Regulatory effects of four ginsenoside monomers in humoral immunity of systemic lupus erythematosus

Abstract

Abstract. Ginsenosides Rb1, Rh1, Rg1 and Rg3 are known as the main active components extracted from the roots of the Panax ginseng C.A. Meyer, and were reported to have immunoregulatory effects. Disruption of B-cell immune regulation during the pathogenesis of systemic lupus erythematosus (SLE) may lead to the production of large amounts of antibodies. The present study investigated the effects of the four ginsenoside monomers on B-cell immune regulation and observed that they inhibited the proliferation and secretion of B cells induced by LPS, caused an upregulation of the expression of apoptosis-associated proteins Fas/Fas ligand and caspase-3, the expression of FcγRIIB (CD32) as well as the proportion of inactive B cells (CD19 + CD27 -). These results indicate that Rb1, Rh1, Rg1 and Rg3 inhibit the humoral immunity of SLE, among which Rh1 exhibited the most obvious inhibitory effect.

Adaptogenic effects of Panax ginseng on modulation of immune functions

“…Ginsenosides Rb1, Rh1, Rg1, and Rg3 downregulated the humoral immunity related to systemic lupus erythematosus blocking B-cell secretion and proliferation. Highly pruritic chronic inflammatory disease named atopic dermatitis (AD), elevates serum IgE levels, and markedly increases levels of inflammatory cells [ 83 ]. The equipoise of Th1 and Th2 is crucial regarding the pathogenesis of AD from an immunological perspective, and controlling the delicate equilibrium among Th1, Th2, and Th17/22 and T-reg cells is crucial to the control of AD.…”

“…Cho et al suggested KRG can serve preventive as well as therapeutic functions through modulating the immune network at the early stages of AD. Oral KRG has been shown to obstruct the progression of the cutaneous inflammation in an AD animal model by hindering the DCs, thymic stromal lymphopoietin, and Th2 cytokines [ 83 ].…”

Herbal Active Ingredients: Potential for the Prevention and Treatment of Acute Lung Injury

“…Ginsenosides form a class of steroid glycosides and triterpene saponins. As the main active ingredients in Ginseng radix, they have various pharmacological effects, such as immunity enhancement and antiageing and antitumor effects [34][35][36]. Ginsenosides include Rb1, Rg1, Rg3, GRh2, and other monomeric saponins.…”

Bioactive Ingredients in Chinese Herbal Medicines That Target Non-coding RNAs: Promising New Choices for Disease Treatment

“…Mey., a valuable herb with nourishing effects and a long history of use in ancient China. At present, GS products are not only used to promote health, but also for their activity as immune regulators in many diseases (Jiang Z. et al, 2017; Shin et al, 2018; Yu X. et al, 2018). GS exert a cytoprotective effect, thereby promoting cell viability on avian influenza H9N2/G1 infection.…”