies have demonstrated the importance of vitamin D in the progression and prevalence of MS. A majority of these studies have shown that vitamin D intake attenuates the progression of MS, and vitamin D has a key role in MS pathogenesis [14,15] . In addition, a lower risk of MS in individuals who are exposed to more sunlight during childhood and early adolescence has supported this theory [16] .…”

Section: Introductionmentioning

confidence: 99%

The Three Sisters of Fate in Multiple Sclerosis: Klotho (Clotho), Fibroblast Growth Factor-23 (Lachesis), and Vitamin D (Atropos)

Elli̇dağ

Yılmaz

Kurtuluş³

et al. 2016

Ann Neurosci

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Background: The klotho (Klt)-fibroblast growth factor-23 (FGF-23)-vitamin D axis is the main component of calcium (Ca) and phosphorus (P) metabolisms; on the contrary, it is also secreted from the choroid plexus (CP). Purpose: This study is aimed at evaluating serum soluble Klt (sKlt), FGF-23, and 25-(OH)-vitamin D levels in multiple sclerosis (MS) patients. Methods: Thirty-two relapsing-remitting MS patients (11 males and 21 females; mean age 38.3 years) and 31 age-sex matched healthy controls (12 males and 19 females; median age 38.5 years) were included in this study. All patients were diagnosed with MS according to the criteria of McDonald. Results: Serum sKlt, FGF-23, and P levels were significantly higher in MS patients compared to the control group (p < 0.01, p < 0.01, and p = 0.02, respectively). Serum 25-(OH)-vitamin D and Ca levels were significantly lower in MS patients (p < 0.01 and p = 0.04, respectively). Conclusion: Klt, which is secreted from CP, could be a response to the inflammatory condition in MS. Elevated FGF-23 levels suppress 1α-hydroxylase and upregulates 24α-hydroxylase, which results in a decrease in 1,25-(OH)₂D₃ levels. Thus, the neuroprotective and immunomodulatory effects of vitamin D might not be seen in MS patients.

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“…The level of 25(OH)D 3 or 1,25(OH) 2 D 3 in the blood is correlated with the suppressive activity of Tregs in MS patients [98,99] , and the number of Tregs is correlated with the serum levels of 25(OH)D 3 and 1,25(OH) 2 D 3 [100] .…”

Section: Vitamin D and Msmentioning

confidence: 99%

Role of vitamin D in immune responses and autoimmune diseases, with emphasis on its role in multiple sclerosis

Zhang

2010

Neurosci. Bull.

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Regulatory T cell function correlates with serum 25-hydroxyvitamin D, but not with 1,25-dihydroxyvitamin D, parathyroid hormone and calcium levels in patients with relapsing remitting multiple sclerosis

Cited by 67 publications

References 18 publications

Clinical immunology Examination of correlation between vitamin D3 (25-OHD3) concentration and percentage of regulatory T lymphocytes (FoxP3) in children with allergy symptoms

Clinical immunology Examination of correlation between vitamin D3 (25-OHD3) concentration and percentage of regulatory T lymphocytes (FoxP3) in children with allergy symptoms

The Three Sisters of Fate in Multiple Sclerosis: Klotho (Clotho), Fibroblast Growth Factor-23 (Lachesis), and Vitamin D (Atropos)

Role of vitamin D in immune responses and autoimmune diseases, with emphasis on its role in multiple sclerosis

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