Regulators of Ovarian Preantral Follicle Development

McGee, Elizabeth A.; Raj, Renju S.

doi:10.1055/s-0035-1552584

Cited by 22 publications

(6 citation statements)

References 15 publications

(28 reference statements)

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“…Follicle activation is a critical step of early folliculogenesis, which involves dramatic changes in both structure and function ( 1 , 72 ). A large body of evidence has accumulated in recent years in both mammals and fish that follicle activation or recruitment involves extensive regulation by endocrine and paracrine factors ( 20 , 73 , 74 ), which activate a variety of signaling pathways ( 75 ).…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic Analysis for Differentially Expressed Genes in Ovarian Follicle Activation in the Zebrafish

et al. 2018

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In teleosts, the onset of puberty in females is marked by the appearance of the first wave of pre-vitellogenic (PV) follicles from the pool of primary growth (PG) follicles (follicle activation) in the ovary during sexual maturation. To understand the mechanisms underlying follicle activation and therefore puberty onset, we undertook this transcriptomic study to investigate gene expression profiles in the event. Our analysis revealed a total of 2,027 up-regulated and 859 down-regulated genes during the PG-PV transition. Gene Ontology (GO) analysis showed that in addition to basic cellular functions such as gene transcription, cell differentiation, and cell migration, other biological processes such as steroidogenesis, cell signaling and angiogenesis were also enriched in up-regulated genes; by comparison, some processes were down-regulated including piRNA metabolism, gene silencing and proteolysis. Further Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis identified a variety of signaling pathways that might play pivotal roles in PG-PV transition, including MAPK, TGF-β, Hedgehog, FoxO, VEGF, Jak-STAT, and phosphatidylinositol signaling pathways. Other pathways of particular interest included endocytosis and glycosaminoglycan biosynthesis. We also analyzed expression changes of genes expressed in different compartments viz. oocytes and follicle cells. Interestingly, most oocyte-specific genes remained unchanged in expression during follicle activation whereas a great number of genes specifically expressed in the follicle cells showed significant changes in expression. Overall, this study reported a comprehensive analysis for genes, biological processes and pathways involved in follicle activation, which also marks female puberty onset in the zebrafish when occurring for the first time in sexual maturation.

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Section: Discussionmentioning

confidence: 99%

Transcriptomic Analysis for Differentially Expressed Genes in Ovarian Follicle Activation in the Zebrafish

et al. 2018

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“…The maturation phase begins after puberty when primary oocytes re-enter meiosis I and become secondary oocytes. Oocyte maturation occurs simultaneously with folliculogenesis under the influence of hormonal regulation [ 14 ]. Secondary oocytes are arrested in metaphase of meiosis II and are then considered mature oocytes which will either be ovulated or undergo atresia (degeneration).…”

Section: The Reproductive Processmentioning

confidence: 99%

The Role of the Epididymis and the Contribution of Epididymosomes to Mammalian Reproduction

James

Carrell

Aston

et al. 2020

IJMS

170

103

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It is well-established that testicular spermatozoa are immature and acquire motility and fertilization capabilities during transit throughout the epididymis. The epididymis is a duct-like organ that connects the testis to the vas deferens and is comprised of four anatomical regions: the initial segment, caput, corpus, and cauda. Sperm maturation occurs during epididymal transit by the interaction of sperm cells with the unique luminal environment of each epididymal region. In this review we discuss the epididymis as an essential reproductive organ responsible for sperm concentration, maturation (including sperm motility acquisition and fertilizing ability), protection and storage. Importantly, we also discuss specific characteristics and roles of epididymal-derived exosomes (epididymosomes) in establishing sperm competency within the intricate process of reproduction. This review suggests that an increasing body of evidence is working to develop a complete picture of the role of the epididymis in male reproduction, offspring health, and disease susceptibility.

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“…Extensive research on follicle development has been conducted, mainly at the late antral and preovulatory stages, from those recovered in vivo as well as cultured in vitro granulosa cells. However, a better understanding of the early steps of ovarian folliculogenesis, in particular, during the preantral to early antral transition, is still needed (Palma et al 2012, McGee & Raj 2015. Research on preantral follicles is justified by the fact that they constitute a large proportion of the total follicular population in the ovarian cortex (Gougeon 1996, Scaramuzzi et al 2011, and they survive cryopreservation in sheep, goats and humans (Cecconi et al 2004, Vanacker et al 2013.…”

Section: Introductionmentioning

confidence: 99%

Molecular evidence that follicle development is accelerated in vitro compared to in vivo

Cadoret

Frapsauce²,

Jarrier

et al. 2017

Reproduction

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In this study, we systematically compared the morphological, functional and molecular characteristics of granulosa cells and oocytes obtained by a three-dimensional model of ovine ovarian follicular growth with those of follicles recovered Preantral follicles of 200 µm diameter were recovered and cultured up to 950 µm over a 20-day period. Compared with follicles, the culture conditions maintained follicle survival, with no difference in the rate of atresia. However, the conditions induced a slight decrease in oocyte growth rate, delayed antrum formation and increased granulosa cell proliferation rate, accompanied by an increase and decrease in and mRNA expression respectively. These changes were associated with advanced granulosa cell differentiation in early antral follicles larger than 400 µm diameter, regardless of the presence or absence of FSH, as indicated by an increase in estradiol secretion, together with decreased AMH secretion and expression, as well as increased expression of, ,, ,, ,, and There was a decrease in the expression of oocyte-specific molecular markers ,, , and compared to that Moreover, a higher percentage of the oocytes recovered from cultured follicles 550 to 950 µm in diameter was able to reach the metaphase II meiosis stage. Overall, this model of ovarian follicle development is characterized by accelerated follicular maturation, associated with improved developmental competence of the oocyte, compared to follicles recovered.

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Regulators of Ovarian Preantral Follicle Development

Cited by 22 publications

References 15 publications

Transcriptomic Analysis for Differentially Expressed Genes in Ovarian Follicle Activation in the Zebrafish

Transcriptomic Analysis for Differentially Expressed Genes in Ovarian Follicle Activation in the Zebrafish

The Role of the Epididymis and the Contribution of Epididymosomes to Mammalian Reproduction

Molecular evidence that follicle development is accelerated in vitro compared to in vivo

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