Abstract:Background Pulmonary ischemia/reperfusion (I/R) injury derived from hemorrhagic shock-resuscitation is a significant cause of death in trauma patients. However, effective preventive interventions in early trauma resuscitation are lacking.
Aims To investigate the critical role of the HMGB1-TLR4 pathway in the early inflammatory response after ischemia-reperfusion lung injury, and its specific regulatory mechanisms and the types of downstream cytokines regulated by this pathway.
Methods In this study, to determi… Show more
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