Regulatory effects of <i>Lactobacillus plantarum</i>-GMNL6 on human skin health by improving skin microbiome

Tsai, Wan-Hua; Chou, Chia-Hsuan; Chiang, Ying-Ju; Lin, Ching-Gong; Lee, Che‐Hsin

doi:10.7150/ijms.51545

Cited by 49 publications

(48 citation statements)

References 17 publications

(13 reference statements)

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“…Treatment with L. plantarum THG-10 in vitro decreases the growth of C. acnes and nitric oxide production, which is induced by the inflammation process [23]. Furthermore, results from topically applied studies in female subjects indicate that L. plantarum-GMNL6 reduces erythema and the proportion of Propionibacterium genus in the face [14]. In this study, we demonstrated that L. plantarum CJLP55 supplement decreased the clinical severity of acne.…”

Section: Discussionsupporting

confidence: 49%

“…Lactobacillus, a well-characterized genus in LAB, is beneficial for skin health improvement [7,8]. Specifically, various strains of L. plantarum have been reported to improve acne vulgaris with broad anti-inflammatory and anti-pathogenic bacterial activities as well as with modulation of bacterial flora in the skin [12,14,23]. Topically applied L. plantarum on the face of patients with mild acne vulgaris reduces acne lesion size and erythema [12].…”

Section: Discussionmentioning

confidence: 99%

“…In fact, L. rhamnosus SP1 supplement decreases clinical severity and IGF-1 mRNA expression in the skin of acne patients [38]. However, the beneficial effects of various strains of L. plantarum on decreased acne severity and sebum production have been reported mostly from topically applied and in vitro studies [12,14,23], and little information is available on the relationship between ingested L. plantarum and altered levels of insulin, IFG-1 and BCAA in either the serum or skin of acne patients. Alternatively, L. plantarum CJLP55 has been reported to have immunomodulation effects with altered cytokine production [10,11].…”

Section: Discussionmentioning

confidence: 99%

“…Orally administered L. plantarum CJLP55 decreases the production of IL-4 and IL-5 in lymph nodes and relieves atopic dermatitis (AD)-like skin lesions in NC/Nga mice [11]. In addition, ingested or topically applied L. plantarum modulates bacterial flora in the intestine as well as in the skin [12][13][14]. However, bacteria might not be disseminated in the body and barely reach directly to the skin [15].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of Lactobacillus plantarum CJLP55 on Clinical Improvement, Skin Condition and Urine Bacterial Extracellular Vesicles in Patients with Acne Vulgaris: A Randomized, Double-Blind, Placebo-Controlled Study

Kim

Choi

et al. 2021

Nutrients

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Lactobacillus plantarum CJLP55 has anti-pathogenic bacterial and anti-inflammatory activities in vitro. We investigated the dietary effect of CJLP55 supplement in patients with acne vulgaris, a prevalent inflammatory skin condition. Subjects ingested CJLP55 or placebo (n = 14 per group) supplements for 12 weeks in this double-blind, placebo-controlled randomized study. Acne lesion count and grade, skin sebum, hydration, pH and surface lipids were assessed. Metagenomic DNA analysis was performed on urine extracellular vesicles (EV), which indirectly reflect systemic bacterial flora. Compared to the placebo supplement, CJLP55 supplement improved acne lesion count and grade, decreased sebum triglycerides (TG), and increased hydration and ceramide 2, the major ceramide species that maintains the epidermal lipid barrier for hydration. In addition, CJLP55 supplement decreased the prevalence of Proteobacteria and increased Firmicutes, which were correlated with decreased TG, the major skin surface lipid of sebum origin. CJLP55 supplement further decreased the Bacteroidetes:Firmicutes ratio, a relevant marker of bacterial dysbiosis. No differences in skin pH, other skin surface lipids or urine bacterial EV phylum were noted between CJLP55 and placebo supplements. Dietary Lactobacillus plantarum CJLP55 was beneficial to clinical state, skin sebum, and hydration and urine bacterial EV phylum flora in patients with acne vulgaris.

