Regulative effect of maternal serum fatty acid-binding protein 4 on insulin resistance and the development of gestational diabetes mellitus

Duan, Bide; Li, Yuan; Dong, Kun; Sun, Yi-Chih; Ma, Anlun; Yang, Xiangdong

doi:10.1016/j.plefa.2020.102213

“…In previous studies, researchers have observed elevated serum FABP4 levels in women diagnosed with GDM compared to healthy controls [ 67 , 79 , 149 , 150 , 151 , 152 ]. Fancis et al [ 65 ] evaluated the concentrations of a panel of 10 adipokines during pregnancy and their association with GDM risk.…”

Section: Biomoleculesmentioning

confidence: 99%

“…Inhibition of FABP4 by BMS309403 resulted in significant relief of GDM symptoms in the GDM mouse model, including improved glucose and insulin sensitivity. Researchers proposed that it may be an effective treatment for alleviating GDM [ 150 ].…”

Section: Biomoleculesmentioning

confidence: 99%

Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus

Ruszała

¹

,

Niebrzydowska

²

,

Pilszyk

³

et al. 2021

IJMS

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Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases in pregnant women. Its early diagnosis seems to have a significant impact on the developing fetus, the course of delivery, and the neonatal period. It may also affect the later stages of child development and subsequent complications in the mother. Therefore, the crux of the matter is to find a biopredictor capable of singling out women at risk of developing GDM as early as the very start of pregnancy. Apart from the well-known molecules with a proven and clear-cut role in the pathogenesis of GDM, e.g., adiponectin and leptin, a potential role of newer biomolecules is also emphasized. Less popular and less known factors with different mechanisms of action include: galectins, growth differentiation factor-15, chemerin, omentin-1, osteocalcin, resistin, visfatin, vaspin, irisin, apelin, fatty acid-binding protein 4 (FABP4), fibroblast growth factor 21, and lipocalin-2. The aim of this review is to present the potential and significance of these 13 less known biomolecules in the pathogenesis of GDM. It seems that high levels of FABP4, low levels of irisin, and high levels of under-carboxylated osteocalcin in the serum of pregnant women can be used as predictive markers in the diagnosis of GDM. Hopefully, future clinical trials will be able to determine which biomolecules have the most potential to predict GDM.

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“…Lower levels of HDL cholesterol could be related to the metabolic syndrome [39] or to the influence of BMI, since we also detected a negative correlation between HDL cholesterol and BMI. Proinflammatory cytokines and adipokines modulate pathways for insulin signaling, lipid metabolism, inflammatory response, and pathogenesis of GDM [11,27,[40][41][42][43]. For example, IL-6 directly inhibits insulin sensitivity and upregulates the release of hormones that contribute to insulin resistance via induction by insulin receptor's signal transduction in hepatocytes [44,45].…”

Section: Discussionmentioning

confidence: 99%

“…FABP4 is a regulator of lipid metabolism and facilitates the transport of fatty acids into cells. FABP4 is associated with obesity, insulin resistance, and T2D [9][10][11]. FABP4 levels may be significantly increased in GDM patients compared to non-GDM pregnant women [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

FABP4 and I-FABP Levels in Pregnant Women Are Associated with Body Mass Index but Not Gestational Diabetes

