Regulator of G protein signaling 20 promotes proliferation and migration in bladder cancer via NF-κB signaling

Li, Gang; Wang, Meng; Lang, Ren; Li, Hanzong; Liu, Qinghua; Ouyang, Ying; He, Li-xin; Li, Fengyan

doi:10.1016/j.biopha.2019.109112

Cited by 15 publications

(14 citation statements)

References 30 publications

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“…This high expression of NEAT1 was positively correlated with advanced TNM stage (a system used to classify Tumor size, Node location, and Metastasis status) and poor survival of patients by promoting tumor cells proliferation and invasion, and inhibiting cell cycle arrest at the G0/G1 phase and apoptosis. It is proposed that NEAT1 could positively regulate the expression of the regulator of G protein signaling 20 (RGS20), an accelerator for the proliferation and migration of cancer cells [43,44], by interacting with miR-365 to suppress the repressive effects of miR-365 on the expression of RGS20 [45].…”

Section: Oral Squamous Cell Carcinomamentioning

confidence: 99%

NEAT1 as a competing endogenous RNA in tumorigenesis of various cancers: Role, mechanism and therapeutic potential

Yao

et al. 2021

Int. J. Biol. Sci.

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The nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) that is upregulated in a variety of human cancer types. Increasing evidence has shown that the elevation of NEAT1 in cancer cells promotes cell growth, migration, and invasion and inhibits cell apoptosis. It is also known that lncRNAs act as a competing endogenous RNA (ceRNA) by sponging microRNAs (miRNAs) to alter the expression levels of their target genes in the development of cancers. Therefore, it is important to understand the molecular mechanisms underlying this observation. In this review, specific emphasis was placed on NEAT1's role in tumor development. We also summarize and discuss the feedback roles of NEAT1/miRNA/target network in the progression of various cancers. As our understanding of the role of NEAT1 during tumorigenesis improves, its therapeutic potential as a biomarker and/or target for cancer also becomes clearer.

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Section: Oral Squamous Cell Carcinomamentioning

confidence: 99%

NEAT1 as a competing endogenous RNA in tumorigenesis of various cancers: Role, mechanism and therapeutic potential

Yao

et al. 2021

Int. J. Biol. Sci.

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“…Our study is the first research that identified the risk of RGS19 on BLCA by means of bioinformatic analysis in combination with experiment. In addition, we found a potential therapeutic drug, GSK1070916, for BLCA patients with high expression of RGS19 [31][32][33][34].…”

Section: Discussionmentioning

confidence: 93%

Genome-wide screening for the G-protein-coupled receptor (GPCR) pathway-related therapeutic gene RGS19 (regulator of G protein signaling 19) in bladder cancer

et al. 2021

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“…In triple-negative breast cancer, the high RGS20 expression is correlated with nodal metastasis and poor clinical outcome [ 19 ]. In bladder cancer, the high RGS20 expression was associated with unfavorable clinical outcomes [ 20 ]. Additionally, the RGS20 expression has been shown to be correlated with immune cell infiltration in renal cancer [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

RGS20 Promotes Tumor Progression through Modulating PI3K/AKT Signaling Activation in Penile Cancer

Shi

Tong

Han

et al. 2022

Journal of Oncology

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Regulator of G protein signaling 20 (RGS20) plays an important role in regulating neuronal G protein-coupled receptor signaling; however, its expression and oncogenic function in penile cancer (PC) remains unclear. Here, we observed high RGS20 expression in PC tissues compared to normal/adjacent penile tissues, which was closely associated with tumor stage, nodal status, and pelvic metastasis in our PC cohort. The cellular functional analysis of RGS20 revealed that manipulation of the RGS20 expression markedly affected cell viability, BrdU incorporation, soft agar clonogenesis, caspase-3 activity, and cell migration/invasion in PC cell models. Moreover, RGS20 could interact with PI3K p85α subunit and regulate PI3K/AKT signaling activation in PC cell lines. Knockdown of the PI3K p85α or p110α subunit attenuated cell viability, BrdU incorporation, soft agar clonogenesis, and cell migration/invasion in PC cell lines. In contrast, the overexpression of constitutively activated PI3K p110α mutant restored cell proliferation and cell migration/invasion caused by RGS20 depletion in PC cells. Consistent with the in vitro findings, RGS20 depletion attenuated PI3K/AKT signaling activation and suppressed tumor growth in a murine xenograft model. Importantly, the high RGS20 expression was associated with PI3K/AKT signaling activation and unfavorable progression-free/overall survival, highlighting the clinical relevance of RGS20/PI3K/AKT signaling in PC. In conclusion, the aberrant RGS20 expression may serve as a diagnostic and prognostic marker for PC. RGS20 may promote PC progression through modulating PI3K/AKT signaling activation, which may assist with the development of RGS20-targeting therapeutics in the future.

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Regulator of G protein signaling 20 promotes proliferation and migration in bladder cancer via NF-κB signaling

Cited by 15 publications

References 30 publications

NEAT1 as a competing endogenous RNA in tumorigenesis of various cancers: Role, mechanism and therapeutic potential

NEAT1 as a competing endogenous RNA in tumorigenesis of various cancers: Role, mechanism and therapeutic potential

Genome-wide screening for the G-protein-coupled receptor (GPCR) pathway-related therapeutic gene RGS19 (regulator of G protein signaling 19) in bladder cancer

RGS20 Promotes Tumor Progression through Modulating PI3K/AKT Signaling Activation in Penile Cancer

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