Regulators CDCA8 as potential targets and biomarkers for the prognosis of human skin cutaneous melanoma

Abstract

Cutaneous melanoma (CM) is considered as the most malignant skin tumor with high distant metastasis and poor prognosis. Cell division cycle-associated protein (CDCA) family has a role in regulating cell proliferation and modulating immune cell and tumor cell proliferation in the tumor microenvironment to regulate tumor oncogenesis, development and affect patient outcomes. However, the differential expression pattern and prognostic value of CDCA factors (CDCAs) have not been clarified. In this study, the role of CDCAs in CM was analyzed by using bioinformatics and found that the transcriptional expressions of CDCA1/2/3/5/6/8 were upregulating in CM samples than in normal compares. CM patients with downregulated of CDCA1/3/4/5/6/8 and high transcriptional levels of CDCA7 suggest a significantly better prognosis.Furthermore, the significant correlations among the expression of CDCAs and the infiltration of immune cells. In terms of the protein level, we found CDCA8 was upregulated in CM patients. In conclusion, CDCA8 is a powerful prognostic biomarker for CM and can be a novel target for immunotherapy.

Effect of Sun exposure-induced ferroptosis mechanisms on pathology and potential biological processes of primary melanoma by microarray data analysis

“…Growing evidence suggests that tumor immune microenvironment is an important factor affecting tumor progression, and tumor immunotherapy is expected to be an effective means to delay tumor progression (Liu et al, 2017;Guo et al, 2022). Therefore, we explored the enrichment status of Frontiers in Genetics frontiersin.org 13 immune cells in melanoma samples, and showed that melanoma samples had higher levels of infiltration of memory resting CD4 + T cells, helper follicular T cells, activated dendritic cells and resting mast cells, and had lower levels of infiltration of native B cells, native CD4 + T cells, resting NK cells, resting dendritic cells and activated mast cells (Figure 7E).…”

“…Skin cutaneous melanoma (SKCM) is the most common malignant tumor of skin cancer with the highest mortality rate. It originates from melanocytes and is highly malignant and prone to metastasis ( Guo et al, 2022 ). Melanocytes produce and release melanin, which acts as a barrier to ultraviolet (UV) radiation, thus preventing UV-induced DNA mutations.…”