Regulatory effect of m⁶A modification on different viruses

Abstract

N 6 -methyladenosine (m 6 A) modification is the most common and reversible posttranscriptional modification of RNA in eukaryotes, which is mainly regulated by methyltransferase, demethylase, and specific binding protein. The replication of the virus and host immune response to the virus are affected by m 6 A modification. In different kinds of viruses, m 6 A modification has two completely opposite regulatory functions. This paper reviews the regulatory effects of m 6 A modification on different viruses and provides a reference for studying the regulatory effects of RNA epitranscriptomic modification.

Identification and Characterization of BmNPV m6A Sites and Their Possible Roles During Viral Infection

“…These results suggest that BmYTHDF3 suppressed the BmNPV infection in BmN cells via recognizing the m6A sites in viral genes. The m6A modification system has different regulatory mechanisms for different viruses ( 45 , 47 ). The appearance of m6A modification on viral RNA will be used as a molecular marker for evading host innate immune recognition of non-self RNA ( 28 ).…”

EBV Exploits RNA m6A Modification to Promote Cell Survival and Progeny Virus Production During Lytic Cycle

“…m 6 A modification is a type of post-transcriptional modification conserved in many species, including yeast, plants, and mammals, and is involved in many biological processes. The RNAs of viruses—such as HIV, HCV, influenza A virus, respiratory syncytial virus, vesicular stomatitis virus, enterovirus 71, zika virus, dengue virus, severe acute respiratory syndrome coronavirus 2, hepatitis B virus, KSHV, human cytomegalovirus, herpes simplex virus, and adenovirus—also undergo such methylation (Baquero-Perez et al, 2021 ; Yu et al, 2021 ). However, the effect of m 6 A modification on viral replication varies according to the virus species and cell type.…”

Dynamic transcriptome analyses reveal m6A regulated immune non-coding RNAs during dengue disease progression

“…Moreover, it is important to identify the potential regulatory factors that regulate the expression of genes and lncRNAs. N 6 -methyladenosine (m6A) is the most abundant modification and it regulates RNA transcription, processing, splicing, degradation, and translation [ 16 , 17 ]. The m6A modification has been identified as an important regulator in regulating expression of lncRNAs [ 18 , 19 ].…”