Regulatory gene adaptation: An evolutionary model

Hedrick, Philip W.; McDonald, John F.

doi:10.1038/hdy.1980.52

Cited by 58 publications

(28 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, we may contrast the divergence of many genes to produce hybrid inviability with the lack of electrophoretic divergence; 20 enzyme loci have been studied, six of them polymorphic, but no difference between the two races has been detected (Halliday, Barton, and Hewitt, unpublished). It has been argued that the lack of a strict correlation between electrophoretic divergence and speciation shows that isolation must be due to "regulatory" loci, or to DNA sequences that do not code for proteins (Wilson et al, 1974;Hedrick and McDonald, 1980). However, this argument is not supported by the Podisma data, for several reasons.…”

Section: Discussionmentioning

confidence: 99%

The genetic basis of hybrid inviability in the grasshopper Podisma pedestris

Barton¹,

Hewitt

1981

Heredity

View full text Add to dashboard Cite

SUMMARYSamples were taken from five sites in a transect across the hybrid zone between two chromosomal races of the grasshopper Podisma pedestris. Crosses were set up between insects from the same population, and between populations spanning the zone, and the early viability of the offspring was measured. Hybrids between pure populations had reduced viability, and the viability of insects from the middle of the zone was still lower, showing that most (-87 per cent) of the inviability was due to the breakup of coadapated gene complexes. Although the total selection acting was strong (log, fitness reduced by S -25), it was spread over a region wider than the dispersal range (350 m vs. 20 m). Hence, the selection on each locus contributing towards the inviability is weak (-3 per cent). Many (-150) independent chromosome segments act cumulatively to produce inviability at this stage in the life history. The implications of these findings for models of divergence are discussed.

show abstract

Section: Discussionmentioning

confidence: 99%

The genetic basis of hybrid inviability in the grasshopper Podisma pedestris

Barton¹,

Hewitt

1981

Heredity

View full text Add to dashboard Cite

show abstract

“…Under such strong selection intensity, genes with major effects are required for individuals to colonize, or to persist in, the pesticide-treated environments (Hedrick & McDonald, 1980;Wright, 1982;Lande, 1983;Charlesworth, 1990;Macnair, 1991; McKenzie & Batterham, 1994;Jasieniuk et a!., 1995). Accordingly, in the field, the evolution of resistance to insecticides appears to be mostly the result of the action of one or a few genes with major effects, and secondarily of genes with minor effects (Wood, 1981;Roush & McKenzie, 1987;Tabashnik *Correspondence.…”

Section: Introductionmentioning

confidence: 99%

Change in genetic architecture resulting from the evolution of insecticide resistance: a theoretical and empirical analysis

Carrière

Roff

1995

Heredity

View full text Add to dashboard Cite

Under selection for insecticide resistance, the spread of a major resistance allele that has strong pleiotropic effects on life history characters will affect the genetic architecture of fitness. A model is developed showing that the spread of such an allele induces a change in the mean and in the additive genetic variance (heritability) of the life history characters, and in the genetic covariance (correlation) between these characters. The model was tested using a quantitative genetic study that compared, in a lepidopteran species (Choristoneura rosaceana), the genetic architecture of diapause propensity and larval weight within and among insecticidefree and insecticide-treated populations from the same geographical area. Significant genetic correlations between resistance to the insecticides and the life history traits were found within the populations, suggesting that the resistance allele(s) has pleiotropic effects on the life history characters. As resistance develops from an initial value of zero, the model predicts a positive relationship between the degree of resistance within the populations and, (1) the magnitude of the fitness costs, (2) the heritability of the life history traits, and (3) the absolute value of the genetic correlations between pairs of life history traits. All these predictions were confirmed. Moreover, the evolution of resistance apparently affected the environmental variance in larval weight. Hence, the novel evolution of insecticide resistance appears to result in major changes in the genetic architecture of fitness, which may limit to some extent the colonization of insecticide-treated habitats.

show abstract

“…It has been proposed that changes in gene regulation are important in adaptive evolution, perhaps more so than changes in protein structure (King and Wilson, 1975;Valentine and Campbell, 1975;Wilson, 1976;Hedrick and McDonald, 1980;Maclntyre, 1982). However, the evidence advanced in support of this view is largely indirect.…”

Section: Introductionmentioning

confidence: 99%

Regulatory gene evolution: Adaptive differences in expression of alcohol dehydrogenase in Drosophila melanogaster and Drosophila simulans

1984

View full text Add to dashboard Cite

SUMMARYIn Drosophila melanogaster x D. simulans hybrids, the alcohol dehydrogenase (ADH) electromorphs characteristic of the two parents display tissue-and stage-specific differences in relative level of expression. This implies distinct cis-acting regulatory elements associated with the respective Adh alleles. These cis-acting elements account in part, but not completely, for markedly different overall patterns of ADH expression in the two species. The regulatory patterns seem to be adaptively significant since they correlate with species-specific patterns of ethanol tolerance. The activity differences are accounted for by different levels of enzyme protein, but the underlying mechanisms have not been fully analysed and may be complex. Independent evolution of various aspects of the ADH developmental programme may relate to use of different promoters for transcription of the Adh locus in different developmental contexts. This system illustrates the potential importance of regulatory genes in evolution and provides a model for investigating the molecular basis of evolved regulatory differences.

show abstract

Regulatory gene adaptation: An evolutionary model

Cited by 58 publications

References 34 publications

The genetic basis of hybrid inviability in the grasshopper Podisma pedestris

The genetic basis of hybrid inviability in the grasshopper Podisma pedestris

Change in genetic architecture resulting from the evolution of insecticide resistance: a theoretical and empirical analysis

Regulatory gene evolution: Adaptive differences in expression of alcohol dehydrogenase in Drosophila melanogaster and Drosophila simulans

Contact Info

Product

Resources

About