Regulatory principles on food nanoparticles legislated by Asian and Oceanian countries

Mohammadi, Zahra; Jafari, Seid Mahdi

doi:10.1016/b978-0-12-815725-1.00006-9

Cited by 3 publications

(3 citation statements)

References 45 publications

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“…There are attempts worldwide to regulate the manufacture of nanosystems via legislation or guidelines and recommendations [ 305 ]. Currently, there is no legislation exclusively devoted to the regulation of nanosystems in any country [ 306 , 307 , 308 ]. Current FDA guidelines are considered by many countries to be adequate and sufficiently detailed to control lipid nanosystems [ 309 , 310 ]; however, revisions have been recommended by many stakeholders, including the European Parliament [ 311 ] and nongovernmental organisations (NGOs) [ 312 ].…”

Section: Regulatory Aspectsmentioning

confidence: 99%

Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

et al. 2023

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Skin delivery is an exciting and challenging field. It is a promising approach for effective drug delivery due to its ease of administration, ease of handling, high flexibility, controlled release, prolonged therapeutic effect, adaptability, and many other advantages. The main associated challenge, however, is low skin permeability. The skin is a healthy barrier that serves as the body's primary defence mechanism against foreign particles. New advances in skin delivery (both topical and transdermal) depend on overcoming the challenges associated with drug molecule permeation and skin irritation. These limitations can be overcome by employing new approaches such as lipid nanosystems. Due to their advantages (such as easy scaling, low cost, and remarkable stability) these systems have attracted interest from the scientific community. However, for a successful formulation, several factors including particle size, surface charge, components, etc. have to be understood and controlled. This review provided a brief overview of the structure of the skin as well as the different pathways of nanoparticle penetration. In addition, the main factors influencing the penetration of nanoparticles have been highlighted. Applications of lipid nanosystems for dermal and transdermal delivery, as well as regulatory aspects, were critically discussed.

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Section: Regulatory Aspectsmentioning

confidence: 99%

Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

et al. 2023

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“…However, with the widespread industrial application of NPs, their safety has attracted much attention. Previous research has reported that NPs easily penetrate the cell membrane, interact with human cells and tissues, and have potential health risks, given their inherent characteristics. , As a result, various countries have established some policies and regulations on the safety assessment of NPs . Although the safety assessment methods for NPs vary from country to country, they generally follow the methods proposed for food and other materials exposed to food.…”

Section: Introductionmentioning

confidence: 99%

“…5,6 As a result, various countries have established some policies and regulations on the safety assessment of NPs. 7 Although the safety assessment methods for NPs vary from country to country, they generally follow the methods proposed for food and other materials exposed to food. In recent years, numerous studies have gradually focused on the nanotoxicity of the traditional NPs in vivo and in vitro.…”

Section: Introductionmentioning

confidence: 99%

Emerging Nanoparticles in Food: Sources, Application, and Safety

Chen

Guo

Zhang

et al. 2023

J. Agric. Food Chem.

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Nanoparticles (NPs) are small-sized, with high surface activity and antibacterial and antioxidant properties. As a result, some NPs are used as functional ingredients in food additives, food packaging materials, nutrient delivery, nanopesticides, animal feeds, and fertilizers to improve the bioavailability, quality, and performance complement or upgrade. However, the widespread use of NPs in the industry increases the exposure risk of NPs to humans due to their migration from the environment to food. Nevertheless, some NPs, such as carbon dots, NPs found in various thermally processed foods, are also naturally produced from the food during food processing. Given their excellent ability to penetrate biopermeable barriers, the potential safety hazards of NPs on human health have attracted increased attention. Herein, three emerging NPs are introduced including carbon-based NPs (e.g., CNTs), nanoselenium NPs (SeNPs), and rare earth oxide NPs (e.g., CeO 2 NPs). In addition, their applications in the food industry, absorption pathways into the human body, and potential risk mechanisms are discussed. Challenges and prospects for the use of NPs in food are also proposed.

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Laboratory based efficacy of Citrus limon mediated Ag-Pd bimetallic nanoparticles against mosquito larvae

Minal,

Prakash

2024

Preprint

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The current study presents data on the eco-friendly biological synthesis of silver and palladium bimetallic nanoparticles (Ag-Pd BNPs) using a 10% aqueous leaf extract of plant Citrus limon. The synthesized Ag-Pd BNPs were characterized using various techniques, including UV-Visible (UV-Vis) and Fourier transform infrared (FT-IR) spectroscopy, Transmission Electron Microscopy (TEM), Scanning Electron Microscopy and Energy Dispersive X-ray Spectroscopy (SEM-EDX), Dynamic light scattering (DLS), and X-ray diffraction (XRD). Subsequently, the larvicidal nanotoxicity of the characterized Ag-Pd BNPs was assessed against I, II, III, and IV instar larvae of Anopheles stephensi and Aedes aegypti mosquitoes, and its impact on the predation efficiency of non-target nymphs of dragonfly and damselfly was evaluated. The results of UV-Vis displayed a maximum absorption at 300 nm ± 40 nm for the leaf extract, while for the synthesized Ag-Pd BNPs no surface plasmon resonance band was observed. FTIR analysis revealed the involvement of surface functional groups from the leaf extract in nanoparticle synthesis. TEM analysis determined a mean particle size of 21 ± 7.22 d nm, while DLS analysis confirmed a Z-average of 1956 d nm. SEM-EDX verified the presence and purity of the Ag-Pd BNPs in the sample, and XRD analysis identified the leaf extract-mediated synthesis with distinct peaks obtained for Ag and Pd. The nanotoxicity bioassay revealed significant larval mortality and the LC50 values were obtained at the time intervals of 24 h, 48 h, and 72 h of exposure for I to IV instars of both mosquito species. The predation efficiency test against the non-target nymphs of dragonfly and damselfly revealed time-dependent predation dynamics, resulting in high predation rates over specific time intervals. In conclusion, this study offers significant scientific insights into the characterization and ecotoxicological properties of Ag-Pd BNPs, demonstrating their potential under vector control while considering their impact on non-target organisms.

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Regulatory principles on food nanoparticles legislated by Asian and Oceanian countries

Cited by 3 publications

References 45 publications

Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

Emerging Nanoparticles in Food: Sources, Application, and Safety

Laboratory based efficacy of Citrus limon mediated Ag-Pd bimetallic nanoparticles against mosquito larvae

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