Regulatory effect of long-stranded non-coding RNA-CRNDE on neurodegeneration during retinal ischemia-reperfusion

Long Noncoding RNA MIAT Modulates Chronic Retinal Ischemia-Reperfusion Injury in Mice via the microRNA-203-3p/SNAI2 Axis

“…For example, lncRNA Ttc3-209 is up-regulated after I/R injury and performs a proapoptotic role in RGCs during I/R-induced apoptosis, which provides a new therapeutic option for preventing RGC apoptosis in response to RIRI . Also, lncRNA CRNDE knockdown alleviates retinal neurodegeneration induced by RIRI, as shown by decreased reactive gliosis and reduced retinal cell loss . Therefore, we aimed to study the effects of MIAT on RIRI.…”

“…7 Also, lncRNA CRNDE knockdown alleviates retinal neurodegeneration induced by RIRI, as shown by decreased reactive gliosis and reduced retinal cell loss. 8 Therefore, we aimed to study the effects of MIAT on RIRI. Recently, evidence has shown that MIAT is decreased in the diabetic retina upon injection of human umbilical cord mesenchymal stem cells, and MIAT has emerged as a crucial player in regulating inflammatory processes and microvascular dysfunction induced by DR. 31 It is also reported that MIAT has been implicated as a vital regulator of microvascular dysfunction in DR, which enhances a better recognition of novel therapeutic regimens for DR treatment.…”

“…Long noncoding RNAs (lncRNAs) have an association with various biological processes and with increasing disorders, controlling the transcription of genes, the processing of pre-mRNAs, mRNA stability modulation, protein translation, and turnover . LncRNAs, such as lncRNA-H19 and Ttc3-209, can function as important players and uncover specific mechanisms in RIRI, which can potentially act as therapeutic targets. , IR is characterized by neurodegeneration and microvascular dysfunction . It is reported that lncRNA myocardial infarction-associated transcript (MIAT) has a role in microvascular dysfunction .…”

“…1,7 IR is characterized by neurodegeneration and microvascular dysfunction. 8 It is reported that lncRNA myocardial infarctionassociated transcript (MIAT) has a role in microvascular dysfunction. 9 More specifically, lncRNA MIAT, serving as a competing endogenous RNA, is able to regulate microvascular dysfunction.…”

A lncRNA-disease association prediction model based on the two-step PU learning and fully connected neural networks

“…For example, lncRNA H19 has been shown to increase the HMGA2-mediated epithelial-mesenchymal transformation (EMT) in pancreatic ductal adenocarcinoma (PDAC) by antagonizing let-7, at least partially promoting PDAC cells [ 9 ]. In the future, lncRNA is expected to become a new biomarker to study the pathogenesis of diseases and guide disease treatment [ [10] , [11] , [12] , [13] , [14] ]. Therefore, it is of great significance to study the associations between lncRNA and diseases.…”