Regulatory mechanisms of jaw bone and tooth development

Yuan, Yuan; Chai, Yang

doi:10.1016/bs.ctdb.2018.12.013

Cited by 56 publications

(56 citation statements)

References 118 publications

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“…25 and here on the use of SU5402. That endoderm morphogenesis is essential for normal craniofacial development has been firmly established in numerous papers (57); yet, our data warrant an investigation into whether the midline cells, in addition to the endoderm, play a crucial role. The intimate contact between the apical periderm-like layer and the basal endodermal layer, as well as the long cell processes issuing from the former and contacting the basal lamina (23), provide a further incentive to do so.…”

Section: Pharyngeal Tooth Initiation Requires a Periderm-like Cell Layermentioning

confidence: 58%

Multiple epithelia are required to develop teeth deep inside the pharynx

Oralová

Rosa

Larionova

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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To explain the evolutionary origin of vertebrate teeth from odontodes, it has been proposed that competent epithelium spread into the oropharyngeal cavity via the mouth and other possible channels such as the gill slits [Huysseune et al., 2009,J. Anat.214, 465–476]. Whether tooth formation deep inside the pharynx in extant vertebrates continues to require external epithelia has not been addressed so far. Using zebrafish we have previously demonstrated that cells derived from the periderm penetrate the oropharyngeal cavity via the mouth and via the endodermal pouches and connect to periderm-like cells that subsequently cover the entire endoderm-derived pharyngeal epithelium [Rosa et al., 2019,Sci. Rep.9, 10082]. We now provide conclusive evidence that the epithelial component of pharyngeal teeth in zebrafish (the enamel organ) is derived from medial endoderm, as hitherto assumed based on position deep in the pharynx. Yet, dental morphogenesis starts only after the corresponding endodermal pouch (pouch 6) has made contact with the skin ectoderm, and only after periderm-like cells have covered the prospective tooth-forming endodermal epithelium. Manipulation of signaling pathways shown to adversely affect tooth development indicates they act downstream of these events. We demonstrate that pouch–ectoderm contact and the presence of a periderm-like layer are both required, but not sufficient, for tooth initiation in the pharynx. We conclude that the earliest interactions to generate pharyngeal teeth encompass those between different epithelial populations (skin ectoderm, endoderm, and periderm-like cells in zebrafish), in addition to the epithelial–mesenchymal interactions that govern the formation of all vertebrate teeth.

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Section: Pharyngeal Tooth Initiation Requires a Periderm-like Cell Layermentioning

confidence: 58%

Multiple epithelia are required to develop teeth deep inside the pharynx

Oralová

Rosa

Larionova

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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“…Skeletal formation in the maxillofacial area proceeds with differentiation of neural crest cells (NCCs) migrating from the dorsal part of the developing neural tube into chondrocytes and osteoblasts in the pharyngeal arches (PAs) . Previous studies using various model animals have revealed that craniofacial morphogenesis requires reciprocal interaction by signaling cascades among the NCC, mesoderm, endodermal pouch, and ectodermal epithelium in PAs . The generation and proliferation of NCCs appear to be particularly sensitive to perturbation, which is suggested by investigation of the Treacher Collins syndrome model mouse ( see also Section 3).…”

Section: Introductionmentioning

confidence: 99%

Heterozygous mutation of the splicing factor Sf3b4 affects development of the axial skeleton and forebrain in mouse

Yamada

Takechi

Yokoyama

et al. 2020

Developmental Dynamics

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Background: Splicing factor 3B subunit 4 (SF3B4) is a causative gene of an acrofacial dysostosis, Nager syndrome. Although in vitro analyses of SF3B4 have proposed multiple noncanonical functions unrelated to splicing, less information is available based on in vivo studies using model animals. Results:We performed expression and functional analyses of Sf3b4 in mice. The mouse Sf3b4 transcripts were found from two-cell stage, and were ubiquitously present during embryogenesis with high expression levels in several tissues such as forming craniofacial bones and brain. In contrast, expression of a pseudogene-like sequence of mouse Sf3b4 (Sf3b4_ps) found by in silico survey was not detected up to embryonic day 10. We generated a Sf3b4 knockout mouse using CRISPR-Cas9 system. The homozygous mutant mouse of Sf3b4 was embryonic lethal. The heterozygous mutant of Sf3b4 mouse (Sf3b4 +/− ) exhibited smaller body size compared to the wild-type from postnatal to adult period, as well as homeotic posteriorization of the vertebral morphology and flattened calvaria. The flattened calvaria appears to be attributable to mild microcephaly due to a lower cell proliferation rate in the forebrain. Conclusions:Our study suggests that Sf3b4 controls anterior-posterior patterning of the axial skeleton and guarantees cell proliferation for forebrain development in mice. K E Y W O R D Shomeotic posteriorization, microcephaly, Nager syndrome, splicing factor Takahiko Yamada and Masaki Takechi contributed equally to this study.

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“…This situation suggests the presence of correlations between the introduction of pulsed short wave therapy shortly after completion of periodontal curettage, considering the more pronounced mineralization of alveolar bone processes, compared to the rest of the jaw bone structures. Another theory is that according to which teeth are bone growth and development centers (23); in this sense, activation of cellular enzymatic reactions and of the periodontal connective-vascular system stimulates periodontal bone regeneration (Figs. 8, 9).…”

Section: A B Cmentioning

confidence: 99%

Pulsed short waves in the remineralization of alveolar bone structures of the jaw in patients with diabetes mellitus – a series of cases

Alexandru

Popa

Dogaru

et al. 2019

BALNEO

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This clinical study included three patients aged between 50 and 78 years who had chronic marginal periodontitis and type 2 diabetes mellitus, diseases that are frequently associated due to changes occurring in polymorphonuclear cells, as well as to alterations of microcirculation. No bone augmentation therapies were performed. Bone regeneration was strictly influenced by conventional periodontal therapy, supplemented with ten pulsed short wave sessions applied to the lower face shortly after closed periodontal curettage. The allocated time was ten minutes for the first two sessions, and 15 minutes for the following 8 sessions. Clinical and radiological evaluations were performed at the time of presentation, as well as after initiation of pulsed short wave therapy: in the first case, three weeks after initiation of therapy and three years after the end of complex oral rehabilitation; in the second case, eight weeks after the onset of pulsed short wave therapy and in the third case, five weeks after the onset of pulsed short wave therapy. The results were significant in all three cases, demonstrated radiologically by the same type of radiological examination at identical scales. Bone remineralization was obvious in the alveolar processes of the jaw. Although further studies in this direction are necessary, the results are both clinically and radiologically significant. Key words: pulsed short waves, alveolar bone resorption, periodontal disease, diabetes,

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Regulatory mechanisms of jaw bone and tooth development

Cited by 56 publications

References 118 publications

Multiple epithelia are required to develop teeth deep inside the pharynx

Multiple epithelia are required to develop teeth deep inside the pharynx

Heterozygous mutation of the splicing factor Sf3b4 affects development of the axial skeleton and forebrain in mouse

Pulsed short waves in the remineralization of alveolar bone structures of the jaw in patients with diabetes mellitus – a series of cases

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