Abstract:Edited by Haruki NakamuraMitochondria play an important role in energy conversion as well as in intracellular calcium (Ca 2+ ) storage. Ca 2+ uptake from the cytosol to the mitochondria is mediated by the calcium uniporter, which functions as a Ca 2+ ion channel. However, the molecular composition of this uniporter has remained unclear until recently. The Ca 2+ ion channel consists of seven subunits. The yeast reconstitution technique revealed that the mitochondrial calcium uniporter (MCU) and essential MCU re… Show more
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