Regulators of mitochondrial dynamics in cancer

Senft, Daniela; Ronai, Ze’ev

doi:10.1016/j.ceb.2016.02.001

Cited by 205 publications

(233 citation statements)

References 85 publications

(74 reference statements)

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“…Imbalance towards fragmentation of the mitochondrial network is often found in several cancer cells [146]. Interestingly, the oncogenic MAPK/ERK pathway, which is a driver of cancer progression in different tumors, is able to upregulate Drp1 activity in different cancers [147,148] by phosphorylation on serine residue Ser616 [147].…”

Section: Mitochondrial Dynamics As Possible Therapeutic Targetsmentioning

confidence: 99%

The mitochondrial dynamics in cancer and immune-surveillance

Simula

Nazio

Campello

2017

Seminars in Cancer Biology

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A B S T R A C TMitochondria-shaping proteins control the dynamic equilibrium between fusion and fission of the mitochondrial network. Their balance is strictly required to regulate various processes, including the quality of mitochondria, cell metabolism, cell death, proliferation and cell migration. Alterations in these processes are frequently encountered in cancer, during both its onset and later progression, as evidence emerge connecting alterations in mitochondrial dynamics with cancer development. In recent years, novel therapeutic approaches to fight against different human tumors aim at exploiting the immune system's ability to specifically recognize tumor antigens, thus killing malignant cells in a process named immune-surveillance. Interestingly, data are accumulating on the role that mitochondrial dynamics play also for the correct function of both the innate and the adaptive immune system. By this review, we overview how mitochondrial dynamics can affect various processes during cancer development, acting directly on tumor cells or indirectly on cells responsible for tumor aggression and defence.

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Section: Mitochondrial Dynamics As Possible Therapeutic Targetsmentioning

confidence: 99%

The mitochondrial dynamics in cancer and immune-surveillance

Simula

Nazio

Campello

2017

Seminars in Cancer Biology

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“…The metabolic plasticity of cancer cells allows them to undergo dynamic changes in mitochondrial mass and mitochondrial function that facilitate their ability to cope with energy stress and oxidative stress (Senft and Ronai 2016;Vyas et al 2016). Both glycolysis and oxidative phosphorylation can be used in cancer cells in complementary strategies to enhance metabolic plasticity to overcome changes in the tumor environment or in energy demands (Jose et al 2011).…”

Section: Cancer Cells Undergo Metabolic Changes To Manage Rosmentioning

confidence: 99%

Cancer, Oxidative Stress, and Metastasis

Gill

Piskounova

Morrison

2016

Cold Spring Harb Symp Quant Biol

209

150

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Reactive oxygen species (ROS) are highly reactive molecules that arise from a number of cellular sources, including oxidative metabolism in mitochondria. At low levels they can be advantageous to cells, activating signaling pathways that promote proliferation or survival. At higher levels, ROS can damage or kill cells by oxidizing proteins, lipids, and nucleic acids. It was hypothesized that antioxidants might benefit high-risk patients by reducing the rate of ROS-induced mutations and delaying cancer initiation. However, dietary supplementation with antioxidants has generally proven ineffective or detrimental in clinical trials. High ROS levels limit cancer cell survival during certain windows of cancer initiation and progression. During these periods, dietary supplementation with antioxidants may promote cancer cell survival and cancer progression. This raises the possibility that rather than treating cancer patients with antioxidants, they should be treated with pro-oxidants that exacerbate oxidative stress or block metabolic adaptations that confer oxidative stress resistance.

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“…OMM fusion is regulated by mitofusins 1 and 2 (MFN1 and MFN2), which are required for the maintenance of a reticular mitochondrial network in cells. 7 Mitofusins function through homo-and heterotypic interactions, and their synthesis is regulated by transcriptional and post-transcriptional mechanisms ( Figure 2). 6 The transcriptional mitochondrial coactivators phosphatidylglycerol phospholipase C-1-alpha and beta (PGC-1-α and β), which regulate mitochondrial biogenesis and the expression of the respiratory complex machinery, have also been involved in the regulation of mitochondrial dynamics through control of gene expression.…”

Section: Mitochondrial Fusion and Fissionmentioning

confidence: 99%

“…Posttranslational modifications-P: phosphorylation; ub: ubiquitination; SUMO: sumoylation; PA: phosphatidic acid. 6,7,[10][11][12][13][14][15][16] cardiolipin, facilitates MFN-mediated fusion and ablation of mitoPLD induced mitochondrial fragmentation in vitro. 6 Inner membrane fusion is mediated by optic atrophy 1 (OPA1), another dynamin-like GTPase anchored to the IMM and mostly exposed to the intermembrane space (IMS).…”

Section: Mitochondrial Fusion and Fissionmentioning

confidence: 99%

Mitochondrial dynamics and cancer

et al. 2017

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Cancer is among the leading causes of death worldwide, and the number of new cases continues to rise. Despite recent advances in diagnosis and therapeutic strategies, millions of cancer-related deaths occur, indicating the need for better therapies and diagnostic strategies. Mitochondria and metabolic alterations have been recognized as important for cancer progression. However, a more precise understanding of how to manipulate mitochondria-related processes for cancer therapy remains to be established. Mitochondria are highly dynamic organelles which continually fuse and divide in response to diverse stimuli. Participation in the aforementioned processes requires a precise regulation at many levels that allows the cell to couple mitochondrial activity to nutrient availability, biosynthetic demands, proliferation rates, and external stimuli. The many functions of these organelles are intimately linked to their morphology. Recent evidence suggests an important link between mitochondrial morphology and disease, including neurodegenerative, inflammatory diseases and cancer. Here, we review recent advances in the understanding of mitochondrial dynamics with a special focus on its relationship to tumor progression.

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Regulators of mitochondrial dynamics in cancer

Cited by 205 publications

References 85 publications

The mitochondrial dynamics in cancer and immune-surveillance

The mitochondrial dynamics in cancer and immune-surveillance

Cancer, Oxidative Stress, and Metastasis

Mitochondrial dynamics and cancer

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