2015
DOI: 10.1016/j.ijcard.2014.10.088
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Regulator of G-protein signaling 2 (RGS2) in cardiology and oncology

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Cited by 20 publications
(3 citation statements)
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“…Rgs2 is highly expressed in neutrophils, while Rgs1 is not, and in contrast to Rgs1 , Rgs2 expression is not interferon inducible (16). Despite the similar expression pattern to Rgs1 , Rgs2 has not been linked to diseases of the immune system, but rather to cardiovascular and central nervous system dysfunction (91,92). However, analysis of mice lacking Rgs2 expression did reveal a role for RGS2 in T cell proliferation and anti-viral immune responses (93).…”
Section: G-protein Regulatory Proteinsmentioning
confidence: 99%
“…Rgs2 is highly expressed in neutrophils, while Rgs1 is not, and in contrast to Rgs1 , Rgs2 expression is not interferon inducible (16). Despite the similar expression pattern to Rgs1 , Rgs2 has not been linked to diseases of the immune system, but rather to cardiovascular and central nervous system dysfunction (91,92). However, analysis of mice lacking Rgs2 expression did reveal a role for RGS2 in T cell proliferation and anti-viral immune responses (93).…”
Section: G-protein Regulatory Proteinsmentioning
confidence: 99%
“…There have been many reports on the regulation of RGS2 in tumors, and the abnormal expression of RGS2 can be seen in a variety of tumors, such as colon cancer ( 46 ), ovarian cancer ( 47 ), and prostate cancer ( 48 ). RGS2 inhibits the growth of melanoma cells by inhibiting MAPK and AKT.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover oncosurgery represents a challenge for cardiologist [24] and preoperative cardiological assessment is the cornerstone of the modern oncosurgery as well as efficacious anesthesiological evaluation [24][25][26]. In the emerging scenario of concomitant problems and diseases [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41], physicians should be familiar with available drugs, environmental epidemiology and patient factors [24][25][26][27][28][29][30][31][32][33][34][35] as well as with new emerging findings with regard to use of cardiovascular drugs [27,28,[31][32][33][34][41][42][43]. Ruptured [44] mitral chordae tendineae are increasingly reported as an important cause of mitral regurgitation [45,46] being a common unrecognized contributo...…”
mentioning
confidence: 99%