Regulatory CD4+CD25+ T lymphocytes in peripheral blood from patients with atopic asthma

Shi, Huan‐Zhong; Li, Shan; Xie, Zijian; Qin, Xuejun; Qin, Xue; Zhong, Xiaoning

doi:10.1016/j.clim.2004.06.009

Cited by 73 publications

(68 citation statements)

References 32 publications

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“…37 A recent study demonstrated that periphery CD4 ϩ CD25 ϩ Treg cells are lower in asthmatic patients than that in control individuals. 38 In this study, we have found that hemin directly upregulated HO-1 in CD4 ϩ CD25 ϩ Treg cells in a cell culture system. Consequently, foxp3 expression and Treg activity were enhanced.…”

Section: Discussionmentioning

confidence: 84%

Heme Oxygenase-1 Attenuates Ovalbumin-Induced Airway Inflammation by Up-Regulation of Foxp3 T-Regulatory Cells, Interleukin-10, and Membrane-Bound Transforming Growth Factor-β1

Xia

Zhong

et al. 2007

The American Journal of Pathology

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Asthma is an airway disease characterized by recurrent inflammation. It occurs in all age groups and is ranked as one of the most prevalent noninfectious diseases. It is estimated that 160 million people worldwide suffer with asthma. Despite 20 years of effort, the morbidity and mortality rates of asthma have been rising all throughout the world. As a result, our society bears significant health and economic burdens for the disease. Therefore, it is imperative to understand fully the pathogenesis of asthma and develop novel preventive/therapeutic strategy. Heme oxygenase (HO) is a rate-limiting enzyme for heme metabolism. It catalyzes heme into equivalent amounts of biliverdin, carbon monoxide (CO), and free iron. At present, there are three known isoenzymes of HO: inducible HO-1, constitutive HO-2, and a newly found isomer HO-3.

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Section: Discussionmentioning

confidence: 84%

Heme Oxygenase-1 Attenuates Ovalbumin-Induced Airway Inflammation by Up-Regulation of Foxp3 T-Regulatory Cells, Interleukin-10, and Membrane-Bound Transforming Growth Factor-β1

Xia

Zhong

et al. 2007

The American Journal of Pathology

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“…Treg may block the transition from the early activation stage to the differentiated T helper 2 (Th2) state, limit airway allergic inflammation and act to prevent inappropriate Th2 responses to environmental allergens [15,16]. Several independent lines of evidence indicate that the number or function of Treg is impaired or altered in patients with allergies compared with healthy individuals [17][18][19][20][21][22]. However, data concerning the role of Treg in the pathogenesis of paediatric allergic disease are rare.…”

Section: Cd25mentioning

confidence: 99%

The levels of CD4+CD25+ regulatory T cells in paediatric patients with allergic rhinitis and bronchial asthma

Lee

Wang

et al. 2007

Clinical and Experimental Immunology

168

109

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SummaryOur purpose was to determine whether numbers of CD4 + CD25 + T [T regulatory (Treg)] cells and mRNA expression of functional molecules of Treg are related to airway allergy and disease severity in 51 paediatric patients with allergic rhinitis or bronchial asthma and 47 healthy controls. Surface markers were evaluated with flow cytometry, and mRNA was determined with realtime polymerase chain reaction. Children with allergic disease had fewer CD4 + CD25 + T cells (8·49% Ϯ 2·41% versus 9·58% Ϯ 2·43%, P < 0·05) and CD4 + CD25 hi T cells (1·32% Ϯ 0·68% versus 1·70% Ϯ 0·68%, P < 0·01) than control subjects. Numbers of CD4 + CD25 + and CD4 + CD25 hi T lymphocytes were higher in children with persistent allergic rhinitis and/or moderatesevere bronchial asthma than in those with respective milder disease. The number of Treg cells was correlated positively with total immunoglobulin E level. The mRNA expression of forkhead box P3 (FoxP3) was increased in moderate-severe versus mild asthma (2·93 Ϯ 0·38 versus 1·60 Ϯ 0·31, P < 0·01). Patients with moderate-severe bronchial asthma also had increased mRNA expression of interleukin (IL)-10 compared with patients with mild asthma (15·24 Ϯ 4·07 versus 3·77 Ϯ 2·18, P < 0·01). The suppressive function of Treg cells from patients with more severe asthma was competent in vitro. On average, decreased numbers of Treg cells in children with allergic airway disease might represent a defect of the Treg population. With increased expression of FoxP3 and IL-10 in Treg from patients with relatively severe allergic disease, adaptive and functional Treg might be generated in response to aggravated atopy and disease severity.

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“…Several studies show that there is functional impairment of Tregs in asthmatic patients (90)(91)(92)95). In the Hartl study (90), both blood and pulmonary cells from nonasthmatic children were competent to suppress CD4+CD25) T-cell proliferative, cytokine and chemokine responses.…”

Section: Treg Function In Asthma and The Effects Of Therapeutic Intermentioning

confidence: 99%

“…The level of Foxp3 protein was not evaluated in these studies but one might assume that it would be decreased in line with the other findings. Shi (95) identified a higher proportion of regulatory T cells in stable and unstable asthmatics, but the study only measured the total CD25+ population, so this population may have included effector cells. Additional studies noted increased numbers of CD25 high cells in the peripheral blood of allergic asthma patients despite the lower expression of Foxp3 in comparison with nonatopic control subjects (92) or no significant difference in Treg numbers, based on CD4+CD25+ phenotype, between atopic asthmatic vs and nonatopic subjects (94).…”

Section: Studies Of Treg In Human Bronchial Asthmamentioning

confidence: 99%

“…Studies of Tregs in bronchial asthma, as opposed to allergy are much more limited, but there is evidence to suggest that they are associated with the disease in both paediatric (89)(90)(91)(92) and adult (93)(94)(95)(96)(97) patients. Probably, the most convincing evidence for a role of Foxp3+ Treg in preventing the development of atopic disease stems from studies of the X-linked autoimmunity-allergic dysregulation syndrome, also termed immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome.…”

Section: Studies Of Treg In Human Bronchial Asthmamentioning

confidence: 99%

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Regulatory T cells in bronchial asthma

Ryanna¹,

Stratigou²,

Safinia

et al. 2009

Allergy

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The main focus of this review was the role of a specific subset of T cells with immunomodulatory or immunosuppressive activities, termed regulatory T cells (Tregs), in the pathogenesis and treatment of bronchial asthma. Evidence that these cells are important in maintaining immune homeostasis in health and exhibit impaired activity in active disease will be discussed. Their therapeutic potential is perhaps best highlighted by evidence that therapies with demonstrated efficacy in allergic and asthmatic disease are associated with the induction or restoration of regulatory T‐cell function, e.g. glucocorticoids, allergen immunotherapy. Strategies to improve the safety and efficacy of these treatments and that induce or boost Tregs in bronchial asthma are discussed.

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Regulatory CD4+CD25+ T lymphocytes in peripheral blood from patients with atopic asthma

Cited by 73 publications

References 32 publications

Heme Oxygenase-1 Attenuates Ovalbumin-Induced Airway Inflammation by Up-Regulation of Foxp3 T-Regulatory Cells, Interleukin-10, and Membrane-Bound Transforming Growth Factor-β1

Heme Oxygenase-1 Attenuates Ovalbumin-Induced Airway Inflammation by Up-Regulation of Foxp3 T-Regulatory Cells, Interleukin-10, and Membrane-Bound Transforming Growth Factor-β1

The levels of CD4+CD25+ regulatory T cells in paediatric patients with allergic rhinitis and bronchial asthma

Regulatory T cells in bronchial asthma

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