Regulatory Roles of B Cells in Allergy and Inflammation

Takatsu, Kiyoshi; Ikutani, Masashi; Nagai, Yoshinori

doi:10.1002/9781444346688.ch6

Cited by 1 publication

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“…B cells play an important role in chronic obstructive pulmonary disease (COPD) progression by secreting autoimmune antibodies that induce lung injury . B cells also contribute to allergic and inflammatory responses. , Therefore, L-BP has a higher potential to trigger allergic and chronic pulmonary inflammation. A heatmap cluster analysis showed that the alterations in CLPs (progenitors of LYs) were different from the other five types of hematopoietic cell subsets (Figure ).…”

Section: Discussionmentioning

confidence: 99%

“… 68 B cells also contribute to allergic and inflammatory responses. 69 , 70 Therefore, L-BP has a higher potential to trigger allergic and chronic pulmonary inflammation. A heatmap cluster analysis showed that the alterations in CLPs (progenitors of LYs) were different from the other five types of hematopoietic cell subsets ( Figure 5 ).…”

Section: Discussionmentioning

confidence: 99%

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Deciphering the Effects of 2D Black Phosphorus on Disrupted Hematopoiesis and Pulmonary Immune Homeostasis Using a Developed Flow Cytometry Method

Wang

et al. 2022

Environ. Sci. Technol.

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As an emerging two-dimensional nanomaterial with promising prospects, mono-or few-layer black phosphorus (BP) is potentially toxic to humans. We investigated the effects of two types of BPs on adult male mice through intratracheal instillation. Using the flow cytometry method, the generation, migration, and recruitment of immune cells in different organs have been characterized on days 1, 7, 14, and 21 post-exposure. Compared with small BP (S-BP, lateral size at ∼188 nm), large BP (L-BP, lateral size at ∼326 nm) induced a stronger stress lymphopoiesis and B cell infiltration into the alveolar sac. More importantly, L-BP dramatically increased peripheral neutrophil (NE) counts up to 1.9-fold on day 21 post-exposure. Decreased expression of the CXCR4 on NEs, an important regulator of NE retention in the bone marrow, explained the increased NE release into the circulation induced by L-BP. Therefore, BP triggers systemic inflammation via the disruption of both the generation and migration of inflammatory immune cells.

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Section: Discussionmentioning

confidence: 99%