Regulator of G-protein signaling 2 (RGS2) in cardiology and oncology

Patanè, Salvatore

doi:10.1016/j.ijcard.2014.10.088

Cited by 20 publications

(3 citation statements)

References 88 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rgs2 is highly expressed in neutrophils, while Rgs1 is not, and in contrast to Rgs1 , Rgs2 expression is not interferon inducible (16). Despite the similar expression pattern to Rgs1 , Rgs2 has not been linked to diseases of the immune system, but rather to cardiovascular and central nervous system dysfunction (91,92). However, analysis of mice lacking Rgs2 expression did reveal a role for RGS2 in T cell proliferation and anti-viral immune responses (93).…”

Section: G-protein Regulatory Proteinsmentioning

confidence: 99%

The impact of RGS and other G-protein regulatory proteins on Gαi-mediated signaling in immunity

Kehrl

2016

Biochemical Pharmacology

View full text Add to dashboard Cite

Leukocyte chemoattractant receptors are members of the G-protein coupled receptor (GPCR) family. Signaling downstream of these receptors directs the localization, positioning and homeostatic trafficking of leukocytes; as well as their recruitment to, and their retention at, inflammatory sites. Ligand induced changes in the molecular conformation of chemoattractant receptors results in the engagement of heterotrimeric G-proteins, which promotes α subunits to undergo GTP/GDP exchange. This results in the functionally release of βγ subunits from the heterotrimers, thereby activating downstream effector molecules, which initiate leukocyte polarization, gradient sensing, and directional migration. Pertussis toxin ADP ribosylates Gαi subunits and prevents chemoattractant receptors from triggering Gαi nucleotide exchange. The use of pertussis toxin revealed the essential importance of Gαi subunit nucleotide exchange for chemoattractant receptor signaling. More recent studies have identified a range of regulatory mechanisms that target these receptors and their associated heterotrimeric G-proteins, thereby helping to control the magnitude, kinetics, and duration of signaling. A failure in these regulatory pathways can lead to impaired receptor signaling and immunopathology. The analysis of mice with targeted deletions of Gαi isoforms as well as some of these G-protein regulatory proteins is providing insights into their roles in chemoattractant receptor signaling.

show abstract

Section: G-protein Regulatory Proteinsmentioning

confidence: 99%

The impact of RGS and other G-protein regulatory proteins on Gαi-mediated signaling in immunity

Kehrl

2016

Biochemical Pharmacology

View full text Add to dashboard Cite

show abstract

“…There have been many reports on the regulation of RGS2 in tumors, and the abnormal expression of RGS2 can be seen in a variety of tumors, such as colon cancer ( 46 ), ovarian cancer ( 47 ), and prostate cancer ( 48 ). RGS2 inhibits the growth of melanoma cells by inhibiting MAPK and AKT.…”

Section: Discussionmentioning

confidence: 99%

Elevated expression of LIF predicts a poor prognosis and promotes cell migration and invasion of clear cell renal cell carcinoma

Zhong

Liu²,

Li³

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

BackgroundRenal cell carcinoma (RCC) is the seventh most common cancer in humans, of which clear cell renal cell carcinoma (ccRCC) accounts for the majority. Recently, although there have been significant breakthroughs in the treatment of ccRCC, the prognosis of targeted therapy is still poor. Leukemia inhibitory factor (LIF) is a pleiotropic protein, which is overexpressed in many cancers and plays a carcinogenic role. In this study, we explored the expression and potential role of LIF in ccRCC.MethodsThe expression levels and prognostic effects of the LIF gene in ccRCC were detected using TCGA, GEO, ICGC, and ArrayExpress databases. The function of LIF in ccRCC was investigated using a series of cell function approaches. LIF-related genes were identified by weighted gene correlation network analysis (WGCNA). GO and KEGG analyses were performed subsequently. Cox univariate and LASSO analyses were used to develop risk signatures based on LIF-related genes, and the prognostic model was validated in the ICGC and E-MTAB-1980 databases. Then, a nomogram model was constructed for survival prediction and validation of ccRCC patients. To further explore the drug sensitivity between LIF-related genes, we also conducted a drug sensitivity analysis based on the GDSC database.ResultsThe mRNA and protein expression levels of LIF were significantly increased in ccRCC patients. In addition, a high expression of LIF has a poor prognostic effect in ccRCC patients. LIF knockdown can inhibit the migration and invasion of ccRCC cells. By using WGCNA, 97 LIF-related genes in ccRCC were identified. Next, a prognostic risk prediction model including eight LIF-related genes (TOB2, MEPCE, LIF, RGS2, RND3, KLF6, RRP12, and SOCS3) was developed and validated. Survival analysis and ROC curve analysis indicated that the eight LIF-related-gene predictive model had good performance in evaluating patients’ prognosis in different subgroups of ccRCC.ConclusionOur study revealed that LIF plays a carcinogenic role in ccRCC. In addition, we firstly integrated multiple LIF-related genes to set up a risk-predictive model. The model could accurately predict the prognosis of ccRCC, which offers clinical implications for risk stratification, drug screening, and therapeutic decision.

show abstract

“…Moreover oncosurgery represents a challenge for cardiologist [24] and preoperative cardiological assessment is the cornerstone of the modern oncosurgery as well as efficacious anesthesiological evaluation [24][25][26]. In the emerging scenario of concomitant problems and diseases [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41], physicians should be familiar with available drugs, environmental epidemiology and patient factors [24][25][26][27][28][29][30][31][32][33][34][35] as well as with new emerging findings with regard to use of cardiovascular drugs [27,28,[31][32][33][34][41][42][43]. Ruptured [44] mitral chordae tendineae are increasingly reported as an important cause of mitral regurgitation [45,46] being a common unrecognized contributo...…”

mentioning

confidence: 99%

Mitral valve prolapse caused from ruptured mitral chordae tendineae due to an infective endocarditis in cancer patient

Pugliatti

Zito

Adamo

et al. 2015

International Journal of Cardiology

Self Cite

View full text Add to dashboard Cite

Regulator of G-protein signaling 2 (RGS2) in cardiology and oncology

Cited by 20 publications

References 88 publications

The impact of RGS and other G-protein regulatory proteins on Gαi-mediated signaling in immunity

The impact of RGS and other G-protein regulatory proteins on Gαi-mediated signaling in immunity

Elevated expression of LIF predicts a poor prognosis and promotes cell migration and invasion of clear cell renal cell carcinoma

Mitral valve prolapse caused from ruptured mitral chordae tendineae due to an infective endocarditis in cancer patient

Contact Info

Product

Resources

About