Regulatory role of G9a and LSD1 in the Transcription of Olfactory Receptors during Leukaemia Cell Differentiation

Jung, Hyeonsoo; Chae, Yun-Cheol; Kim, Jiyoung; Jeong, Oh-Seok; Kook, Hoon; Seo, Sang-Beom

doi:10.1038/srep46182

Cited by 8 publications

(6 citation statements)

References 60 publications

(93 reference statements)

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“…Unlike most other histone demethylases, which are overexpressed in human cancers [13,[31][32][33], PHF2 is deleted or hypermethylated in its promoter region in breast cancer and downregulated in head and neck cancers [2,3]. In addition, other reports confirm PHF2 is downregulated in colon cancer and involved in the epigenetic regulation of p53 [7].…”

Section: Discussionmentioning

confidence: 92%

Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia

Han

et al. 2017

Epigenomics

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Section: Discussionmentioning

confidence: 92%

Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia

Han

et al. 2017

Epigenomics

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“…Somatic mutation of the genes which play a role in epigenetic regulation of gene expression are described in the advanced form of mastocytosis. So far, however, the potential role and impact of the OTX2-AS1 gene in mastocytosis remain unknown [29].…”

Section: Discussionmentioning

confidence: 99%

Results from a Genome-Wide Association Study (GWAS) in Mastocytosis Reveal New Gene Polymorphisms Associated with WHO Subgroups

Nedoszytko

Sobalska‐Kwapis

Strapagiel

et al. 2020

IJMS

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Mastocytosis is rare disease in which genetic predisposition is not fully understood. The aim of this study was to analyze associations between mastocytosis and single nucleotide polymorphisms (SNPs) by a genome-wide association study (GWAS) approach. A total of 234 patients were enrolled in our study, including 141 with cutaneous mastocytosis (CM; 78 children and 63 adults) and 93 with systemic mastocytosis (SM, all adults). The control group consisted of 5606 healthy individuals. DNA samples from saliva or blood were genotyped for 551 945 variants using DNA microarrays. The prevalence of certain SNPs was found to vary substantially when comparing patients and healthy controls: rs10838094 of 5OR51Q1 was less frequently detected in CM and SM patients (OR = 0.2071, p = 2.21 × 10−29), rs80138802 in ABCA2 (OR = 5.739, p = 1.98 × 10−28), and rs11845537 in OTX2-AS1 (rs11845537, OR = 6.587, p = 6.16 × 10−17) were more frequently detected in CM in children and adults. Additionally, we found that rs2279343 in CYP2B6 and rs7601511 in RPTN are less prevalent in CM compared to controls. We identified a number of hitherto unknown associations between certain SNPs and CM and/or SM. Whether these associations are clinically relevant concerning diagnosis, prognosis, or prevention remains to be determined in future studies.

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“…3g). ORs have been shown to be involved in cell differentiation and carcinogenesis [27]. However, its role in pancreas is unclear.…”

Section: Crosstalk Modules Between Panin and Pdacmentioning

confidence: 99%

Gene modules and non-coding RNAs involved in pancreatic tumorigenesis through acinar ductal metaplasia

Zhang

Shi

Gao

et al. 2020

Preprint

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Background Acinar ductal metaplasia (ADM) can progress through pancreatic ductal carcinoma in situ (PanIN) to pancreatic ductal adenocarcinoma (PDAC). However, the genetic alterations and its transcriptional regulators during the process of ADM-driven PDAC tumorigenesis are largely unknown. Therefore, we applied a multidimensional integration strategy to unveil the gene modules and non-coding RNAs that drives the ADM-PanIN-PDAC process. Methods GSE40895 and the microarray datasets were integrated to unmask the regulators link ADM, PanIN and PDAC. Based on the differential expressed genes and protein–protein interaction (PPI) networks for each stage, Overlap and crosstalk gene modules in ADM-PanIN-PDAC were identified using STRING and Cytoscape. Function of these modules were elucidated by gene ontology analysis. Expression level of hub genes and survival analysis were investigated in human PDAC via GEPIA. MiRDB database was applied to predict potential non-coding RNAs (ncRNAs) capable of regulating overlap and crosstalk genes. Results We found several bridging ADM gene modules (e.g. SMARCA1 and H2AFZ), PanIN gene modules (e.g. HDAC11 and SMARCA2) and PDAC gene modules (e.g. OLFR239 and CLIP3). They were enriched in in nucleosome assembly, chromatin organization and G-protein coupled receptor signaling pathway by GO analysis. MicroRNAs (e.g. mmu-miR-335-5p and mmu-miR-669n) and lncRNAs (e.g. H19 and Gm14207) took part in this ample crosstalk by regulating the gene expression. Conclusions SMARCA1, SMARCA2 and CLIP3 were identified as novel crosstalk genes and significant prognostic biomarkers, providing new insights into ADM-driven PDAC carcinogenesis. Transcriptional regulatory non-coding RNAs targeting crosstalk and overlap genes appear promising for early PDAC intervention.

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Regulatory role of G9a and LSD1 in the Transcription of Olfactory Receptors during Leukaemia Cell Differentiation

Cited by 8 publications

References 60 publications

Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia

Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia

Results from a Genome-Wide Association Study (GWAS) in Mastocytosis Reveal New Gene Polymorphisms Associated with WHO Subgroups

Gene modules and non-coding RNAs involved in pancreatic tumorigenesis through acinar ductal metaplasia

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