Regulation of vitamin D metabolizing enzymes in murine renal and extrarenal tissues by dietary phosphate, FGF23, and 1,25(OH)2D3

Kägi, Larissa; Bettoni, Carla; Pastor-Arroyo, Eva M.; Schnitzbauer, Udo; Hernando, Nati; Wagner, Carsten A.

doi:10.1371/journal.pone.0195427

Cited by 33 publications

(32 citation statements)

References 53 publications

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“…However, it is difficult to discuss the function of FGF23 in cattle as it has not been identified as a useful method for measuring FGF23 in cattle. According to the studies in other species, FGF23 may have shown positive regulation with the decrease of iP in this study [ 9 , 10 ], but it is estimated that FGF23 may be less potent than the function of PTH, and other factors may be involved in the regulation of iP level, so there may be no significant difference in U-P.…”

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confidence: 62%

“…Also, the factors regulating iP in blood and its mechanisms are not yet clear. Research on fibroblast growth factor 23 (FGF23), which is known as one of the regulators of iP, has been actively conducted in experimental animals [ 9 , 10 ]. However, it is difficult to discuss the function of FGF23 in cattle as it has not been identified as a useful method for measuring FGF23 in cattle.…”

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confidence: 99%

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Changes in plasma pH and blood and urinary macromineral concentrations in experimentally induced hypocalcemic cows with Na<sub>2</sub>EDTA

Choi

Park

et al. 2020

The Journal of Veterinary Medical Science

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This study was performed to confirm the alterations of blood and urine parameters in artificially induced hypocalcemic cows. For a 2 × 2 cross-over design, four non-pregnant, non-lactating Holstein Friesian cows (623 ± 63 kg) were utilized. Cows in the treatment and control group were infused with ethylenediaminetetraacetic acid (Na 2 EDTA) solution and normal saline through an intravenous catheter for 3 hr, respectively. Laboratory analyses included complete blood cell count, plasma chemistry, blood gas analysis and urine chemistry. During the hypocalcemic period, abnormal signs were not observed clinically, hematologically nor biochemically either in groups. But, plasma calcium and magnesium concentrations continued to decrease throughout Na 2 EDTA infusion, and significant group differences ( P <0.05 or P <0.001) were detected until 5 hr after the initiation of infusion. Urinary excretions of these minerals were significantly reduced compared to the control group by 6 hr (Ca, P <0.05; Mg, P <0.001). Moreover, there is a significant group difference in the change in plasma pH at 1 hr after Na 2 EDTA infusion ( P <0.05) and maintained a decreased level until 6 hr. Consequently, the blood pH was diminished simultaneously with hypocalcemia and hypomagnesemia induction in cows infused with Na 2 EDTA. This phenomenon may be one of the mechanisms to recover normocalcemia including maximizing the effect of parathyroid hormone, however, further studies are needed to elucidate the mechanism to alter the blood pH in hypocalcemia.

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confidence: 62%

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confidence: 99%

Changes in plasma pH and blood and urinary macromineral concentrations in experimentally induced hypocalcemic cows with Na<sub>2</sub>EDTA

Choi

Park

et al. 2020

The Journal of Veterinary Medical Science

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“…Additionally, systemic inflammation, obesity, and parathyroid hormone levels have been associated with changes in circulating vitamin D levels. (12,(35)(36)(37)(38)(39)(40).…”

