Regulatory and Sensing Iron–Sulfur Clusters: New Insights and Unanswered Questions
Anna M. SantaMaria,
Tracey A. Rouault
Abstract:Iron is an essential nutrient and necessary for biological functions from DNA replication and repair to transcriptional regulation, mitochondrial respiration, electron transfer, oxygen transport, photosynthesis, enzymatic catalysis, and nitrogen fixation. However, due to iron’s propensity to generate toxic radicals which can cause damage to DNA, proteins, and lipids, multiple processes regulate the uptake and distribution of iron in living systems. Understanding how intracellular iron metabolism is optimized a… Show more
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