Regulatory B lymphocytes in humans: A potential role in autoimmunity

Jamin, Christophe; Morva, Ahsen; Lemoine, Sébastien; Daridon, Capucine; Mendoza, Agnés Revol de; Youinou, Pierre

doi:10.1002/art.23487

Cited by 53 publications

(28 citation statements)

References 48 publications

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“…This fact underscores the caution that must be exercised when using B-cell depletion therapies for the long-term treatment of autoimmune disorders, because they might deplete not only pathogenic but also regulatory B cells. However, the existence of a human counterpart of Breg cells remains a matter of debate and continued study (Jamin et al, 2008). It is noteworthy that one recent report described a subset of human regulatory B cells that was enriched within a CD19…”

Section: E Regulatory B Cellsmentioning

confidence: 99%

Therapeutic Targeting of B Cells for Rheumatic Autoimmune Diseases

et al. 2011

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Section: E Regulatory B Cellsmentioning

confidence: 99%

Therapeutic Targeting of B Cells for Rheumatic Autoimmune Diseases

et al. 2011

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“…Recent works have suggested that human B cells can also regulate inflammatory responses [22]. Thus, B cell depletion therapies have been reported to exacerbate ulcerative colitis [23], or lead to the development of psoriasis in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients [24].…”

Section: Introductionmentioning

confidence: 99%

Human T cells induce their own regulation through activation of B cells

Lemoine

Morva

Youinou

et al. 2011

Journal of Autoimmunity

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135

115

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“…MZB express MHC II and B7.1 constitutively, allowing them to present antigen efficiently to T cells [30]. MZB can secrete IL-10 and act as regulatory B cells, thus inhibiting rather than stimulating various T cell responses [31]. Alternatively, MZB can serve to focus the T cell response to particular pathogens to restricted locations.…”

Section: Discussionmentioning

confidence: 99%

Central role for marginal zone B cells in an animal model of Sjogren's syndrome

Shen

Gao

Suresh

et al. 2016

Clinical Immunology

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Patients with Sjogren’s syndrome (SS) have been shown to have abnormal B cell function and increased numbers of marginal zone B cells (MZB and MZB precursors. The current studies utilized the Interleukin 14 alpha transgenic mouse model (IL14aTG) for SS to investigate the roles of marginal zone B cells (MZB) of the innate immune system in the pathophysiology of the disease. Eliminating MZB from IL14aTG mice by B cell specific deletion of RBP-J resulted in complete elimination of all disease manifestations of SS. Mice had normal salivary gland secretions, negative autoantibodies and normal histology of the salivary and lacrimal glands compared to IL14aTG mice at the same time points. In contrast, eliminating B1 cells by deleting btk did not ameliorate the disease. Therefore, MZB are critical for the development of SS.

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Regulatory B lymphocytes in humans: A potential role in autoimmunity

Cited by 53 publications

References 48 publications

Therapeutic Targeting of B Cells for Rheumatic Autoimmune Diseases

Therapeutic Targeting of B Cells for Rheumatic Autoimmune Diseases

Human T cells induce their own regulation through activation of B cells

Central role for marginal zone B cells in an animal model of Sjogren's syndrome

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