Regulatory B Cell Function Is Suppressed by Smoking and Obesity in H. pylori-Infected Subjects and Is Correlated with Elevated Risk of Gastric Cancer

Li, Guanggang; Wulan, Hasi; Song, Zigen; Paik, Paul A.; Tsao, Ming L.; Goodman, Gary M.; MacEachern, Paul T.; Downey, Robert S.; Jankowska, Anna; Rabinowitz, Yaron M; Learch, Thomas B.; Song, David; Yuan, Ji; Zheng, Shihang; Zheng, Zhendong

doi:10.1371/journal.pone.0134591

Cited by 19 publications

(15 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We further demonstrated that the frequency of IL10 + B cells was also significantly lower in DM patients than in healthy controls (1.139 ± 0.156% vs 2.372 ± 0.205%, p < 0.001), which is consistent with previous reports describing a similar trend in the CD19 + CD24 high CD38 high Bregs and IL-10 + B cells of patients with other diseases 25 26 .…”

Section: Discussionsupporting

confidence: 92%

Significant decrease in peripheral regulatory B cells is an immunopathogenic feature of dermatomyositis

Tian

Lü

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Regulatory B cells (Bregs) are critical in maintaining self-tolerance. Their role in dermatomyositis (DM), an autoimmune disease characterized by inappropriate regulation of hyperactivated B and T cells, has not been clearly defined. In the current study, we performed flow cytometry analysis of studied CD19+ CD24highCD38high Breg subpopulations in blood samples from 30 patients with DM, 37 diseased controls and 23 healthy controls. A significant decrease was observed in the frequency of Bregs in DM patients compared to that in diseased controls (p < 0.0001) and in healthy controls (p < 0.0001). And the prevalence of Bregs deficiency (defined as Bregs/B cells < 0.50% in this study) in DM patients went as high as 73.3%. Furthermore, DM patients with positive myositis specific autoantibody often had lower Bregs levels than negative patients (p = 0.036), and lower level of Bregs was also found in DM patients with interstitial lung disease than in DM patients without (p = 0.041). In a follow-up study, seven DM patients were considered to be in remission stage, and their Breg levels were found to have significantly increased after treatment (p = 0.022). Our research revealed that Breg deficiency is an immunopathogenic feature of DM and provided insights into the design of new immunotherapy target for DM clinical interventions.

show abstract

Section: Discussionsupporting

confidence: 92%

Significant decrease in peripheral regulatory B cells is an immunopathogenic feature of dermatomyositis

Tian

Lü

et al. 2016

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In our study, a significant inverse association of high dietary flavonols intake with a reduced risk of EC and GC was observed in smokers (OR = 0.81, 95% CI: 0.71–0.91) but not in nonsmokers (OR = 1.07, 95% CI: 0.91–1.25). Tobacco smoking can cause oxidative stress, and both oxidative stress and smoking tobacco are related to an increased risk of EC and GC [ 41 , 42 ]. The possible chemopreventive mechanism of dietary flavonols may be attributed to their anti-oxidant properties, not only direct anti-oxidant action, but more importantly the ability to modulate related enzymatic pathways.…”

Section: Discussionmentioning

confidence: 99%

Dietary Flavonols Intake and Risk of Esophageal and Gastric Cancer: A Meta-Analysis of Epidemiological Studies

Xie

Huang

2016

Nutrients

View full text Add to dashboard Cite

Background: Esophageal cancer (EC) and gastric cancer (GC) are common cancers and leading causes of cancer deaths worldwide. Many studies have investigated the association between dietary flavonols intake and the risk of EC and GC, but the results are inconsistent. Hence, we conducted a systematic analysis of relevant population-based studies to assess the association and derive a more precise estimation. Methods: The Cochrane, PubMed and Embase databases were searched to identify articles published through January 2016 that met the predetermined inclusion criterion. Twelve studies involving 4593 patients and 519,378 controls were included. Results: The summary odds ratios (ORs) of EC, GC and the two combined were respectively 0.88 (95% CI: 0.73–1.08), 0.80 (95% CI: 0.70–0.91) and 0.83 (95% CI: 0.74–0.92) for the highest category of dietary flavonols intake compared with the lowest. No significant heterogeneities were observed in these studies. Further analysis showed that the pooled ORs of EC and GC for cohort, population-based case-control and hospital-based case-control studies were 0.90 (95% CI: 0.61–1.34), 0.92 (95% CI: 0.72–1.18), 0.68 (95% CI: 0.38–1.24) and 0.83 (95% CI: 0.65–1.06), 0.84 (95% CI: 0.45–1.59), 0.70 (95% CI: 0.56–0.88). The subgroup analyses revealed a significant association of flavonol intake with a reduced risk of noncardia gastric adenocarcinoma but not gastric cardia adenocarcinoma. Moreover, significant inverse associations of flavonol intake with GC risk were observed in women but not in men, in smokers but not in nonsmokers, in European populations but not in American populations. Similarly, a significant inverse association of flavonols intake with EC risk was also observed in smokers but not in nonsmokers. Conclusion: High intake of dietary flavonols is significantly related to a reduced risk of GC, especially in women and smokers.

show abstract

“…Smoking is a contributing factor of the carcinogenesis of gastric cancer [ 31 , 35 ]. Recently it has been reported that smoking suppresses regulatory B cell and inhibits the production of interleukin 10; both events may increase the risk of gastric cancer [ 36 ]. Our results suggest that increased DUOX2 expression may contribute to the smoking-induced tumorigenesis of gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

DUOX2 Expression Is Increased in Barrett Esophagus and Cancerous Tissues of Stomach and Colon

Zhou

et al. 2016

Gastroenterology Research and Practice

View full text Add to dashboard Cite

Aim. To detect the expression of dual oxidase (DUOX) 2 in Barrett esophagus, gastric cancer, and colorectal cancer (CRC). Materials and Methods. The endoscopic biopsies were collected from patients with Barrett esophagus, while the curative resection tissues were obtained from patients with gastric cancer, CRC, or hepatic carcinoma. The DUOX2 protein and mRNA levels were detected with immunohistochemistry (IHC) and real-time quantitative PCR (qPCR). The correlation of DUOX2 expression with clinicopathological parameters of tumors was identified. Results. Low levels of DUOX2 mRNA were detected in Barrett esophagus and the adjacent normal tissues, and there was no difference between these two groups. DUOX2 protein was found in Barrett esophagus and undetectable in the normal epithelium. The DUOX2 mRNA and protein levels in the gastric cancer and CRC were increased compared to the adjacent nonmalignant tissues. The elevated DUOX2 in the gastric cancer was significantly associated with smoking history. In CRC tissues, the DUOX2 protein expression level in stages II–IV was significantly higher than that in stage I. In both hepatic carcinoma and the adjacent nonmalignant tissue, the DUOX2 was virtually undetectable. Conclusion. DUOX2 in Barrett esophagus, gastric cancer, and CRC may be involved in the tumorigenesis of these tissues.

show abstract

Regulatory B Cell Function Is Suppressed by Smoking and Obesity in H. pylori-Infected Subjects and Is Correlated with Elevated Risk of Gastric Cancer

Cited by 19 publications

References 33 publications

Significant decrease in peripheral regulatory B cells is an immunopathogenic feature of dermatomyositis

Significant decrease in peripheral regulatory B cells is an immunopathogenic feature of dermatomyositis

Dietary Flavonols Intake and Risk of Esophageal and Gastric Cancer: A Meta-Analysis of Epidemiological Studies

DUOX2 Expression Is Increased in Barrett Esophagus and Cancerous Tissues of Stomach and Colon

Contact Info

Product

Resources

About