Regulatory Effect of Hydrogen Sulfide on Vascular Collagen Content in Spontaneously Hypertensive Rats

Zhao, Xia; Zhang, Like; Zhang, Chunyu; Zhang, Xiangjun; Yan, Hui; Jin, Hang; Tang, Chaoshu; Du, Junbao

doi:10.1291/hypres.31.1619

Cited by 99 publications

(78 citation statements)

References 35 publications

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“…27 NaHS inhibited angiotensin II-induced vascular smooth muscle cell proliferation and collagen generation in spontaneously hypertensive rats. 28 Therefore, the effects of H2S on smooth muscle cells may also contribute to augmenting ischemia-induced angiogenesis in part.…”

Section: Discussionmentioning

confidence: 99%

Diallyl Trisulfide Augments Ischemia-Induced Angiogenesis via an Endothelial Nitric Oxide Synthase-Dependent Mechanism

Hayashida

Kondo

Morita

et al. 2017

Circ J

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Background: Hydrogen sulfide (H2S) exerts beneficial actions against the development of cardiovascular disease. Diallyl trisulfide (DATS) is an organic polysulfide found in garlic oil that liberates H2S under physiological conditions. This study investigated whether DATS modulates endothelial cell function, as well as revascularization processes in a mouse model of hind-limb ischemia. Methods and Results:Wild-type (WT), endothelial nitric oxide synthase-deficient (eNOS-KO) and Akt1-heterogenic deficient (AktHet) mice were subjected to unilateral hindlimb ischemia (HLI). DATS or a vehicle control was injected into the abdomen of mice for up to 10 days following HLI induction. Treatment with DATS enhanced blood flow recovery and capillary density in the ischemic limbs of WT mice. This was accompanied by a reduction in apoptotic activity and oxidative stress in the ischemic muscles. DATS also increased the phosphorylation of Akt and eNOS in ischemic muscles. In contrast to WT mice, DATS did not improve blood flow of eNOS-KO and Akt-Het mice. In cultured human umbilical vein endothelium cells, DATS decreased apoptotic activity and oxidative stress under hypoxic conditions, and stimulated the phosphorylation of Akt and eNOS. Inhibition of Akt or NOS signaling reversed DATS-stimulated eNOS phosphorylation and blocked the effects of DATS on apoptosis and oxidative stress. Conclusions:These observations suggest that DATS promotes revascularization in response to HLI through its ability to stimulate the Akt-eNOS signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Diallyl Trisulfide Augments Ischemia-Induced Angiogenesis via an Endothelial Nitric Oxide Synthase-Dependent Mechanism

Hayashida

Kondo

Morita

et al. 2017

Circ J

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“…Collagen Synthesis and Extracellular Accumulation-Synthesis and extracellular accumulation of intact collagen was measured using the method described by Zhang et al (24), with slight modifications. Cells were grown to ϳ80% confluency, washed twice with serum-free medium, and incubated for 0 -30 h in serum-free medium containing 2 mCi/ml L- [2,3,4,5-3 H (N)]proline (Perkin Elmer).…”

Section: Methodsmentioning

confidence: 99%

Insulin-like Growth Factor-1 Increases Synthesis of Collagen Type I via Induction of the mRNA-binding Protein LARP6 Expression and Binding to the 5′ Stem-loop of COL1a1 and COL1a2 mRNA

Blackstock

Higashi

Sukhanov

et al. 2014

Journal of Biological Chemistry

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Background:The la ribonucleoprotein domain family member 6, LARP6, regulates collagen type 1 mRNA translation. Results: IGF-1 increases LARP6 expression, resulting in increased LARP6-collagen type 1 mRNA complex and collagen synthesis in smooth muscle. Conclusion: IGF-1 enhances collagen fibrillogenesis via induction of LARP6. Significance: This report uncovers a critical mechanism whereby IGF-1 induces a more stable plaque phenotype in atherosclerosis.

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“…Interestingly, H 2 S has a direct inhibitory effect on angiotensin-converting enzyme (ACE) activity, which catalyzes the conversion of angiotensin I into angiotensin II (62). Moreover, H 2 S can decrease angiotensin II-induced mitogen-activated protein kinase (MAPK) activation, AT1 receptor binding, and the binding affinity of AT1 receptor in a dose-dependent manner (63). In addition, Lu et al demonstrated that H 2 S inhibits renin activity, which participates in the renin-angiotensin system (64).…”

Section: Role Of H 2 S In Regulation Of Agingmentioning

confidence: 99%

Hydrogen Sulfide, the Next Potent Preventive and Therapeutic Agent in Aging and Age-Associated Diseases

Zhang

Tang

Zhong

et al. 2013

Molecular and Cellular Biology

154

109

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Hydrogen sulfide (H 2 S) is the third endogenous signaling gasotransmitter, following nitric oxide and carbon monoxide. It is physiologically generated by cystathionine-␥-lyase, cystathionine-␤-synthase, and 3-mercaptopyruvate sulfurtransferase. H 2 S has been gaining increasing attention as an important endogenous signaling molecule because of its significant effects on the cardiovascular and nervous systems. Substantial evidence shows that H 2 S is involved in aging by inhibiting free-radical reactions, activating SIRT1, and probably interacting with the age-related gene Klotho. Moreover, H 2 S has been shown to have therapeutic potential in age-associated diseases. This article provides an overview of the physiological functions and effects of H 2 S in aging and age-associated diseases, and proposes the potential health and therapeutic benefits of H 2 S.

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Regulatory Effect of Hydrogen Sulfide on Vascular Collagen Content in Spontaneously Hypertensive Rats

Abstract: The present study aimed to examine the regulatory effect of hydrogen sulfide (H2S) on vascular collagen remodeling in hypertensive rats. After 5 weeks of H2S donor treatment, tail blood pressure, the endogenous

Cited by 99 publications

References 35 publications

Diallyl Trisulfide Augments Ischemia-Induced Angiogenesis via an Endothelial Nitric Oxide Synthase-Dependent Mechanism

Diallyl Trisulfide Augments Ischemia-Induced Angiogenesis via an Endothelial Nitric Oxide Synthase-Dependent Mechanism

Insulin-like Growth Factor-1 Increases Synthesis of Collagen Type I via Induction of the mRNA-binding Protein LARP6 Expression and Binding to the 5′ Stem-loop of COL1a1 and COL1a2 mRNA

Hydrogen Sulfide, the Next Potent Preventive and Therapeutic Agent in Aging and Age-Associated Diseases

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