Regulatory Mechanisms of Cell‐Mediated Immunity in Allogeneic Pregnancy

Abstract

The transfer of cells from allopregnant animals to syngeneic receivers allografted with paternal strain tumor leads to mild but significant enhancement. The effect can be defined as T cell mediated. Cells from allopregnant animals can suppress a mixed lymphocyte reaction (MLR) of maternal responders against paternal stimulators. The effect relies upon a THY 1+, Ly 2+, Ia+ cell. Cell-mediated lympholysis (CML) assay could also be suppressed by cells from allopregnant animals. Placental products are capable of interfering with allograft rejection in vivo. They can block MLR in vitro, and seem to act in part via the induction of suppressor cells. The respective roles of these depressive components, together with enhancing antibodies, is discussed.

Tolerance Signaling Molecules and Pregnancy: IDO, Galectins, and the Renaissance of Regulatory T Cells

“…The suppressor T cells were found in the spleen 47,49,50 , placenta 48 , uterine blood, and deciduas 52 as well as the draining lymph nodes of the uterus 53 . They were thought to express the surface marker Ly‐2 (CD8α) and in some experiments exhibited allo‐antigen specificity 54,55,56 …”