Regulatory effects of interleukin-4 on tumor-infiltrating lymphocytes derived from human renal cell carcinoma

Peyret, C; Bochner, Bernard H.; Lee, Tchun Y.; Koo, Alec S.; deKernion, Jean B.; Belldegrun, Arie S.

doi:10.1016/0022-4804(92)90261-w

Cited by 2 publications

(1 citation statement)

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“…Nierenzellkarzinom · Zytokinproduktion · Immunmodulation · Prognosefaktoren InderBehandl ung des Nierenzellkarzinoms (NZK) kommen in Ergänzung der radikalen Tumorchirurgie zunehmend immunologische Therapieansätze zum Einsatz, da der Tumor gegen Chemo-und Strahlentherapie weitgehend resistent ist [13].…”

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Lymphocyte transformation test (LTT) - a model for testing the cytokine-induced immunomodulatory capacity of renal cell carcinoma

et al. 1998

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We investigated the immunomodulatory capacity of cytokines produced by renal cell carcinoma in vitro by analyzing their effects on mitogen-induced T-lymphocyte blast cell transformation. All of the tested 70 cell cultures, derived from 70 tumor areas in 33 patients, had immunomodulatory capacity. In addition to suppression in the lymphocyte transformation test (max. 44/70; 63%) there was also superinduction (max. 37/70; 53%). We found no significant correlation with the stage and grade of primary tumors. However, the suppression of mitogen-induced T-lymphocyte blast cell transformation was significant in multifocal tumors (0.08% TCM, P < 0.001) and non-significant in metastatic tumors. The production of the assayed cytokines IL-6, IL-10, IL-11, and TGF beta 1 was variable and there was no significant correlation to the immunomodulatory capacity of the tumors.

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