Regulatory role of endothelin-1, brain natriuretic peptide and irisin in the development of the immune response to short-term general cooling

Самодова, А. В.; Добродеева, Л. К.; Patrakeeva, V. P.; Shtaborov, V. A.

doi:10.1088/1755-1315/263/1/012039

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“…Адгезивная активность лимфоцитов при относительно высоких концентрациях Nt-pro-BNP в крови также заметно выше, что проявляется снижением их циркулирующих концентраций, преимущественно зрелых и дифференцированных фенотипов. Высвобождающиеся в процессе адгезии и агрегации клеток крови серотонин, гистамин, простагландины, кинины и ацетилхолин [15], содержание которых у лиц, проживающих и работающих в Арктике, заметно выше [16][17][18], обеспечивают миграцию лейкоцитов через сосудистую стенку в ткани. Наиболее рано в регуляцию микроциркуляции включаются эндотелиальные механизмы с секрецией вазоконстриктора эндотелина-1 и окислов азота [19].…”

Section: Discussionunclassified

Blood concentrations of brain natriuretic peptide (Nt-pro-BNP) and the regulation of hemodynamic reactions in healthy adult Arctic residents

Добродеева

Самодова

Balashova

et al. 2023

Ekologiya cheloveka (Human Ecology)

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Introduction: Numerous studies have proven the relationship between the content of brain natriuretic peptide (BNP) in the blood and the problems of cardiovascular insufficiency.Aim: To study the role of changes in Nt-pro-BNP concentrations in the blood in the regulation of hemodynamic reactions in practically adults living and working in the Arctic. Materials and methods. 111 adults (46-55 years old) of practically healthy persons living and working on the Svalbard peninsula, as well as in the villages of Revda and Lovozero of the Murmansk region, including 66 women and 45 men, were examined. The comparison group included 118 healthy adults born and living in the Primorsky district of the Arkhangelsk region, 59 women and 59 men aged 46-55 years.The hemogram in peripheral venous blood, the content of lymphocytes with CD3, CD4, CD8, CD10, CD16, CD19, CD23, CD25, CD71 phenotypes were studied by indirect immunoperoxidase reaction (Sorbent, Moscow) and flow cytometry (Beckman Coulter Immunotech, France); concentrations of Nt-pro-BNP, endothelin-1, total NO, endogenous NO2, nitrate NO3 (RnDSystems, USA), cortisol, norepinephrine, epinephrine (Bender Medsystems, Austria) using enzyme immunoassay. The results are presented as the arithmetic mean and the error of the mean (Mm). For comparison between groups, an independent sample t-test or a nonparametric Mann-Whitney U-test was used, depending on the distribution.Results: In people living in the Arctic and territories equated to the regions of the Far North, the content of the precursor of natriuretic peptide in the venous peripheral blood is higher. Elevated concentrations of Nt-pro-BNP in the blood of Arctic residents are associated with simultaneously higher levels of norepinephrine and cortisol against the background of less pronounced concentrations of adrenaline and endothelin-1, as well as the redistribution of lymphocytes and monocytes from the circulating pool to the marginal one. The established features of hemodynamic reaction regulation are more pronounced in adult Arctic residents and women.Conclusion: The effect of natriuretic peptide is associated with simultaneous activation of the secretion of norepinephrine and cortisol and constitutes a risk of disruption of the mechanisms for maintaining the osmolarity of the internal environment of the body in a very narrow range.

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Section: Discussionunclassified