Regulatory Effect of Ellagic Acid on Immune Function in Burned Rats

Deng, Hong-ao; Chen, Yong; Yuan, Yuan; Zhang, H.

doi:10.1093/jbcr/irad041

Cited by 1 publication

(1 citation statement)

References 27 publications

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“…In an in vivo study of rats conducted by Deng et al, the treatment of skin burns with ellagic acid (at 50 or 100 mg/kg) was found to significantly reduce serum concentrations of IgA, IgG, IgM, TNF-α, IFN-γ, IL-1β, IL-6, and IL-10, while significantly increasing CD4+/CD8+ T cell and CD4+ CD25+ Treg cell counts, and decreasing the Foxp3 + T cell count. These changes suggest an anti-inflammatory effect and improvements in the immune system [ 53 ]. BenSaad et al [ 51 ] attributed the anti-inflammatory effects of ellagic acid, gallic acid, and punicalagin on liposaccharide-treated RAW267.4 cells to the capacity of these polyphenols to inhibit nitric oxide, prostaglandin E2, and IL-6 production.…”

Section: Discussionmentioning

confidence: 99%

Effect of Punicalagin and Ellagic Acid on Human Fibroblasts In Vitro: A Preliminary Evaluation of Their Therapeutic Potential

Illescas-Montes,

Rueda-Fernández,

González-Acedo

et al. 2023

Nutrients

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Background: Pomegranate is a fruit that contains various phenolic compounds, including punicalagin and ellagic acid, which have been attributed to anti-inflammatory, antioxidant, and anticarcinogenic properties, among others. Objective: To evaluate the effect of punicalagin and ellagic acid on the viability, migration, cell cycle, and antigenic profile of cultured human fibroblasts (CCD-1064Sk). MTT spectrophotometry was carried out to determine cell viability, cell culture inserts were used for migration trials, and flow cytometry was performed for antigenic profile and cell cycle analyses. Cells were treated with each phenolic compound for 24 h at doses of 10−5 to 10−9 M. Results: Cell viability was always significantly higher in treated versus control cells except for punicalagin at 10−9 M. Doses of punicalagin and ellagic acid in subsequent assays were 10−6 M or 10−7 M, which increased the cell migration capacity and upregulated fibronectin and α-actin expression without altering the cell cycle. Conclusions: These in vitro findings indicate that punicalagin and ellagic acid promote fibroblast functions that are involved in epithelial tissue healing.

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Section: Discussionmentioning

confidence: 99%