Regulatory and Communication Shifts in Dilated Cardiomyopathy: A Multimodal Single-Cell Analysis
Yangfeng Tang#,
Jiajun Zhang#,
Xiangyang Xu#
et al.
Abstract:Dilated cardiomyopathy (DCM), a major cause of heart failure in young adults, is characterized by ventricular dilation and progressive heart muscle dysfunction. Cellular mechanisms driving DCM have not been elucidated despite advances in genomic medicine. This study performed comprehensive multimodal single-cell analysis integrating RNA sequencing, assay for transposase-accessible chromatin with sequencing, and spatial transcriptomics data of cardiac tissues from patients with DCM and control subjects. The com… Show more
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