Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis
Soumyadeep Sarkar,
Cailin Deiter,
Jennifer E. Kyle
et al.
Abstract:Background
Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream signaling regulate β-cell death.
Methods
We performed lipidomics using three models of insulitis: human islets and EndoC-βH1 β cells treated with the pro-inflammatory cytokines interlukine-1β and interferon-γ, and islets from pre-diabe… Show more
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