Regulatory role of adrenergic neurotransmitters on the spontaneous muscular activity in the ruminant trematode <i>Paramphistomum cervi</i> (Paramphistomatidae)

Saikia, Bhaskar; Barua, Chandana Choudhury; Hazarika, Snigdha; Lahon, LC; Saikia, Dilip; Borah, R. C.; Verma, Pawan Kumar

doi:10.1017/s0022149x13000266

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…In veterinary pharmacology the work undertaken by Barua et al ( , 2013Barua et al ( , 2016Barua et al ( , 2017 have been diverse and include in vivo antimycobacterial activity of some folklore medicinal plants of north east Barua et al ( , 2013Barua et al ( , 2016Barua et al ( , 2017. Indepth studies on the antistress activity and molecular mechanism of action of the leaf extract of Elsholtzia communis in rat brain has been undertaken by Barua et al (2017) Studies on the role of adrenergic neurotransmitters on spontaneous muscular activity in ruminant trematode has been conducted by Saikia et al (2014).…”

Section: Faculty and Students From Guahati Medicalmentioning

confidence: 99%

Overview of Pharmacological Research Activities in North Eastern States of India in last 5 Years

Chatterjee

Hazra²

2018

Proceedings of the Indian National Science Academy

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This brief overview intends to shed light on the nature of research activities in the field of pharmacology undertaken mainly by the pharmacology departments of various medical, veterinary and pharmacy colleges from the states of Assam, Manipur, Meghalaya, Sikkim and Tripura. Both experimental and clinical pharmacological research have been undertaken but experiments on identification and validation of diverse pharmacological activities of medicinal plants used as folklore medicines in the north east have been at the forefront. Drug use surveys, disease burden estimation, drug safety monitoring and investigator initiated small scale clinical studies have enriched our knowledge. The contributions have an important bearing on the overall spectrum of pharmacology research in the country while being relevant and sensitive to the needs of the local population. Emphasis on strengthening the research infrastructure as well as building up research manpower capacity are needed to enable greater involvement of the local community in pharmacological research.

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Section: Faculty and Students From Guahati Medicalmentioning

confidence: 99%

Overview of Pharmacological Research Activities in North Eastern States of India in last 5 Years

Chatterjee

Hazra²

2018

Proceedings of the Indian National Science Academy

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Receptor based study of ethanolic seed extract of Butea frondosa Roxb. Ex. Willd for involvement of cholinergic pathway in regulation with NO signaling to establish a potential anti-trematodal drug against Paramphistomum cervi

hazarika,

Barua,

Mohan

et al. 2024

Preprint

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Purpose Reports were found for traditional use of Butea frondosa Roxb. Ex. Willd for nematode infection but its anti-trematodal property and mechanistic action as an anthelmintic is not yet established. Therefore, present study was conducted to evaluate the same as an anti-trematodal agent. Methods Mature and healthy Paramphistomum cervi were collected from the rumen of freshly slaughtered cattle of local abattoir in warm HBSS. For in vitro motility study, six adult P. cervi in each Petri dish having different dilutions of extracts in HBSS ranging from 50, 150, 300, 500, 1000 and 3000 µg/ml and standard Oxyclozanide (10− 5 M) with control receiving only HBSS were taken and incubated at 38 ± 1° C for 5 h. Based on their gross visual motility, ethanolic seed extract of B. frondosa Roxb. Ex. Willd in various concentrations (100, 300, 1000 and 3000 µg/ml) were added to the isometrically mounted P. cervi on isolated tissue bath and their effects on spontaneous muscular activity of P. cervi were estimated. Results Ethanolic seed extract of B. frondosa Roxb. Ex. Willd @ 1000 and 3000 µg/ml showed complete death of worms within 1 hr of exposure which was comparable with the standard drug Oxyclozanide @10− 5 M. For neuropharmacological evaluation on isolated tissue bath, ethanolic seed extract of B. frondosa Roxb. Ex. Willd was found to be hyperpolarizing in nature and caused paralysis and death of worms @ 3000 µg/ml.

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Regulatory role of adrenergic neurotransmitters on the spontaneous muscular activity in the ruminant trematode Paramphistomum cervi (Paramphistomatidae)

Cited by 2 publications

References 16 publications

Overview of Pharmacological Research Activities in North Eastern States of India in last 5 Years

Overview of Pharmacological Research Activities in North Eastern States of India in last 5 Years

Receptor based study of ethanolic seed extract of Butea frondosa Roxb. Ex. Willd for involvement of cholinergic pathway in regulation with NO signaling to establish a potential anti-trematodal drug against Paramphistomum cervi

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