Vorobjova,

Tagoma,

Talja

et al. 2022

Journal of Diabetes Research

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Objectives. Gestational diabetes mellitus (GDM) is glucose intolerance detected initially during pregnancy. GDM poses an increased risk for the development of diabetes later in life. Fatty acid-binding protein 4 (FABP4) is a regulator of lipid metabolism and is associated with obesity, insulin resistance, and type 2 diabetes. Increased level of intestinal fatty acid-binding protein (I-FABP) may indicate impaired intestinal permeability, which may be an important contributor to the pathogenesis of type 1 diabetes and GDM. We aimed to compare FABP4 and I-FABP levels in pregnant women with GDM and in healthy pregnant controls, taking into consideration their prepregnancy body mass index (BMI), past exposures to enteroviruses (EV), and adipokine and cytokine levels, which have been shown to decrease insulin sensitivity. Material and Methods. Forty patients with GDM (median age 30.5) and 40 pregnant healthy controls (median age 31.1) were divided on the basis of their prepregnancy BMI into two groups: normal weight ( BMI < 25 , n = 20 ) and overweight ( BMI ≥ 25 , n = 20 ). FABP4 and I-FABP were measured from serum samples using commercial ELISA kits. Results. FABP4 and I-FABP levels did not differ between women with GDM and healthy pregnant controls ( p > 0.05 for both comparisons). However, both levels were associated with BMI ( p < 0.001 for both comparisons). Median I-FABP level was the highest in healthy controls with lower BMI (<25) ( p = 0.0009 ). FABP4 levels correlated with BMI and C-peptide values in both groups ( p < 0.001 ). Anti-EV antibody levels did not correlate with FABP4 or I-FABP levels. FABP4 and adiponectin levels were negatively correlated in controls ( r = − 0.61 , p = 0.0009 ), while I-FABP correlated positively with adiponectin ( r = 0.58 , p = 0.04 ) and resistin ( r = 0.67 , p = 0.04 ) levels in the GDM group. Conclusion. FABP4 and I-FABP levels were not dependent on the diagnosis of GDM, but rather on BMI. The correlation of I-FABP with adiponectin and resistin levels in women with GDM may suggests the importance of lipid metabolism in GDM-associated changes in intestinal permeability.

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“…Growing studies demonstrate that elevated circulating FABP4 levels correlate with an increased risk for obesity [ 24 ], type 2 diabetes [ 25 ], various cardiovascular diseases [ 26 ], and cancers [ 27 ] in a wide variety of populations. In pregnancy, increased serum FABP4 concentrations are observed in pregnant women with maternal obesity [ 28 , 29 ], GDM [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ], and PE [ 28 , 40 , 41 , 42 ]. However, its expression is detected in human placental trophoblast cells and is dispensable for maternal–fetal exchange and fetal growth [ 43 ].…”

Section: Introductionmentioning

confidence: 99%

Pathophysiological Insight into Fatty Acid-Binding Protein-4: Multifaced Roles in Reproduction, Pregnancy, and Offspring Health

Shi

¹

,

Wang

²

,

Wu

³

et al. 2023

IJMS

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Fatty acid-binding protein-4 (FABP4), commonly known as adipocyte-fatty acid-binding protein (A-FABP), is a pleiotropic adipokine that broadly affects immunity and metabolism. It has been increasingly recognized that FABP4 dysfunction is associated with various metabolic syndromes, including obesity, diabetes, cardiovascular diseases, and metabolic inflammation. However, its explicit roles within the context of women’s reproduction and pregnancy remain to be investigated. In this review, we collate recent studies probing the influence of FABP4 on female reproduction, pregnancy, and even fetal health. Elevated circulating FABP4 levels have been found to correlate with impaired reproductive function in women, such as polycystic ovary syndrome and endometriosis. Throughout pregnancy, FABP4 affects maternal–fetal interface homeostasis by affecting both glycolipid metabolism and immune tolerance, leading to adverse pregnancy outcomes, including miscarriage, gestational obesity, gestational diabetes, and preeclampsia. Moreover, maternal FABP4 levels exhibit a substantial linkage with the metabolic health of offspring. Herein, we discuss the emerging significance and potential application of FABP4 in reproduction and pregnancy health and delve into its underlying mechanism at molecular levels.

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Regulative effect of maternal serum fatty acid-binding protein 4 on insulin resistance and the development of gestational diabetes mellitus

Cited by 7 publications

References 38 publications

Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus

Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus

FABP4 and I-FABP Levels in Pregnant Women Are Associated with Body Mass Index but Not Gestational Diabetes

Pathophysiological Insight into Fatty Acid-Binding Protein-4: Multifaced Roles in Reproduction, Pregnancy, and Offspring Health

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