Regulatory signaling pathways of osteoblast autophagy in periprosthetic osteolysis
YingChu Gu,
ZeRui Wu,
Heng Xie
et al.
Abstract:Periprosthetic osteolysis is a difficult-to-treat complication of arthroplasty. The pathological mechanisms of periprosthetic osteolysis are mainly weakened function of osteoblasts and excessive activation of osteoclasts. Many studies have demonstrated that the imbalance between the formation of bone by osteoblasts and the absorption of bone by osteoclasts is the direct cause of osteolytic diseases. Autophagy, as an important self-protective cellular mechanism, has significant effects on the regulation of oste… Show more
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