Regulatory B Lymphocytes Colonize the Respiratory Tract of Neonatal Mice and Modulate Immune Responses of Alveolar Macrophages to RSV Infection in IL-10-Dependant Manner

Laubreton, Daphné; Drajac, Carole; Éléouët, Jean-François; Rameix‐Welti, Marie‐Anne; Lo‐Man, Richard; Riffault, Sabine; Descamps, Delphyne

doi:10.3390/v12080822

Cited by 13 publications

(15 citation statements)

References 48 publications

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“…These Bregs are also not present in the adult lung, highlighting the importance of studying early-life immunity. A neonatal BALB/c mouse model of RSV-infection showed that Bregs colonise the lungs in the first week of life and can affect the overall respiratory immune environment [ 75 ]. These neonatal Bregs dampened the release of IFN-γ in response to RSV infection in an IL-10-dependent manner, resulting in a failure to contain RSV replication.…”

Section: Resultsmentioning

confidence: 99%

“…This has been corroborated in human studies, where it was shown that these nBregs can be infected with human RSV (hRSV), and subsequently dampen the Type-1 immune response, promoting a biased Type-2 response and worsening disease outcomes [ 27 , 76 ]. An alternative method that has been proposed for nBregs to worsen RSV-associated pathogenesis is through the suppression of AMφ antiviral function [ 75 ]. The IL-10 produced by nBregs can suppress the secretion of IFN-α and -β ex vivo, influencing the AMφs towards a Type-17-like phenotype instead.…”

Section: Resultsmentioning

confidence: 99%

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Mucosal Immune Responses to Respiratory Syncytial Virus

Barnes

Openshaw

Thwaites

2022

Cells

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Despite over half a century of research, respiratory syncytial virus (RSV)-induced bronchiolitis remains a major cause of hospitalisation in infancy, while vaccines and specific therapies still await development. Our understanding of mucosal immune responses to RSV continues to evolve, but recent studies again highlight the role of Type-2 immune responses in RSV disease and hint at the possibility that it dampens Type-1 antiviral immunity. Other immunoregulatory pathways implicated in RSV disease highlight the importance of focussing on localised mucosal responses in the respiratory mucosa, as befits a virus that is essentially confined to the ciliated respiratory epithelium. In this review, we discuss studies of mucosal immune cell infiltration and production of inflammatory mediators in RSV bronchiolitis and relate these studies to observations from peripheral blood. We also discuss the advantages and limitations of studying the nasal mucosa in a disease that is most severe in the lower airway. A fresh focus on studies of RSV pathogenesis in the airway mucosa is set to revolutionise our understanding of this common and important infection.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Mucosal Immune Responses to Respiratory Syncytial Virus

Barnes

Openshaw

Thwaites

2022

Cells

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“…115 RSV model Breg cells produced IL−10 and reduce the expression of type-I interferon. 117 HIV patients have higher Breg frequencies. 116…”

Section: Viral Infectionsmentioning

confidence: 93%

“…After RSV infection, Breg cells produced IL-10 that can reduce the expression of type-I interferon secretion and thereby possibly reduce antiviral responses. 117 Besides viruses, bacterial infections can also trigger the induction of Breg cells. Helicobacter pylori infection is associated with an increased number of IL-10 + B cells.…”

Section: B Reg Cell Re S P On S E S During Infec Tionsmentioning

confidence: 99%

Regulatory B cells, A to Z

Jansen

Cevhertas

et al. 2021

Allergy

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B cells play a central role in the immune system through the production of antibodies. During the past two decades, it has become increasingly clear that B cells also have the capacity to regulate immune responses through mechanisms that extend beyond antibody production. Several types of human and murine regulatory B cells have been reported that suppress inflammatory responses in autoimmune disease, allergy, infection, transplantation, and cancer. Key suppressive molecules associated with regulatory B-cell function include the cytokines IL-10, IL-35, and TGFβ as well as cell membrane-bound molecules such as programmed death-ligand 1, CD39, CD73, and aryl hydrocarbon receptor. Regulatory B cells can be induced by a range of different stimuli, including microbial products such as TLR4 or TLR9 ligands, inflammatory cytokines such as IL-6, IL-1β, and IFNα, as well as CD40 ligation. This review provides an overview of our current knowledge on regulatory B cells. We discuss different types of regulatory B cells, the mechanisms through which they exert their regulatory functions, factors that lead to induction of regulatory B cells and their role in the alteration of inflammatory responses in different diseases.

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“…RSV particles bind and infect fetal Breg in lung tissues, inducing the upregulation of Breg CX3CR1 chemokine receptors that interact with RSV G glycoproteins to stimulate IL-10 secretion and downstream anti-inflammatory responses. 278,279 Profuse IL-10 release has been correlated with diminished T helper 1 (Th1) priming or activation. In conjunction with increased RSV-infected Breg cell frequencies, IL-10 elevations may be predictive for more severe outcomes in the setting of RSV infections during pregnancy.…”

Section: Pregnancyinfluencesonbcellresponsesto Viral Infectionsmentioning

confidence: 99%

Role of hormones in the pregnancy and sex‐specific outcomes to infections with respiratory viruses*

Cervantes

Talavera

Every

et al. 2022

Immunological Reviews

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Pregnant women infected with pathogenic respiratory viruses, such as influenza A viruses (IAV) and coronaviruses, are at higher risk for mortality, hospitalization, preterm birth, and stillbirth. Several factors are likely to contribute to the susceptibility of pregnant individuals to severe lung disease including changes in pulmonary physiology, immune defenses, and effector functions of some immune cells. Pregnancy is also a physiologic state characterized by higher levels of multiple hormones that may impact the effector functions of immune cells, such as progesterone, estrogen, human chorionic gonadotropin, prolactin, and relaxin. Each of these hormones acts to support a tolerogenic immune state of pregnancy, which helps prevent fetal rejection, but may also contribute to an impaired antiviral response. In this review, we address the unique role of adaptive and innate immune cells in the control of pathogenic respiratory viruses and how pregnancy and specific hormones can impact their effector actions. We highlight viruses with sex‐specific differences in infection outcomes and why pregnancy hormones may contribute to fetal protection but aid the virus at the expense of the mother's health.

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Regulatory B Lymphocytes Colonize the Respiratory Tract of Neonatal Mice and Modulate Immune Responses of Alveolar Macrophages to RSV Infection in IL-10-Dependant Manner

Cited by 13 publications

References 48 publications

Mucosal Immune Responses to Respiratory Syncytial Virus

Mucosal Immune Responses to Respiratory Syncytial Virus

Regulatory B cells, A to Z

Role of hormones in the pregnancy and sex‐specific outcomes to infections with respiratory viruses*

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