Section: Effect Of Storage Time and Seasonal Variation On Circulatingmentioning

confidence: 99%

Circulating Levels of Free 25(OH)D Increase at the Onset of Rheumatoid Arthritis

Anaparti

Meng

Mahadevappa

et al. 2019

Preprint

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Objective: Epidemiological studies suggest vitamin D deficiency as a potential risk factor for rheumatoid arthritis (RA) development, a chronic autoimmune disorder highly prevalent in indigenous North American (INA) population. We therefore profiled the circulating levels of 25-hydroxyvitaminD [25(OH)D], an active metabolite of vitamin D, in a cohort of at-risk first-degree relatives (FDR) of INA RA patients, a subset of whom subsequently developed RA (progressors). Methods: 2007 onward, serum samples from INA RA patients and FDR were collected at the time of a structured baseline visit and stored at -20°C. Anti-citrullinated protein antibodies (ACPA), 25(OH)D, hs-CRP, vitamin-D binding protein (VDBP) levels were determined using ELISA and rheumatoid factor (RF) seropositivity was determined by nephelometry. Results: We demonstrate that 25 (OH) D concentrations were lower in winter than summer (P=0.0538), and that serum 25(OH)D levels were higher in samples collected and stored after 2013 (P<0.0001). Analysis of samples obtained after 2013 demonstrated that 37.6% of study participants were 25(OH)D insufficient (<75nmol/L). Also, seropositive RA patients and FDR had lower 25(OH)D levels compared to ACPA-/FDR (P<0.05, P<0.01 respectively). Linear regression analysis showed 25(OH)D insufficiency was inversely associated with presence of RA autoantibodies. Longitudinal samples from 14 progressors demonstrated a consistent increase in 25(OH)D levels at the time they exhibited clinically detectable joint inflammation, without any significant change in VDBP levels. Conclusion:We demonstrate that 25(OH)D levels in serum increased at RA onset in progressors.The potential role that vitamin D metabolites and their downstream effects play in RA transition requires further investigation.

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“…However, whether it has a direct role in this is controversial, as 1,25(OH) 2 D itself is a potent inhibitor of CYP24A1 and separating the actions of FGF23 on 1,25(OH) 2 D and CYP24A1 is difficult. Other studies have found no effect of FGF23 on CYP24A1 gene expression [ 45 ]. Renal expression of VDR and CYP24A1 was significantly correlated in the sheep and dogs in this study, and this has also been reported in other studies [ 24 ].…”

Section: Discussionmentioning

confidence: 98%

Expression of Phosphatonin-Related Genes in Sheep, Dog and Horse Kidneys Using Quantitative Reverse Transcriptase PCR

Dittmer

Heathcott

Marshall

et al. 2020

Animals

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The aim of this preliminary study was to determine the relative expression of phosphatonin pathway-related genes in normal dog, sheep and horse kidneys and to explore the relationships between the different genes. Kidneys were collected post-mortem from 10 sheep, 10 horses and 8 dogs. RNA was extracted, followed by reverse transcriptase quantitative polymerase chain reaction for fibroblast growth factor receptor 1 IIIc (FGFR1IIIC), sodium-phosphate co-transporter (NPT) 1 (SLC17A1), NPT2a (SLC34A1), NPT2c (SLC34A3), parathyroid hormone 1 receptor (PTH1R), klotho (KL), vitamin D receptor (VDR), 1a-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24A1). NPT2a was highly expressed in the dog kidneys, compared with those of the horses and sheep. NPT1 had greatest expression in horses and sheep, although the three different NPTs all had relatively similar expression in sheep. There was little variability in FGFR1IIIc expression, particularly in the dogs and horses. FGFR1IIIc expression was negatively correlated with NPT genes (except NPT2a in sheep), while NPT genes were all positively correlated with each other. Unexpectedly, klotho was positively correlated with NPT genes in all three species. These results provide the basis for further research into this important regulatory system. In particular, species differences in phosphatonin gene expression should be considered when considering the pathogenesis of chronic kidney disease.

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Regulation of vitamin D metabolizing enzymes in murine renal and extrarenal tissues by dietary phosphate, FGF23, and 1,25(OH)2D3

Cited by 33 publications

References 53 publications

Changes in plasma pH and blood and urinary macromineral concentrations in experimentally induced hypocalcemic cows with Na<sub>2</sub>EDTA

Changes in plasma pH and blood and urinary macromineral concentrations in experimentally induced hypocalcemic cows with Na<sub>2</sub>EDTA

Circulating Levels of Free 25(OH)D Increase at the Onset of Rheumatoid Arthritis

Expression of Phosphatonin-Related Genes in Sheep, Dog and Horse Kidneys Using Quantitative Reverse Transcriptase PCR

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