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Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Lactobacillus plantarum CJLP55 on Clinical Improvement, Skin Condition and Urine Bacterial Extracellular Vesicles in Patients with Acne Vulgaris: A Randomized, Double-Blind, Placebo-Controlled Study

Kim

Choi

et al. 2021

Nutrients

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“…plantarum GMNL6 has been associated with higher amounts of Staphylococcus spp. [ 58 ]. Therefore, Lc.…”

Section: Discussionmentioning

confidence: 99%

Improvement of Cutaneous Wound Healing via Topical Application of Heat-Killed Lactococcus chungangensis CAU 1447 on Diabetic Mice

et al. 2021

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Cutaneous wound healing comprises a complex systemic network. Probiotics, naturally extracted substances, medicine, and chemical compounds have been used for wound healing, but the application of postbiotics as therapeutic agents has yet to be explored. Our study shows potential beneficial effects of heat-killed Lactococcus chungangensis CAU 1447 on type 1 diabetic mice. The postbiotic strain significantly decreased the skin wound size. The activity of myeloperoxidase secreted from neutrophils also decreased. The molecular mechanism of wound healing was adjusted by important mediators, growth factors, chemokines, and cytokines. These elements regulated the anti-inflammatory activity and accelerated wound healing. To determine the role of the postbiotic in wound repair, we showed a similar taxonomic pattern as compared to the diabetic mice using skin microbiome analysis. These findings demonstrated that heat-killed Lactococcus chungangensis CAU 1447 had beneficial effects on wound healing and can be utilized as postbiotic therapeutic agents.

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Safety and Effectiveness of Oral Nutraceuticals for Treating Acne

Shields,

Ly,

Wafae

et al. 2023

JAMA Dermatol

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ImportancePatients with acne are interested in nutraceuticals as a potential treatment option. However, there is uncertainty regarding the efficacy and safety of these products.ObjectiveTo evaluate the evidence for oral nutraceuticals in the treatment of acne.Evidence ReviewThe PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science databases were searched from inception through January 30, 2023, to identify randomized clinical trials evaluating oral nutraceutical interventions (ie, vitamins and minerals, botanical extracts, prebiotics, and probiotics) in individuals with acne. Clinician-reported outcomes (eg, investigator global assessment, lesion counts), patient-reported outcomes (eg, quality of life), and adverse events were extracted from the included studies. The quality of evidence was assessed using the Cochrane Risk of Bias checklist tool for randomized clinical trials. Based on the Risk of Bias tool, articles were converted to Agency for Healthcare Research and Quality standards of good, fair, or poor quality.FindingsA total of 2582 abstracts were identified in the database search, 42 of which met inclusion criteria (a total of 3346 participants). Studies of fair or good quality showed the potential benefit of vitamins B5 and D, botanical extracts (green tea), probiotics, and ω-3 fatty acids in the treatment of acne. These interventions were most frequently associated with decreased lesion counts or improved investigator global assessment scores. Adverse effects were rare for most of the therapies evaluated, but gastrointestinal tract adverse effects were reported for zinc therapy.Conclusions and RelevanceThis systematic review suggests a possible role for nutraceutical supplements in the treatment of acne. Physicians should be prepared to discuss the evidence regarding the potential role of nutraceuticals with patients. Many studies were of small size, and future research should focus on larger randomized clinical trials to assess the utility of nutraceuticals in the treatment of acne.

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Regulatory effects of Lactobacillus plantarum-GMNL6 on human skin health by improving skin microbiome

Cited by 49 publications

References 17 publications

Effects of Lactobacillus plantarum CJLP55 on Clinical Improvement, Skin Condition and Urine Bacterial Extracellular Vesicles in Patients with Acne Vulgaris: A Randomized, Double-Blind, Placebo-Controlled Study

Effects of Lactobacillus plantarum CJLP55 on Clinical Improvement, Skin Condition and Urine Bacterial Extracellular Vesicles in Patients with Acne Vulgaris: A Randomized, Double-Blind, Placebo-Controlled Study

Improvement of Cutaneous Wound Healing via Topical Application of Heat-Killed Lactococcus chungangensis CAU 1447 on Diabetic Mice

Safety and Effectiveness of Oral Nutraceuticals for Treating Acne

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